期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 75, 期 21, 页码 7443-7446出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo101436f
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资金
- Ministerio de Educacion y Ciencia (MEC)
- FEDER [CTQ2007-61436/BQU]
- Junta de Castilla y Leon [BU021A09, GR-172]
- MEC-FPU
An efficient synthesis of 3-halo-7-oxygen-functionalized benzo[b]thiophenes bearing different substituents at C-2 has been developed from N,N-diethyl O-3-halophenylcarbamates. The key steps are an ortho-lithiation reaction, which gives rise to 3-halo-2-sulfanylphenol derivatives, and a electrophilic cyclization. The subsequent functionalization of the prepared halobenzothiophenes allows the access of a wide variety of 2,3,7-regioselectively functionalized benzo-[b]thiophenes in good overall yields.
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