期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 22, 页码 10228-10234出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo301851a
关键词
-
资金
- National Natural Science Foundation of China [90813012, 20932003, 21202072]
- Ministry of Science and Technology of China [2012ZX09504-001-003]
Herein, the organocatalytic asymmetric Michael/cyclization sequence of alpha-isothiocyanato imides and esters with a variety of unsaturated pyrazolones is presented, in general, affording functionalized spiropyrazolones containing three contiguous stereogenic centers in high levels of diastereo- and enantioselectivity (up to 20:1 dr and 99% ee). Moreover, the current protocol provides a highly efficient and convenient strategy that allows rapid enantioselective construction of diversely spiropyrazolone skeletons with high optical purity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据