期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 16, 页码 5733-5736出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo100757t
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资金
- Dutch Organisation for Scientific Research (NWO)
Phosphitylation of the side chain hydroxyl function of Fmoc protected tyrosine with 5'-phosphoramidites of suitably protected cytidine, adenosine, and guanosine, followed by oxidation gave three novel nucleotidylated amino acid building blocks. After protective group manipulation, these building blocks were used in a solid phase peptide synthesis to afford the nucleotidylated poliovirus proteins VPgpC, VPgpA, and VPgpG.
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