Article
Chemistry, Organic
Ping Wu, Liandi Wang, Kaikai Wu, Zhengkun Yu
Summary: This study addresses the challenge of the direct synthesis of triazole 2-oxides in the field of N-heterocyclic chemistry. By utilizing a novel copper-catalyzed nitrosylation/annulation cascade of enaminones and using noncorrosive tert-butyl nitrite, the synthesis of 1H-1,2,3-triazole 2-oxides with wide substrate scopes and good tolerance to various functional groups is achieved.
Article
Chemistry, Organic
Jun Yang, Lina Yang, Jing Gu, Li Shuai, Hui Wang, Qin Ouyang, Yu-Long Li, Haibin Liu, Liang Gong
Summary: In this study, a nickel-catalyzed reductive deaminative arylalkylation of tethered alkenes with pyridinium salts as C(sp(3)) electrophiles is described. This two-component dicarbofunctionalization reaction enables the efficient synthesis of various benzenefused cyclic compounds bearing all-carbon quaternary centers. The method proceeds under mild conditions and tolerates a wide range of functional groups and heterocycles, making it applicable for late-stage functionalization of complex molecules.
Article
Chemistry, Multidisciplinary
Matteo Faltracco, Koen N. A. van de Vrande, Martijn Dijkstra, Jordy M. Saya, Trevor A. Hamlin, Eelco Ruijter
Summary: A palladium-catalyzed intermolecular cascade (4+3) cyclocondensation reaction using salicylaldehydes and vinylcyclopropanes as substrates is reported, with the utilization of a phosphonate group on the cyclopropane as an acceptor moiety. This reaction facilitated the formation of substituted benzoxepins through subsequent O-allylation, with good yield and reasonable enantioselectivity achieved using a novel chiral ligand.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chao Liu, Xiangwen Tan, Lingzhi Zhan, Yaru Jing, Wanqing Wu, Zhuofeng Ke, Huanfeng Jiang
Summary: A novel and efficient strategy for synthesizing fused benzo-aza-oxa-[5-6-5] tetracycles with high yields and diastereoselectivities has been demonstrated. This strategy involves the synthesis of functionally divergent anilines and 3-butenoic acid with five chemical bonds constructed. Control experiments and DFT calculations were performed to support the proposed mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yujie Dong, Jun Liu, Xing Gao, Ting Pan, Biming Mao, Songcheng Yu, Yongjun Wu, Cheng Zhang, Hongchao Guo
Summary: A palladium-catalyzed cascade cyclization was developed for the synthesis of biologically active tetracyclic dihydrocyclopentaindenofuranone derivatives. The reaction exhibited moderate to high yields and excellent diastereoselectivities, with the allene moiety fully fused into the cyclopentene ring.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Organic
Zongli Xiong, Jingxiang Duan, Xiaoyi Li, Xin Wang, Yesu Addepalli, Mengxue Lu, Weijun Yao, Ling He, Zhen Wang
Summary: The palladium-catalyzed chemo- and stereoselective [2 + 2 + 2] annulation reaction of 2-(2-enynyl)pyridines with arynes has been developed. A wide range of (E)- or (E/Z)-isomers of 2-(2-enynyl)pyridines and arynes was tolerated, providing a spectrum of (E)-phenanthrenylated 2-alkenylpyridines in good yield, together with the generation of a chiral axis between an alkene and a phenanthrene ring.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yi Liu, Juan Cao, Mei Zhang, Zenghui Zhang, Chengcai Xia, Guili Guo, Fugang Wang
Summary: We have developed a route for the cycloaddition reaction of alkenes and tert-butyl nitrite to synthesize Delta 2-isoxazolines. This method allows the formation of multiple chemical bonds without the use of a catalyst. It features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of isoxazolines.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xi Sun, Xu Dong, Yi Yang, Jiangchen Fu, Yan Wang, Zirui Li, Yuying Liu, Hui Liu
Summary: A novel and convenient palladium-catalyzed cascade reaction has been developed for the synthesis of potentially bioactive hexahydroindole derivatives, demonstrating high functional group tolerance and stereoselectivity. Mechanistic studies suggest the involvement of an alkyl radical pathway in this reaction.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Ryunosuke Ito, Yoshifumi Okura, Masahisa Nakada
Summary: A Pd-catalyzed intramolecular cyclization-thiocarbonylation cascade using thioesters is developed, yielding chromane, coumaran, indoline, and oxindole derivatives with a chiral quaternary carbon atom at the benzylic position in high to excellent yields. Compared to the previously reported method using TIPSSPh, the use of thioesters in this cascade reaction provides similar or higher yields, depending on the substrate, with significantly reduced reaction time.
