Review
Biochemistry & Molecular Biology
Amy E. Medlock, Harry A. Dailey
Summary: This review summarizes new studies on the regulation of heme synthesis, including regulation of porphyrin synthesis via carbon flux and post-translational modifications (PTMs) that regulate individual enzymes. The role of immunometabolite itaconate and its connection to heme synthesis and the anemia of chronic disease are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Xu-Kun Wang, Yue-Mei Jia, Yi-Xian Li, Chu-Yi Yu
Summary: A new antibiotic called pseudouridimycin with a unique mode of action against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains, was synthesized using an efficient and practical convergent strategy.
Review
Chemistry, Organic
Ankita Thakur, Manisha, Inder Kumar, Upendra Sharma
Summary: In the last three decades, the resurgence and astonishing evolution of visible light-mediated unreactive C-H bond functionalization has led to a sustainable and greener approach for introducing various moieties into imperative organic frameworks without the need for substrate preactivation.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Michael Gross
Summary: The concept of citizen science has been widely applied in the fields of ecology, conservation and archaeology, with the fieldwork of volunteer helpers playing a crucial role in the implementation of these major projects. Today, with advancements in technology, people can even contribute to citizen science research from home through simple means.
Article
Chemistry, Multidisciplinary
Jiujian Ji, Jiajun Chen, Sixun Qin, Wanye Li, Jun Zhao, Guozhao Li, Hao Song, Xiao-Yu Liu, Yong Qin
Summary: This article reports the first total synthesis of vilmoraconitine using efficient ring-forming reactions. Key steps include an oxidative dearomatization-induced Diels-Alder cycloaddition, a hydrodealkenylative fragmentation/Mannich sequence, and an intramolecular Diels-Alder cycloaddition.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Qiaoqiao Ao, Hai-Jun Zhang, Jinbin Zheng, Xiaoming Chen, Hongbin Zhai
Summary: The first asymmetric total synthesis of (+)-Mannolide C has been achieved through key transformations such as lipase-mediated resolution, Ru-complex-catalyzed double ring-closing metathesis (RCM) reactions, Ni-II-catalyzed diastereoselective Michael addition, and Mn-III-catalyzed allylic oxidation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jyoti Shukla, Manoj Kumar Gangwar, Dipankar Koley
Summary: The total synthesis of (-)-delta-lycorane is achieved through organocatalytic Mannich reaction and diastereoselective conjugate addition. Various reactions including Bischler-Napieralski reaction and ring closing metathesis are utilized.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Miriam Picciche, Alexandre Pinto, Rosa Griera, Joan Bosch, Mercedes Amat
Summary: The enantioselective synthesis of (-)-cylindricine H from (R)-phenylglycinol-derived tricyclic lactam 1 is reported. Key steps include the stereoselective generation of the quaternary C-10 stereocenter, the stereoselective introduction of the C-4 acetoxy and C-2 butyl substituents taking advantage of the lactam carbonyl functionality, and the assembly of the pyrrolidine ring with the required functionalized one-carbon chain at C-13 by intramolecular opening of an epoxide.
Article
Chemistry, Multidisciplinary
Si-Hua Hou, Adriana Y. Prichina, Guangbin Dong
Summary: The development of a deconstructive strategy for the first asymmetric synthesis of (-)-thebainone A was described, utilizing an enantioselective C-C bond activation and a C-O bond cleavage reaction. The newly optimized conditions show broad substrate scope and excellent enantioselectivity (up to 99.5:0.5 er). The synthesis of (-)-thebainone A was completed by taking advantage of boron-mediated ether bond cleavage through two complementary routes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Yuya Komatani, Kyoka Momosaki, Akira Katsuyama, Kazuki Yamamoto, Rintaro Kaguchi, Satoshi Ichikawa
Summary: A solid-phase total synthesis method for the C2-symmetric cyclic decadepsipeptide natural product sandramycin (1) and its analogues is described. The synthesis involved on-resin ester formation and [5+5] peptide coupling to prepare a range of desymmetrized analogues. A suitable amino acid residue that does not interfere with the biological activity of 1 was identified, and probe molecules and dimeric analogues were prepared based on the structure-activity relationship study.
Article
Chemistry, Multidisciplinary
Vasil H. Vasilev, Lukas Spessert, Kuan Yu, Thomas J. Maimone
Summary: The large family of daphnane diterpene orthoesters (DDOs) represents a remarkable class of natural products both in terms of structure and function. They are potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer. However, the synthesis of DDO natural products remains rare.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Zhi Zhang, Liansuo Zu
Summary: The study successfully synthesized a steroid-sterigmatocystin heterodimer using a concise method, including cascade dialdehyde cyclization, phenol-assisted reductive alkylation, and SNAr reaction. The research also explored a glycosylation-inspired method to provide the acetal linkage with ergosterol peroxide.
Article
Chemistry, Organic
Jason An, Richard K. Jackson, Joseph P. Tuccinardi, John L. Wood
Summary: This paper presents an efficient, scalable, and concise approach for the synthesis of an advanced pyrroloiminoquinone synthetic intermediate (6b) using Larock indole synthesis. The synthetic utility of this intermediate is demonstrated by its ready conversion to makaluvamines A (1) and K (4).
Article
Chemistry, Organic
Chengxiang Shang, Chuanfang Zhao, Pengpeng Nie, Jun Liu, Yuguo Du
Summary: A short and scalable approach was developed for the total synthesis of schaftoside from readily available (+/-)-naringenin, highlighting a double Lewis acid promoted O -> C rearrangement, oxidative dehydrogenation to construct flavone ring, and an easy operational process to produce the target product in multigram-scale.
Article
Chemistry, Organic
Shota Iiyama, Keisuke Fukaya, Yu Yamaguchi, Ami Watanabe, Hiroaki Yamamoto, Shota Mochizuki, Ryosuke Saio, Takashi Noguchi, Takeshi Oishi, Takaaki Sato, Noritaka Chida
Summary: The total synthesis of paclitaxel is achieved through a double Rubottom oxidation of the bis(silyl enol ether) derived from a tricarbocyclic diketone, efficiently installing a bridgehead olefin and C-5/C-13 hydroxy groups in one step. Additionally, a novel Ag-promoted oxetane formation method is used to smoothly construct the tetracyclic framework of paclitaxel.