Article
Chemistry, Multidisciplinary
Feng Xu, Haoying Ge, Ning Xu, Cheng Yang, Qichao Yao, Saran Long, Wen Sun, Jiangli Fan, Xinsheng Xu, Xiaojun Peng
Summary: In this study, a quartet photosensitizer Cy-DENT with high singlet oxygen quantum yield was reported, achieved through a radical enhanced inter-system crossing process. By introducing a TEMPO radical, over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN could be achieved under near infrared light irradiation. The electron-donating ability of the terminal substituent group can effectively control the production of singlet oxygen.
SCIENCE CHINA-CHEMISTRY
(2021)
Review
Physics, Multidisciplinary
Irving D. Rettig, Theresa M. McCormick
Summary: In theory, oxygen is an ideal chemical reagent, but its reactivity is limited in practice. More reactive forms of oxygen can be achieved through photochemical methods and used in various applications..HandlerFunc
ADVANCES IN PHYSICS-X
(2021)
Article
Chemistry, Inorganic & Nuclear
Chaochao Fan, Yue Wang, Jie Zhao, Yanxia Zhao, Dong Yang, Boyang Li, Le Yu, Xiao-Juan Yang, Biao Wu
Summary: In this study, two photoactive ligands were designed and used to construct sulfate complexes. These complexes can undergo oxygenation reactions under light, storing singlet oxygen, and partially recover the original structures after heating.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Paulina Skupin-Mrugalska, Tomasz Koczorowski, Wojciech Szczolko, Jolanta Dlugaszewska, Anna Teubert, Hanna Piotrowska-Kempisty, Tomasz Goslinski, Lukasz Sobotta
Summary: The newly synthesized cationic water-soluble magnesium(II) and zinc(II) sulfanyl porphyrazines showed hydrophilic properties and poor binding to liposomes, resulting in lower logPo/w values for octaiodide salts compared to their neutral precursors. Moreover, they exhibited moderate singlet oxygen generation yields and higher susceptibility to decomposition after light exposure.
Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Daniel Ziental, Dariusz T. Mlynarczyk, Emil Kolasinski, Emre Guzel, Jolanta Dlugaszewska, Lukasz Popenda, Stefan Jurga, Tomasz Goslinski, Lukasz Sobotta
Summary: Phthalocyanines have been widely used as photosensitizers in photodynamic antimicrobial therapy (PACT) due to their superior properties. In this study, zinc(II) and palladium(II) phthalocyanine complexes were synthesized and characterized. The palladium(II) complex showed the highest bactericidal activity against antibiotic-resistant microorganisms.
Article
Spectroscopy
Xiaorong Wang, Hui Lv, Yingkai Sun, Guoping Zu, Xiaozhen Zhang, Yufang Song, Fengyang Zhao, Jingang Wang
Summary: Research on porphyrin-based photosensitizer system is of great theoretical and practical significance in photodynamic therapy (PDT) for cancer treatment. In this article, a series of porphyrin derivatives were designed and synthesized, leading to the construction of a push-pull porphyrin photosensitizer with two symmetrical ethanethioate groups. Through characterization and theoretical analysis, the relationship between porphyrin structure and properties was revealed. The synthesized porphyrin compounds demonstrated high singlet oxygen generation and low dark toxicity under long-wavelength light.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Ming Zhao, Cheng Liu, Zhihao Shan, Changqing Ji, Xiaozhong Lu, Guanglei Lv
Summary: In this study, a dual-core metal photosensitizer was synthesized and doped into polymer fibrous films to generate singlet oxygen (O-1(2)). The Re(I)-based component directly converted O-3(2) to O-1(2), while the Gd(III)-based component facilitated the transformation through synergistic effect. The photophysical parameters of the photosensitizer and its fibrous films were recorded and compared. It was found that the lifetime and photostability of the photosensitizer were improved after being doped into the fibrous films, leading to enhanced O-1(2) generation. Comparison with reference films confirmed the positive impact of synergistic effect on O-1(2) production efficiency.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qing Gao, Katarzyna Grzyb, Luke F. Gamon, Peter R. Ogilby, Tomasz Pedzinski, Michael J. Davies
Summary: Disulfide bonds are critical for protein structure and function, and their modification can lead to loss of structure and function. This study investigates the oxidation of disulfide bonds by singlet oxygen, showing selective oxidation and variation in reaction rates and product formation. These findings suggest that certain disulfides, including those in proteins, may undergo detrimental modifications that affect protein structure and function.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Environmental
Xinlong Pang, Haoran Zhao, Yuanxiong Cao, Jiaqi Wang, Zhiwei Hu, Wilhelm T. S. Huck, Shaohua Ma
Summary: Researchers have developed a membrane reactor that utilizes polymer photosensitizers to generate singlet oxygen (O-1(2)) for organic reactions. The reactor significantly accelerates oxidation reactions and polymerization reactions, showing potential for green industrial use.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Mildred S. Cano-Velazquez, Juan A. Hernandez-Cordero
Summary: This study presents a simple method for fabricating polymer end-capped fiber optic sensors with highly reproducible features. The use of PDMS allows for consistent dimensions and spectral features in the fiber devices. The FFPI sensors show excellent performance in measuring refractive index of different liquids and can effectively account for temperature effects on the measurements.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Meng Wu, Chenhui Yin, Zhixin Liu, Mengyuan Wang, Qijun Sun, Na Niu, Ligang Chen
Summary: This study developed an anthracene-based fluorescent biosensor using bovine serum albumin as a bio-template to specifically detect and monitor the levels and distribution of indole-3-acetic acid (IAA) in plants. The biosensor has high spatial and temporal resolution, enabling specific trace sensing of IAA in the presence of multiple structural analogues, and visual monitoring of endogenous IAA signals.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Balaji Babu, Azole Sindelo, John Mack, Tebello Nyokong
Summary: The synthesis and characterization of two novel chlorin dyes, as well as their photodynamic properties on cancer cells and bacteria, were investigated. One of the dyes demonstrated better photocytotoxicity and bacterial inactivation, indicating its potential for future therapeutic applications.
Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Chemistry, Applied
Julia Becker-Jahn, Jan Griebel, Sarah Glass, Pauline Langowski, Selina Niess, Agnes Schulze
Summary: By immobilizing two different photosensitizer molecules on a commercial polyethersulfone membrane using electron beam-mediated grafting, highly active membrane surfaces capable of generating singlet oxygen upon light activation were created. These photoactive membranes were able to efficiently degrade pharmaceuticals like propranolol and ranitidine, converting them into transformation products with high singlet oxygen generation activity. The immobilization process enhanced surface hydrophilicity and permeance while maintaining pore size and morphology, leading to effective degradation of the pharmaceuticals.
Article
Biochemistry & Molecular Biology
Adrian Truszkiewicz, Dorota Bartusik-Aebisher, Lukasz Wojtas, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka, David Aebisher
Summary: Artificial intelligence has entered the field of medical research, with neural networks being included in diagnostic instruments. Deep learning algorithms are particularly important in oncology, and this paper presents the use of neural networks to analyze MRI images for relaxometry. The application of a neural network helps eliminate aerated spaces in MRI images, and the algorithm has been implemented in MATLAB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zuzanna Bober, Rafal Podgorski, David Aebisher, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka, Dorota Bartusik-Aebisher
Summary: Noninvasive measurements of H-1 Magnetic Resonance Imaging (MRI) relaxation times were used to evaluate Trastuzumab delivery in a 3D cell culture construct. The study utilized a bioreactor for the cell cultures and compared normal and breast cancer cells. Results showed that the relaxation time of cancer cells was lower than normal cells before and after treatment. The use of H-1 MRI relaxation times allows for the visualization of cell viability in response to treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Alexander Greer, Jean Cadet
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Caroline Coradi Tonon, Alessandra Nara de Souza Rastelli, Chathuna Bodahandi, Goutam Ghosh, Tayyaba Hasan, Qianfeng Xu, Alexander Greer, Alan M. Lyons
Summary: Limited options exist for the treatment of periodontitis, and current methods like scaling and root planing are not sufficient. This study evaluated the effectiveness of a new superhydrophobic antimicrobial photodynamic therapy device as an adjuvant to scaling and root planing. The device significantly reduced periodontal pathogens, improved clinical parameters, and showed promising healing outcomes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Domka, Dorota Bartusik-Aebisher, Wiktoria Mytych, Klaudia Dynarowicz, David Aebisher
Summary: Head-neck cancers, particularly squamous cell carcinoma, have a high incidence rate worldwide and pose challenges in treatment. Photodynamic therapy (PDT) shows promise as a therapeutic approach for head, neck, and brain diseases, as it can induce apoptosis and necrosis in tumor cells through the generation of singlet oxygen or reactive oxygen radicals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Andreis M. Durantini, Lloyd Lapoot, Shakeela Jabeen, Goutam Ghosh, Johirul Bipu, Serah Essang, Britney C. Singh, Alexander Greer
Summary: Although silica surfaces have been used in organic oxidations for the production of peroxides, the study of airborne singlet oxygen at interfaces is limited and has not found widespread advantages. In this study, prenyl phenol-coated silica and delivery of singlet oxygen through the gas phase were used to achieve significant selectivity for dihydrofuran formation over allylic hydroperoxide formation. The mechanism of selectivity was further investigated using air/nanoparticle interfaces and density functional theory calculations.