Article
Biochemistry & Molecular Biology
Ida Ziccarelli, Lucia Veltri, Tommaso Prestia, Roberta Amuso, Maria A. Chiacchio, Raffaella Mancuso, Bartolo Gabriele
Summary: Unreported 2-(4-acylfuran-2-yl)acetamides were selectively synthesized in fair to good yields (54-81%) over 19 examples through a mild catalytic process involving Csp-H activation, 5-exo-dig O-cyclization, and aromative isomerization.
Article
Chemistry, Organic
Rana Chatterjee, Mohanreddy Pothireddy, Rambabu Dandela
Summary: An efficient copper-catalyzed intermolecular decarboxylative cascade cyclization was developed using readily accessible starting materials and less-expensive reagents. A one-pot reaction of an aryl aldehyde, an aniline, and acrylic acid allows for the direct synthesis of 2-substituted quinolines through sequential C-N and C-C bond formation. The three-component, one-pot, domino strategy demonstrates promising chemo- and regioselectivity, high functional-group tolerance, excellent yields, a radical reaction pathway, and aerobic reaction conditions.
Article
Chemistry, Multidisciplinary
Yifan Wang, Yuanyuan Ping, Wangqing Kong
Summary: A cooperative Pd/Cu-catalyzed three-component cross-coupling reaction of alkynes, B 2 Pin 2 and alkenetethered aryl halides is reported. This reaction proceeds under mild conditions and shows broad substrate scope, providing a variety of heterocycles containing tetrasubstituted alkenylboronate moieties in synthetically useful yields with excellent chemoselectivity and regioselectivity. An enantioselective cascade cyclization/cross-coupling process has also been developed for the synthesis of enantiomerically enriched oxindole bearing a tetrasubstituted alkenylboronate moiety.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Organic
Subhendu Ghosh, Tamanna Khandelia, Pritishree Panigrahi, Raju Mandal, Bhisma K. Patel
Summary: A site-selective non-directed C3-maleimidation of quinoxaline is achieved through Mn-(I)-catalyzed reaction. The electrophilic C3-metalation is preferred over the o-directed strategy, leading to diversely substituted quinoxaline-appended succinimides. The products undergo PIFA-promoted C-(sp(2))-C-(sp(3)) spirocyclization via pi-electrons drifting from aryls and Selectfluor-mediated dehydrogenation of succinimide at room temperature.
Article
Chemistry, Physical
Dan Wen, Xing Ge, Ren-Guan Miao, Xinxin Qi, Xiao-Feng Wu
Summary: A palladium-catalyzed carbonylative synthesis of carboxamide substituted 2-pynones from methyl enynoates and nitroarenes has been developed. A wide range of carboxamide substituted 2-pynones were obtained in moderate to high yields with quite high functional group compatibility using nitroarenes as the nitrogen sources and Mo(CO)6 as both CO surrogate and reductant. Late-stage modifications of natural molecules were also achieved.
