☆ 4.7 Article

Highly Selective Ylide-Initiated Michael Addition/Cyclization Reaction for Synthesis of Cyclohexadiene Epoxide and Vinylcyclopropane Derivatives

JOURNAL OF ORGANIC CHEMISTRY (2010)

期刊

JOURNAL OF ORGANIC CHEMISTRY

卷 75, 期 10, 页码 3454-3457

出版社

AMER CHEMICAL SOC

DOI: 10.1021/jo100306z

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Chemistry, Organic

资金

National Natural Science Foundation of China [20821002, 20932008]
Major State Basic Research Development Program [2006CB806105]
Chinese Academy of Sciences
Science and Technology Commission of Shanghai Municipality

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摘要

On the basis of the reactions of camphor-derived sulfur ylide with alpha,beta-unsaturated ketone, highly efficient and selective synthesis of optically active cyclohexadiene epoxides and vinylcyclopropanes with excellent diastereoselectivities, moderate to high enantioselectivities, and yields has been achieved.

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