Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Psychiatry
Brian P. Brennan, Jiana Schnabel, Harrison G. Pope, James I. Hudson
Summary: The use of serotonergic antidepressants in hospitalized COVID-19 patients did not show a significant difference in outcomes compared to those not using antidepressants, based on the results of a study that aimed to replicate previous findings.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
George M. Anderson, Isabella Bruno-Pacella
Summary: This article assesses the bioeffect of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and compares them using neuroimaging and in vitro measurements. The study finds that these drugs typically result in a 70-90% reduction in platelet serotonin (5-HT) content. The bioeffect is similar among different types of SSRIs and SNRIs and is consistent with other assessment methods.
PSYCHOPHARMACOLOGY
(2023)
Review
Obstetrics & Gynecology
Yu-Shian Cheng, Cheuk-Kwan Sun, Pin-Yang Yeh, Ming-Kung Wu, Kuo-Chuan Hung, Hsien-Jane Chiu
Summary: The study found that serotonergic antidepressants are effective in treating sleep disturbances in perimenopausal and postmenopausal women, especially in those without major depressive disorder. The dropout rates were comparable between the antidepressant and placebo groups.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Kai Sun, Xianli Wang
Summary: This study investigated the use and trends of drugs for postpartum depression (PPD) in nine cities across China from 2016 to 2020. The results showed an increase in the number of PPD patients and total prescription amount during this five-year period. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) were the main drugs used for PPD treatment. The centralized drug-procurement policy in China has led to a significant reduction in drug costs, relieving the economic burden on patients.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yuying Huang, Hong Chen, Shao-Rui Chen, Hui-Lin Pan
Summary: Antidepressants, such as duloxetine and amitriptyline, are effective for treating chronic neuropathic pain by inhibiting norepinephrine and serotonin transporters and activating alpha 1-and alpha 2-adrenergic receptors in the spinal cord. This study provides important insights into the mechanism of action of antidepressants in alleviating neuropathic pain and can inform the development of improved treatment strategies.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yuying Huang, Hong Chen, Shao-Rui Chen, Hui -Lin Pan
Summary: Antidepressants are effective for treating chronic neuropathic pain by inhibiting glutamatergic input through activation of α1 and α2 adrenergic receptors.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Akhil Sood, Yong-Fang Kuo, Jordan Westra, Gulshan Sharma, Mukaila A. Raji
Summary: This study found that the combination of opioids with GABA and SSRI/SNRI is associated with a lower risk of acute respiratory events in COPD patients with co-occurring chronic pain and anxiety. The findings highlight the importance of multimodal management in this vulnerable population.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Peripheral Vascular Disease
Shehzad K. Niazi, Sobia H. Memon, Elizabeth R. Lesser, Emily Brennan, Nabeel Aslam
Summary: This study found that psychiatric patients using SSRIs/SNRIs had significantly higher nighttime systolic and diastolic blood pressure compared to those not using these medications, while there were no significant differences observed between patients with psychiatric diagnosis not on SSRIs/SNRIs. This suggests that the use of SSRIs/SNRIs may be associated with elevated blood pressure levels and further prospective studies are needed to evaluate the impact of these medications on blood pressure.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Pharmacology & Pharmacy
Soon H. Yang, Charles F. Seifert
Summary: The use of serotonergic antidepressants (SADs) during the perioperative period is associated with an increased risk of bleeding in patients undergoing orthopedic surgery. Patients on SADs had a higher percentage of requiring transfusion and a longer hospital stay compared to those not on SADs.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Toxicology
Geoffrey K. Isbister, Robert Polanski, Joyce M. Cooper, Michael Keegan, Katherine Z. Isoardi
Summary: This study investigated the frequency and severity of clinical effects following duloxetine overdose. The results showed that duloxetine overdose most commonly caused sympathomimetic effects and serotonin toxicity, but did not result in coma, arrhythmias, or intensive care unit admission.
CLINICAL TOXICOLOGY
(2022)
Article
Toxicology
Elias Bekka, Florian Eyer
Summary: This study investigated the association between venlafaxine exposure and hypoglycemia in non-diabetic patients with antidepressant overdose. Results showed that 34.1% of venlafaxine intoxications resulted in hypoglycemia. Venlafaxine exposure was significantly associated with hypoglycemia. Hypoglycemia was associated with seizures and prolonged hospital stay.
CLINICAL TOXICOLOGY
(2022)
Review
Behavioral Sciences
Paul J. Fitzgerald
Summary: Major depressive disorder (MDD) continues to be a significant public health issue globally. While drugs that boost monoamines have shown antidepressant properties, there is also evidence that drugs reducing monoaminergic transmission may have antidepressant-like behavioral effects. It remains to be determined whether these drugs are effective antidepressants in human subjects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Suresh Paudel, Eunae Kim, Anlin Zhu, Srijan Acharya, Xiao Min, Seung Hoon Cheon, Kyeong-Man Kim
Summary: This study identified the diverse effects of synthetic 4-benzylpiperidine carboxamides on serotonin, norepinephrine, and dopamine reuptake, as well as the critical structural features contributing to the selectivity of these molecules for each of the monoamine transporters. Additionally, the study found that specific residues on the compounds bound to the transporters and highlighted the functional role of a dopamine reuptake inhibitor in regulating dopamine D-2 receptor function.
BIOMOLECULES & THERAPEUTICS
(2021)
