期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 1, 页码 289-297出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo802180h
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资金
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Merck Frosst Centre for Therapeutic Research for an Industrial Research Chair
- University of Toronto
- Deutsche Forschungsgemeinschaft (DFG)
A palladium-catalyzed, norbornene-mediated ortho-alkylation reaction of aryl iodides with secondary alkyl halides is described. Intermolecular or intramolecular ortho-alkylation proceeds in a domino process with various termination steps, generating two new carbon-carbon or carbon-nitrogen bonds in one pot, to afford an array of polycyclic heterocycles. The use of enantioenriched substrates has shown that this palladium-catalyzed reaction is stereospecific, proceeding with minimal erosion of ee.
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