期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 77, 期 15, 页码 6583-6599出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo3011039
关键词
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资金
- Ministerio de Ciencia y Tecnologia [CTQ2009-12168]
- UAM-Comunidad de Madrid [CCG08UAM/PPQ-4235]
- Comunidad de Madrid (AVANCAT) [S-2009-PPQ-1634]
- Ministerio de Ciencia e Innovacion
- Ramon y Cajal contract
In this work, we report the use of the asymmetric intramolecular Pauson-Khand reactions of 4-aryl-4-cyano-1,6-enynes for obtaining enantiomerically enriched bicyclo[3.3.0]octenones, and the influence of both the quaternary stereocenter and the sulfur functions located at ortho-position of the aryl group, on their stereoselectivity and reactivity. The sulfenyl derivatives bearing substituted or unsubstituted triple bonds and mono- and disubstituted alkene moieties afford bicyclo[3,3,0]octenones in high yields with complete diastereocontrol. These results are explained by assuming the association of the lone electron pair at sulfur to the Co-alkyne complexes.
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