期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 9, 页码 4198-4208出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo300160e
关键词
-
资金
- NSF [CHE-0741968]
- NIH [TW006634, NS053398, DA007315]
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curacao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
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