☆ 4.7 Article

Palladium(II)-Catalyzed Synthesis of Functionalized Indenes from o-Alkynylbenzylidene Ketones

JOURNAL OF ORGANIC CHEMISTRY (2011)

期刊

JOURNAL OF ORGANIC CHEMISTRY

卷 76, 期 5, 页码 1491-1494

出版社

AMER CHEMICAL SOC

DOI: 10.1021/jo1023574

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Chemistry, Organic

资金

National Natural Science Foundation of China [20732005, 20872158]
Chinese Academy of Sciences
Major State Basic Research Program [2006CB806105]

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摘要

An efficient method for the synthesis of functionalized indenes from o-alkynylbenzylidene ketones under palladium(II) catalysis was developed. The reaction is initiated by trans-nucleopalladation of alkynes, followed by conjugate addition and quenched by protonolysis of the carbon palladium bond. With acetate and halide ions as nucleophiles, 3-acetoxy- and 3-halogen-substituted indenes could be obtained in high yields.

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