期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 3, 页码 1251-1257出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo202566h
关键词
-
资金
- National Natural Science Foundation of China [21072028, 20832008]
- National Basic Research Program of China [2012CB21600]
Trifluoromethylated acetylenes and arenes are widely applicable in the synthesis of pharmaceuticals and agrochemicals. In 2010, our group has reported the copper-mediated oxidative trifluomethylation of terminal alkynes and aryl boronic acids. This method allows a wide range of functional group tolerant trifluoromethylated acetylenes and arenes to be easily prepared. After the preliminary mechanistic studies of the oxidative trifluoromethylation of terminal alkyne, an efficient copper-catalyzed oxidative trifluoromethylation of terminal alkynes and aryl boronic acids has been developed. The catalytic protocol is successfully achieved by adding both the substrate and a portion of CF3TMS slowly using a syringe pump to the reaction mixture.
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