☆ 4.7 Article

Glucosamine-Based Primary Amines as Organocatalysts for the Asymmetric Aldol Reaction

JOURNAL OF ORGANIC CHEMISTRY (2011)

期刊

JOURNAL OF ORGANIC CHEMISTRY

卷 76, 期 9, 页码 3502-3505

出版社

AMER CHEMICAL SOC

DOI: 10.1021/jo1023156

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Chemistry, Organic

资金

DST, New Delhi [SR/S1/OC-15/2005]
UGC

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摘要

Glucosamine derivatives have been synthesized starting from commercially available N-acetyl-D-glucosamine/glucosamine hydrochloride and have been employed successfully as efficient organocatalysts for the direct asymmetric aldol reaction between cyclohexanone and aryl aldehydes having diversified substituents. Furthermore, the anomeric effect of various groups present at the anomeric position on the catalytic activity of these organocatalysts was also studied.

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