Review
Biochemistry & Molecular Biology
Malgorzata Oleksy, Klaudia Dynarowicz, David Aebisher
Summary: The introduction of new biomaterials has greatly improved the quality of human life in terms of health by enabling the development of fields such as medicine, tissue, and regenerative engineering. These materials, with their specific features like biocompatibility and ease of sterilization, have led to the availability of various implants, prostheses, tools, and surgical equipment. The use of biomaterials in tissue engineering and regenerative medicine strategies aims to restore damaged tissues by providing an ideal rate of regenerated tissue development.
Article
Biochemistry & Molecular Biology
Lloyd Lapoot, Shakeela Jabeen, Andres M. Durantini, Alexander Greer
Summary: This article presents a density functional theoretical (DFT) study on an O-1(2) oxidation process that leads to the formation of dihydrobenzofuran from glycocitrine, a natural homoallylic alcohol. The results indicate the interconversion between glycocitrine and an iso-hydroperoxide intermediate [R(H)O+-O-], which plays a crucial role in subsequent chemistry. The formation of allylic hydroperoxides through an O-1(2) 'ene' reaction is unlikely, and instead, the curvature of the glycocitrine ring facilitates the O-1(2) oxidation and the formation of the iso-hydroperoxide.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Malgorzata Oleksy, Klaudia Dynarowicz, David Aebisher
Summary: Three-dimensional printing technology has been used for over 30 years in various industries such as automotive and aerospace. Its application in medicine has been limited to anatomical models, due to material limitations. Recent advances in innovative materials have led to the flourishing use of 3D printing in medicine and pharmacy, with notable developments in implant design, personalized biomedical models, and bioprinting for regenerative medicine. This review aims to characterize popular 3D printing techniques.
Article
Biology
Grzegorz Chrzanowski, Grzegorz Pasternak, David Aebisher, Klaudia Dynarowicz, Angelika Mysliwiec, Dorota Bartusik-Aebisher, Barbara Sosna, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka, Rafal Filip
Summary: Crohn's disease is a chronic inflammatory bowel disease that cannot be fully cured. Quantitative and qualitative determination of metalloproteinases in inflammatory tissues is a useful diagnostic tool to differentiate inflammatory from non-inflammatory tissues in patients diagnosed with Crohn's disease.
Review
Biology
Grzegorz Pasternak, Grzegorz Chrzanowski, David Aebisher, Angelika Mysliwiec, Klaudia Dynarowicz, Dorota Bartusik-Aebisher, Barbara Sosna, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka, Rafal Filip
Summary: Crohn's disease is a chronic inflammatory bowel disease that affects various parts of the human body. It causes a reduction in the functioning of the digestive system and significantly impacts quality of life. Accurate diagnosis requires a combination of methods including laboratory examinations, histopathology, and imaging techniques. Metalloproteinase analysis has also proved helpful in diagnosing changes associated with Crohn's disease.
Article
Biochemistry & Molecular Biology
Jennifer Otero-Gonzalez, Whitney Querini-Sanguillen, Daniel Torres-Mendoza, Ikhil Yevdayev, Sharon Yunayev, Kamrun Nahar, Barney Yoo, Alexander Greer, Denis Fuentealba, Jose Robinson-Duggon
Summary: This study reports on the formation of toluidine blue O (TBO) sulfoxide and investigates its mechanism using mass spectrometry (MS). The results indicate that the formation of TBO sulfoxide is a minor process, which occurs through a type I reaction. Additionally, the study also reveals the competitive nature between TBO photosulfoxidation and TBO photodemethylation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Przygoda, Dorota Bartusik-Aebisher, Klaudia Dynarowicz, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka, David Aebisher
Summary: This review explores the application of photodynamic therapy (PDT) in cancer treatment, emphasizing its precise targeting and protection of healthy tissue. The key role of singlet oxygen in initiating apoptosis and other cell death pathways is highlighted, along with the complex interactions of cellular components. The review concludes by emphasizing the opportunities and potential for optimizing PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Domka, Dorota Bartusik-Aebisher, Maria Przygoda, Klaudia Dynarowicz, Jerzy Tomik, David Aebisher
Summary: Photodynamic therapy (PDT) affects cancer treatment by activating hormonal response. PDT-treated tumors release stress signals that lead to adrenal activity and the release of glucocorticoids (GCs). These released hormones play important roles in anticancer therapy, including regulating the activity of inflammatory and immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Marek Biesiadecki, Sabina Galiniak, Marta Rachel, Agnieszka Bozek, David Aebisher
Summary: Asthma, the most common chronic inflammatory disease of the airways, is influenced by both genetic and environmental factors. Oxidative stress has been found to play a role in the progression of the disease.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)