Article
Chemistry, Organic
Yunhui Wan, Huaimo Wu, Linhao Xia, Song Liu, Yi Ren, Hongxi Xu, Changwu Zheng
Summary: A unified approach for the construction of the bicyclo[3.3.1]nonane-2,4,9-trione core of polycyclic polyprenylated acylphloroglucinols (PPAPs) was reported. This method involves sequential Dieckmann condensation reactions and has been successfully applied to the synthesis of various natural and synthetic compounds. Key steps of this approach include oxidative olefin cleavage and decarboxylative allylation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Jessica C. Neville, Michelle Y. Lau, Tilo Sohnel, Jonathan Sperry
Summary: Chitin-derived platforms have emerged as valuable chemical entities for nitrogenous fine chemicals construction independent of the Haber ammonia process. However, much of the research in this field has focused on achiral platforms, limiting the access to enantiopure, bio-based nitrogenous chemical space. In this study, dihydroxyethyl acetamidofuran (Di-HAF), a chiral synthon easily available from chitin, has been transformed into epi-leptosphaerin, a marine alkaloid. This work extends the concept of Haber-independent synthesis to enantiopure chemical space that is not routinely accessible from existing achiral platforms.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Fangzhi Han, Guangju Liu, Xiuhe Zhao, Shunshun Du, Yahui Ding, Quan Zhang, Huiting Deng, Liang Wang, Yue Chen
Summary: In this study, the total synthesis of rakicidin F was successfully achieved, allowing the determination of its stereogenic centers. The macrolactonization reaction of rakicidin precursor was also investigated, with steric hindrance near C16-OH identified as a possible cause for the unsuccessful results.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Hongjun Jang, Soo Yeon Kwak, Dongjoo Lee, Juan Alegre-Requena, Hyoungsu Kim, Robert S. Paton, Deukjoon Kim
Summary: This study successfully achieved the introduction of halogens in the synthesis of (+)-srilankenyne through a sequence-sensitive process guided by conformational analysis and experimental studies.
Article
Chemistry, Multidisciplinary
Akane Yamagishi, Yuki Egoshi, Makoto T. T. Fujiwara, Noriyuki Suzuki, Tohru Taniguchi, Ryuuichi D. D. Itoh, Yumiko Suzuki, Yoshiro Masuyama, Kenji Monde, Toyonobu Usuki
Summary: This study describes the total synthesis of foeniculoxin and demonstrates its phytotoxicity in plant cells. Foeniculoxin induces various defects in Arabidopsis thaliana leaf cells and causes aggregation of mitochondria around chloroplasts.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Jiawei Sun, Wei Gu, He Yang, Wenjun Tang
Summary: This study achieved the enantioselective total synthesis of parnafungin A1 and 10a-epi-hirtusneanine, utilizing Suzuki-Miyaura cross-coupling and highly diastereoselective oxa-Michael addition to construct their biaryl cores, along with other key reactions and innovative strategies in total synthesis.
Article
Chemistry, Organic
Fangzhi Han, Guangju Liu, Xuhai Zhang, Yahui Ding, Liang Wang, Yijing Wu, Yue Chen, Quan Zhang
Summary: For the first time, the 15-membered cyclic depsipeptide boholamide A and an epimer were prepared by total synthesis, leading to a revision of the C6 stereochemistry in the original proposed structure. The revised boholamide A was synthesized in 16 linear steps with an overall yield of 5.46%, facilitating investigations into its potential as a hypoxia-selective anticancer agent.
Article
Chemistry, Multidisciplinary
Peilin Tian, Wenkang Ye, Xiayan Zhang, Yi Tong, Pei-Yuan Qian, Rongbiao Tong
Summary: The increase in antibiotic resistance necessitates the development of new antibiotics with novel molecular structures and mechanisms of action. However, the discovery of new antibiotics and their progression into clinical use have been limited in recent decades. The potent anthracimycin antibiotic represents a significant advancement in this field, with its unique structural features and excellent biological activity against various bacteria, including drug-resistant strains. Researchers have successfully achieved the total synthesis of anthracimycin through a 10-step asymmetric synthesis, providing a reliable supply for further studies and allowing the preparation of analogues for structure-activity relationship studies.
Article
Chemistry, Organic
Xueying Wang, Yeelin Phang, Jiling Feng, Song Liu, Hong Zhang, Wenwei Fu, Hua Zhou, Gang Xu, Hongxi Xu, Changwu Zheng
Summary: The asymmetric total synthesis of five biologically significant polycyclic polyprenylated acylphloroglucinols (PPAPs), including garcinol and cambogin, was achieved through a highly diastereoselective and stereodivergent strategy. An efficient cascade Dieckmann cyclization was employed to construct the bicyclo[3.3.1]nonane core in one step. The synthesis provided a general approach toward the chiral endo-type B PPAPs and their C-30 diastereomers in a single sequence, which resolved the challenges of the absolute configuration determination/structural revision of PPAPs bearing exocyclic stereocenters.