JOURNAL OF CATALYSIS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Hirokazu Tsukamoto, Kazuya Ito, Tatsuhiko Ueno, Mitsugu Shiraishi, Yoshinori Kondo, Takayuki Doi
Summary: Palladium(0)/monophosphine complexes catalyze anti-selective alkylative, arylative, and alkynylative cyclizations of alkynyl electrophiles with organometallic reagents. Triphenylphosphine (PPh3)-ligated palladium(0) catalyzes the cyclization of 5-alkynals to afford 2-cyclohexen-1-ol and 2-alkylidene-cyclopentanol derivatives. Palladium/tricyclohexylphosphine (PCy3) catalyst switches the regioselectivity in the cyclization of conjugated diyne-aldehydes.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Yan Jia, Yiying Wang, Yongli Zhang, Jiayue Wang, Yanxi Pei, Zhiqing Wang, Peng Li, Keli Han
Summary: The study developed novel fluorescent probes CBLP and CSEP for effective monitoring of cystathionine lyase activity, providing a new approach for the analysis of cystathionine lyase in biological processes.
ANALYTICAL CHEMISTRY
(2022)
Article
Optics
Siping Liu, Bin Yang, Junsheng Chen, Daoyuan Zheng, Zhe Tang, Weiqiao Deng, Keli Han
Summary: This study presents the colloidal synthesis of lead-free vacancy-ordered Cs2HfCl6 perovskite NCs using hafnium acetylacetonate as metal precursors and proposes a passivation strategy for sub-bandgap trap states by doping Sb3+ ions. Additionally, the introduction of lanthanide ions enables tunable multicolor emissions in Cs2HfCl6 NCs, providing effective strategies for tuning the optical properties of lead-free vacancy-ordered perovskite NCs.
LASER & PHOTONICS REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Weihong Song, Qinglian Du, Xiancheng Li, Shuizhong Wang, Guoyong Song
Summary: Catechyl lignin (C-lignin) is a promising biopolymer for the synthesis of bioactive molecules. Diversified transformations of propenylcatechol, a depolymerized product of C-lignin, were reported, resulting in the preparation of functional molecular skeletons for pharmaceuticals and bioactive molecules. The study demonstrated the low carbon footprint and high-quality production of bioactive molecules from C-lignin.
Article
Biophysics
Danyang Chen, Xiaojun Liu, Yuehua Qi, Xiangbo Ma, Yong Wang, Hongzan Song, Youliang Zhao, Wenjuan Li, Jianglei Qin
Summary: In this study, a novel hemostatic hydrogel with excellent biocompatibility, tissue adhesion, hemostatic performance, and intrinsic antibacterial activity was prepared. It showed the ability to repair cracks when broken and promoted wound repair and tissue regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Multidisciplinary Sciences
Zhicheng Liu, Dongxu Lin, Yi Zhou, Linmeng Zhang, Chen Yang, Bin Guo, Feng Xia, Yan Li, Danyang Chen, Cun Wang, Zhong Chen, Chao Leng, Zhenyu Xiao
Summary: In this study, large-scale genomic profiles from ccRCC cohorts were analyzed to identify synthetic lethality pairs and potential medical targets. BRD4 and PRKDC were identified as novel targets for patients with BAP1 mutations, and two drugs, BI-2536 and PI-103, were found to have therapeutic potential for BAP1 mutant tumors. Overall, this study provides insight into ccRCC mutation patterns and offers new opportunities for personalized cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Acoustics
Dandan Chen, Juan Xia, Shurui Xie, Yafeng He, Xiaojing Ma
Summary: This case report highlights the successful diagnosis and treatment of a rare case of unruptured right SOVA using transthoracic echocardiography, contrastive echocardiography, and transesophageal echocardiography.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Chemistry, Physical
Xin Mao, Zhongyi Wang, Fen Zhang, Hong Yin, Xin Xu, Junsheng Chen, Zhen Chen, Junhua Luo, Keli Han, Ruiling Zhang
Summary: In this paper, the synthesis and photophysical properties of high-quality Sb3+-doped 0D Rb2ScCl5(H2O) perovskite single crystals are reported. It is found that the emission quantum yield can be dramatically enhanced from less than 1% to about 53% via Sb3+ doping. Spectroscopic characterizations indicate that the photoluminescence enhancement is a result of the efficient energy transfer from Sb3+ to the emissive self-trapped excitons. Additionally, 0.2%Sb3+:Rb2ScCl5(H2O) single crystals exhibit potential application in direct X-ray detection with a high sensitivity of 58.5 mu C Gy-1 cm-2.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Polymer Science
Yihan Wang, Shihao Su, Guoyong Song
Summary: In this study, lignins were isolated from different parts of the castor plant and their structural features were investigated. The results showed that the endocarp and epicarp lignins had higher yields and selectivity of aromatic monomers. This work highlights the differences in lignins from various parts of the castor plant and provides a solid theory for the high-value utilization of the whole plant.
