期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 76, 期 1, 页码 281-284出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo101699r
关键词
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资金
- Program for Academic Leader in Wuhan Municipality [200851430486]
- National Natural Science Foundation of China [21072069, 21002036]
A novel organocatalytic asymmetric cyclopropanation of beta,gamma-unsaturated alpha-ketoesters with stabilized sulfur ylides using C-2-symmetric urea as a hydrogen-bond catalyst has been described. This reaction allows an efficient access to 1,2,3-trisubstituted cyclopropane derivatives in moderate to good yields with up to 16:1 dr and 90: I 0 er under mild reaction conditions. The mechanism study proved that the high stereoinduction originated from the cooperative effect of the hydrogen-bond catalyst.
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