期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 6, 页码 2718-2728出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo202508n
关键词
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资金
- DFG [RI 1063/13-1]
- Center for Functional Nanostructures at KIT
A method for the solution-phase synthesis of branched oligonucleotides with tetrahedral or pseudo-octahedral geometry is described that involves the coupling of 3'-H-phosphonates of protected dinucleoside phosphates and organic core molecules. The dimer building blocks are produced by a synthesis that requires no chromatographic purification and that produces the diner H-phosphonates in up to 44% yield in less than three days of laboratory work. A total of seven different branched hybrids were prepared, including a new hybrid of the sequence (CG)(4)TBA, where TBA stands for tetrakis(p-hydroxybiphenyl)adamantane that assembles into a material from micromolar aqueous solution upon addition of MgCl2.
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