4.7 Article

Synthesis of Multisubstituted Enamides via Pd-Catalyzed Chloroallylation of Ynamides

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JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 20, 页码 8524-8529

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AMER CHEMICAL SOC
DOI: 10.1021/jo2015278

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资金

  1. National Natural Science Foundation of China [20902084, 21172199]
  2. Science and Technology Office in Zhejiang Province [2010R10016]

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An atom-economic approach to the regio- and stereoselective assembly of highly substituted enamides is described via the Pd-catalyzed chloroallylation of ynamides at room temperature, which offers a simple and practical alternative to the stereodefined multisubstituted enamides.

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