期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 7, 页码 3457-3463出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo400090w
关键词
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资金
- Spanish Ministerio de Economia y Competitividad (MICINN)
- European Regional Development Fund [CTQ2011- 28417-C02-02]
- Spanish MEC
A novel approach to the synthesis of fully substituted pyrimidine derivatives armed with an oxy-functionalized acetate chain at the ring is described. The manifold uses amidines as the nitrogen source and activated skipped diynes as the electrophilic reactive partners in a coupled domino strategy. In the first domino reaction, two consecutive aza-Michael additions assemble the six-membered ring heterocycle, while in the second domino process, a [H]-shift and a [3,3]-sigmatropic rearrangement lead to the aromatization of the product.
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