4.7 Article

Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3H)-ones

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 78, 期 7, 页码 3323-3328

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AMER CHEMICAL SOC
DOI: 10.1021/jo4001959

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资金

  1. National Natural Science Foundation of China [51073150, 21172211]
  2. Department of Science and Technology of Jilin Province [20111802]
  3. Chinese Academy of Sciences

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A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6 pi-azaelectrocyclization. The intra-molecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.

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