☆ 4.7 Article

Pd-Catalyzed C-S Activation for [3+3] Annulation of 2-(Methylthio)benzofuran-3-carboxylates and 2-Hydroxyphenylboronic Acids: Synthesis of Coumestan Derivatives

JOURNAL OF ORGANIC CHEMISTRY (2013)

期刊

JOURNAL OF ORGANIC CHEMISTRY

卷 78, 期 14, 页码 7293-7297

出版社

AMER CHEMICAL SOC

DOI: 10.1021/jo400984h

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Chemistry, Organic

资金

New Century Excellent Talents in Chinese University [NCET-11-0613]
[NNSFC-21172031/21202017]

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摘要

Pd-catalytic C-S activation was successfully applied to initiate the cross-coupling of (2-methylthio-3-ester)benzofurans with 2-hydroxyphenylboronic acids and sequential intramolecular transesterification process under Liebeskind-Srogl conditions. Thus, a novel [3 + 3] annulation strategy for efficient synthesis of coumestan derivatives has been developed from readily available starting materials.

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