Article
Chemistry, Multidisciplinary
Livia Dikosova, Barbora Otoskova, Tomas Malatinsky, Jana Dohanosova, Maria Kopacova, Anna Durinova, Lucie Smutna, Frantisek Trejtnar, Robert Fischer
Summary: This study successfully synthesized two polyhydroxylated pyrrolizidine alkaloids using a specific synthetic method, confirming their structure, stereochemistry, and biological activity. This research has the potential to provide important insights for further studies in related fields.
Article
Chemistry, Organic
Dattatraya H. Dethe, Appasaheb K. Nirpal
Summary: An efficient and convergent total synthesis of (+/-)-japonicol B and (-)-japonicol C has been achieved, utilizing Lewis acid-catalyzed Friedel-Crafts reaction for C-C and C-O bond formations, one pot Pd(OH)(2)/C-catalyzed isomerization/hydrogenation, and site selective sp(3) C-H oxidation as key steps in the synthetic route.
Article
Chemistry, Organic
Ramagonolla Kranthikumar
Summary: This study achieved a short and enantioselective synthesis of the 19-epi-BE-43547 A(2) chiral framework in a high yield. The synthetic strategy involved innovative methods such as Julia-Kocienski olefination and Z to E isomerization of olefin using a novel UV flow reactor. Additionally, unprecedented oxygen mediated hydroboration and the Krapcho decarboxylation of beta-keto lactone were observed.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
David A. Evans, Jason J. Beiger, Jason D. Burch, Peter H. Fuller, Frank Glorius, Egmont Kattnig, David A. Thaisrivongs, William C. Trenkle, Joseph M. Young, Jing Zhang
Summary: The total syntheses of aflastatin A and its C3-C48 degradation fragment have been achieved, revealing a structural misassignment in the naturally derived degradation product. The revised absolute configurations of six stereogenic centers were also confirmed in this study.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Soo Yeon Kwak, Iljin Shin, Hongjun Jang, Youngjik Park, Seongju Lim, Dongjoo Lee, Hyoungsu Kim, Deukjoon Kim
Summary: This study describes the highly stereoselective total synthesis of Laurencia C15 acetogenins (3Z)- and (3E)-elatenynes, utilizing various strategies and reactions to obtain the desired products.
Article
Chemistry, Multidisciplinary
Xiangtao Chen, Lei Yu, Huijing Wang, Wen Zhang, Pei Tang, Fener Chen
Summary: A concise method is presented for the stereoselective total synthesis of (+/-)-vindeburnol and its epimer, utilizing Baeyer-Villiger oxidation and a sequence of reactions to achieve high-level diastereocontrol.
CHEMICAL COMMUNICATIONS
(2021)
Article
Oncology
Ruijie Zhang, Xiankai Huo, Qian Wang, Juntao Zhang, Shaofeng Duan, Quan Zhang, Shicai Zhang
Summary: The study aimed to explore the feasibility and performance of machine learning-based radiomics models in predicting the expression of TTF-1 in NSCLC. The results showed that the models constructed by the LASSO method demonstrated satisfactory performance in the test set, providing a potential tool for predicting TTF-1 expression in NSCLC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Qiubing Ren, Heng Li, Mingchao Li, Juntao Zhang, Ting Kong
Summary: This paper presents an online monitoring model for dam displacement behavior that can continuously track the behavior and improve prediction performance through multi-scale residual error correction. The proposed model outperforms benchmark models in displacement prediction and accurately tracks the dynamic variations of displacement data.
ADVANCED ENGINEERING INFORMATICS
(2023)
Article
Optics
Wanbin Zhang, Baosheng Li, Jinjin Song, Shuyu Zhao, Jianquan Li
Summary: We propose a new method called three-pack frequency-selective incoherent holography, which can achieve compressed holography with lossless magnification and resolution. The frequency-selective reconstruction process removes the conjugate and DC terms along with the interception of the object wave. Experimental results demonstrate the potential of this method in compressed holography, extended field of view, and slice tomography.
Article
Oncology
Kailun Xu, Xiaoyang Yin, Biting Zhou, Xi Zheng, Hao Wang, Jing Chen, Xue Cai, Huanhuan Gao, Xiaoming Xu, Liuhong Wang, Li Shen, Tiannan Guo, Shu Zheng, Baosheng Li, Yingkuan Shao, Jian Wang
Summary: By analyzing the proteomic profiles of locally advanced rectal cancer patients, we identified FOSL2 as a promising biomarker to predict the effectiveness of neoadjuvant chemoradiotherapy. Patients who achieved pathological complete response had higher levels of tumor immune infiltration, especially CD8+ T cell infiltration, before treatment. High expression of FOSL2 predicted pathological complete response and was associated with long-term disease-free survival.
