期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 22, 页码 10375-10381出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo3020352
关键词
-
资金
- Ministerio de Economia y Competitividad [CTQ2010-14959]
- MICINN
The choice of the anion of an achiral TBD-derived guanidinium salt, used as cocatalyst for proline, allows reacting cycloketones with aromatic aldehydes and preparing either anti- or syn-aldol adducts with very high enantioselectivity. As a proof of principle, we show how the judicious choice of an additive allows individual access to all possible products, thus controlling the stereochemical outcome of the asymmetric aldol reaction. The origin of the syn diastereoselectivity unfolds from an unusual equilibrium process coupled to the enamine-based catalytic cycle standard for proline.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据