期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 1, 页码 431-434出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo801968p
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资金
- Spanish Government
- Universidad Autonoma de Madrid [CTQ2006-06741/BQU, CCG07-UAM/PPQ-1709]
Optically pure cyano tert-alkyl sulfones have been obtained by organocatalytic enantioselective Michael addition of alpha-substituted cyanosulfones to vinyl ketones using cinchona alkaloids as catalysts. The best results were obtained for p-trifluorophenylsulfones by using VIII as catalyst in toluene at -40 degrees C. Reactions proved to be applicable for a variety of alpha,beta-unsaturated ketones. affording alpha,alpha-disubstituted cyanosulfones in excellent yields with er's up to 90:10.
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