期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 18, 页码 8000-8006出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo301246x
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资金
- Fogarty International Center of the U.S. National Institutes of Health [U01-TW007401]
Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.
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