☆ 4.7 Article

Synthesis of a Carboxylate Functionalized Bis-Amino Acid Monomer

JOURNAL OF ORGANIC CHEMISTRY (2009)

期刊

JOURNAL OF ORGANIC CHEMISTRY

卷 74, 期 10, 页码 3652-3658

出版社

AMER CHEMICAL SOC

DOI: 10.1021/jo802679n

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Chemistry, Organic

资金

NIH/NIGMS [GM067866]

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Protocol

Reagent

摘要

The synthesis of the first functionalized bis-amino acid monomer proAc(2S3S4R) 1 that carries an acetyl side chain is presented. This monomer was incorporated into oligomer 3 and the solution phase structure was determined by using two-dimensional nuclear magnetic resonance. The solution structure confirmed the intended connectivity and stereochemistry of the oligomer. This first functionalized bis-amino acid represents a milestone toward functionalized bis-peptide nanostructures for catalytic, molecular recognition, and nanotechnology applications.

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