Article
Engineering, Multidisciplinary
Qingru Shen, Shuizhong Wang, Guoyong Song
Summary: In this study, a unique crystallite structure of C-lignin nanoparticles was discovered, and compositing with PVA resulted in materials with improved mechanical properties and various desirable characteristics. This work introduces a novel sustainable building block for strong polymeric materials and discovers a new route for the valorization of waste biomass.
COMPOSITES PART B-ENGINEERING
(2023)
Editorial Material
Green & Sustainable Science & Technology
Shuizhong Wang, Guoyong Song
Summary: Aromatic compounds are widely used in daily life, but their production relies heavily on fossil resources. A new strategy has been developed to synthesize benzenoid aromatics from bioderived feedstock, offering a more sustainable approach to aromatic production.
NATURE SUSTAINABILITY
(2023)
Article
Chemistry, Multidisciplinary
Jia Shi, Shuizhong Wang, Helong Li, Guoyong Song
Summary: Lignin, a renewable aromatic resource, can be selectively fragmented into hydroxycinnamic derivatives over a ZnMoO4/MCM-41 catalyst, which can then be converted into aromatic diesters. These diesters, when copolymerized with holocellulose-derived compounds, result in aliphatic-aromatic polyesters with controllable properties. The copolyesters can be fully converted into monomers, demonstrating excellent recyclability. This study provides a novel route for the synthesis of functional polymers from sustainable biomass.
Article
Chemistry, Physical
Xin Mao, Zhongyi Wang, Fen Zhang, Hong Yin, Xin Xu, Junsheng Chen, Zhen Chen, Junhua Luo, Keli Han, Ruiling Zhang
Summary: In this study, high-quality Sb3+-doped 0D Rb2ScCl5(H2O) perovskite single crystals were synthesized and their photophysical properties were investigated. The introduction of Sb3+ dramatically enhanced the emission quantum yield from less than 1% to about 53%. Spectroscopic characterizations revealed that the enhancement was attributed to efficient energy transfer from Sb3+ to the emissive self-trapped excitons (STE). Moreover, 0.2%Sb3+:Rb2ScCl5(H2O) single crystals showed potential applications in direct X-ray detection with a high sensitivity of 58.5 mu C Gy(-1) cm(-2).
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Review
Materials Science, Multidisciplinary
Pengfei Cheng, Keli Han, Junsheng Chen
Summary: Metal halide perovskites, with their excellent photophysical properties, have attracted extensive attention in the field of photocatalysis. However, the toxicity and instability issues of conventional lead-based perovskites limit their application prospects. The rapid development of lead-free halide perovskites (LFHPs) provides new opportunities for photocatalysis. This Review summarizes the recent progresses of LFHPs for photocatalytic applications and discusses strategies to improve their performance and stability.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Shihao Su, Fan-shu Cao, Shuizhong Wang, Qingru Shen, Gen Luo, Qiang Lu, Guoyong Song
Summary: This study demonstrates for the first time that tris(pentafluorophenyl)borane can efficiently catalyze the depolymerization of C-lignins containing benzodioxane structures, resulting in high yields of catechol derivatives at room temperature and ambient pressure. This method provides an economic and environmentally-friendly approach for the production of catechols from biomass waste.
Article
Food Science & Technology
Shijie Shi, Gaoyu Zhang, Lina Li, Dandan Chen, Juan Liu, Cougui Cao, Yang Jiang
Summary: Nitrogen fertilizer application has a direct impact on the eating quality of rice, leading to a decrease in the overall quality. This is attributed to the increased protein content in the outer layer of rice and the changes in starch structure, which result in reduced gelatinization properties of starch and overall rice quality.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
