期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 10, 页码 3443-3446出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo1000912
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资金
- Grant Agency of AS CZ [IAA400720703]
- Ministry of Education [MSM0021620857, VZ0021627501]
- Agency of ASCR [IAA400720706]
We have prepared a full series of 1,6-anhydro-2,3,4-trideoxy-4-fluoro-2,3-epimino-beta-D-hexopyranoses. The key step was the reaction of azido sulfonates possessing a free C-4 hydroxyl with DAST and subsequent LiAlH4 reduction. Nucleophilic displacement of the hydroxyl activated by DAST proceeded without rearrangement and with moderate to good yields. A convenient synthesis of D-manno-epimine from a readily available 3-benzylamino derivative was also developed.
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