Article
Automation & Control Systems
Chuandong Qin, Baosheng Li, Baole Han
Summary: This paper proposes a novel parallel optimization algorithm based on a shared-memory environment for solving the SVM classifier in brain tumor detection. Experimental results show that the algorithm extracts features of brain tumor MRI more effectively than the wavelet transform method, improving the accuracy and efficiency of brain tumor detection.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Oncology
Changjie Shao, Juntao Zhang, Jing Guo, Liang Zhang, Yuhan Zhang, Leiyuan Ma, Chuanxin Gong, Yaqi Tian, Jingjing Chen, Ning Yu
Summary: This study developed and validated a radiomics nomogram to predict the survival of patients with pancreatic ductal adenocarcinoma (PDAC) after high-intensity focused ultrasound (HIFU) treatment. The results showed that the radiomics score and tumor size were independent risk factors for the survival of PDAC patients. The combination of radiomics score and clinicopathological factors had better predictive value compared to clinical and radiomics models. The radiomics nomogram demonstrated improved discrimination, calibration, and clinical practicability.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinshan Cao, Haoran Yang, Xin Luo, Linxuan Zou, Qiang Zhang, Qilin Li, Juntao Zhang, Xiangfeng Li, Yan Shi, Chenwang Jin
Summary: This study utilized radiomic techniques with clinical examinations to assess recurrence in HCC and developed a Cox nomogram to assess the risk of postoperative recurrence. The combined radiomic model, which included features from radiomic VOIs and clinical imaging, provided the highest performance in assessing the survival of HCC.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Electrochemistry
Juntao Zhang, Yazhen Wang, Xia Liang, Haihong Wu, Hui Li, Liyong Tong
Summary: A flexible and bendable carbon fiber battery (FBCFB) was prepared for the first time in this study, which showed good energy storage and stable electrochemical performance. The FBCFB consisted of a nickel-plated positive electrode, a copper foil negative electrode, a separator, and a liquid electrolyte.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiabing Gu, Qingtao Qiu, Jian Zhu, Qiang Cao, Zhen Hou, Baosheng Li, Huazhong Shu
Summary: This study developed a deep-learning-based method to combine FDG-PET and CT images for producing pulmonary perfusion images, which is beneficial for functional lung avoidance radiation therapy. The method achieved higher accuracy compared to methods based on metabolic information alone, and can be utilized for pulmonary perfusion volume segmentation and treatment plan optimization.
Article
Oncology
Yang Li, Zhenjiang Li, Jian Zhu, Baosheng Li, Huazhong Shu, Di Ge
Summary: This study validates the effectiveness of linear regression for motion prediction in 2D cine-MR and proposes an online gating signal prediction scheme for MR-guided radiotherapy. The results show that linear regression outperforms other methods in terms of prediction accuracy, and the proposed adaptive linear regression model performs the best in all studied metrics.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Cong Liu, Pengyue Shi, Zhenjiang Li, Baosheng Li, Zengjun Li
Summary: This study aimed to optimize the risk stratification for DLBCL patients by integrating PET/CT metrics and genetic mutations. A training cohort of 94 DLBCL patients and an independent cohort of 45 DLBCL patients were analyzed. The baseline TMTV and SDmax were calculated and TP53 status was found to significantly affect complete remission.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pei Nie, Juntao Zhang, Wenjie Miao, Shaofeng Duan, Tongyu Wang, Ju Zhang, Jinyang Gu, Ning Wang, Ran Zhang, Ximing Wang, Guangjie Yang, Wei Rao, Zhenguang Wang
Summary: The radiomics-based intratumoral heterogeneity (ITH) is associated with the recurrence risk in hepatocellular carcinoma (HCC) patients after liver transplantation (LT) and provides incremental value to the existing risk criteria. Incorporating radiomics-based ITH in HCC risk criteria may improve candidate selection and surveillance.
EUROPEAN RADIOLOGY
(2023)
Article
Environmental Sciences
Chengzhi Xu, Xiao Xiao, Chaonan Cai, Qunpeng Cheng, Lian Zhu, Juntao Zhang, Benmei Wei, Haibo Wang
Summary: In this study, carbon dots (CDs) were prepared from waste fish scales, and the effects of hydrothermal and microwave methods on their fluorescence properties and structures were evaluated. The microwave method facilitated self-doping of nitrogen, but resulted in incomplete dehydration and condensation, forming nanosheet-like CDs with emission behavior independent of excitation. The CDs prepared using the conventional hydrothermal method showed higher quantum yields and excitation wavelength-dependent emission behavior due to the dehydration and condensation of organic matter at controlled high temperature and sealed environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Juntao Zhang, Juan Ren, Shuiqing Hu
Summary: This paper proposes a novel deep learning framework for the classification and detection of AFM images. The framework trains a neural network model to accurately identify and classify AFM images of different sample types. The proposed AI approach significantly reduces the time and labor cost in AFM quality analysis and has potential for extension to other applications.
2023 IEEE 23RD INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY, NANO
(2023)
Correction
Oncology
Yuzhong Cui, Wei Huang, Feng Du, Xiaoyang Yin, Lei Feng, Baosheng Li
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
