Article
Chemistry, Organic
Li-Wen Shen, Zhen-Hua Wang, Yong You, Jian-Qiang Zhao, Ming-Qiang Zhou, Wei-Cheng Yuan
Summary: An unprecedented (3+1) cyclization of alpha-nitro-sostyrenes, generated in situ from alpha-bromooximes, and N-tosyloxycarbamates was developed, enabling the synthesis of a range of structurally unique and hitherto unexplored 2,3-dihydrodiazete N-oxides in moderate to high yields. The products possess a highly strained four-membered ring structure containing two nitrogen atoms. The synthetic applicability of the products was also demonstrated by many important conversions to diverse nitrogen-containing compounds.
Review
Chemistry, Multidisciplinary
Salvador Mastachi-Loza, Tania I. Ramirez-Candelero, Luis J. Benitez-Puebla, Aydee Fuentes-Benites, Carlos Gonzalez-Romero, Miguel A. Vazquez
Summary: Chalcones are aromatic ketones that have a wide range of biological activity and are biogenetic precursors of other important molecules. Due to their structural diversity and ease of synthesis, they are often used as building blocks for chemical transformations. They can participate in nucleophilic additions and Diels-Alder reactions, and novel methodologies have been developed for [4+2] cycloadditions using chalcones as electron systems.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Christian E. Ziegler, Moritz Graf, Makoto Nagaoka, Achim M. Goepferich
Summary: The eight-armed poly(ethylene glycol) (PEG) hydrogels cross-linked via inverse electron demand Diels-Alder reaction between norbornene and tetrazine groups are promising for long-term protein delivery. By introducing hydrolyzable functional groups, the degradation time and release rate of the hydrogels can be controlled.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Applied
Trung Thang Vu, Muhammad Gulfam, Sung-Han Jo, Sang-Hyug Park, Kwon Taek Lim
Summary: Novel injectable and reduction-responsive hydrogels were successfully prepared in this study. The hydrogels exhibited high swelling ratios, porous morphology, excellent drug loading efficiency, and suitable mechanical properties. Drug release experiments showed that the hydrogels released the encapsulated drug in the presence of glutathione and exhibited anti-tumor activity against cancer cells. These hydrogels have great potential as a biomaterial for stimuli responsive drug delivery applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Kristine Bertheussen, Merel van de Plassche, Thomas Bakkum, Berend Gagestein, Iakovia Ttofi, Alexi J. C. Sarris, Herman S. Overkleeft, Mario van der Stelt, Sander van Kasteren
Summary: In the field of lipid research, bioorthogonal chemistry has enabled the study of lipid uptake and processing in living systems with minimal interference from biological properties. This study introduces a new bioorthogonal probe for investigating unsaturated free fatty acids in live cells. The probe is taken up by dendritic cells without toxicity and can be visualized using a specific reaction. It can also be used to identify changes in protein oleoylation after immune cell activation. Moreover, it can be integrated into a multiplexed bioorthogonal reaction workflow for simultaneous imaging of multiple biomolecules in the cell using confocal microscopy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xu-Ge Si, Shi-Xiong Feng, Zhuo-Yan Wang, Xiaoyu Chen, Meng-Meng Xu, Yu-Zhen Zhang, Jun-Xiong He, Limin Yang, Quan Cai
Summary: Here, we demonstrate that the combination of Birch reduction and catalytic asymmetric Diels-Alder reaction is a powerful approach for the synthesis of diverse cis-decalin scaffolds. By utilizing a modified chiral bis(oxazoline) ligand/Cu-II complex, we efficiently generated a wide range of polysubstituted cis-decalin scaffolds. Mechanistic studies revealed the role of 1,3-cyclohexadienes as key intermediates and the origins of stereoselectivities in the Diels-Alder reaction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Vladimir Kardelis, Maria M. Denk, Alex Adronov
Summary: A soluble poly(tetrazine) polymer was prepared through Suzuki polycondensation, which can efficiently react with TCO derivatives via Diels-Alder click reactions. After oxidation, the resulting polymers showed enhanced fluorescence intensity and longer retention times, while maintaining relatively constant degrees of polymerization. Graft copolymers and cross-linked foam were easily prepared by reacting with TCO-functionalized poly(ethylene glycol) chains and a bis-TCO crosslinker, respectively.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yang Lu, Meng-Meng Xu, Zhi-Mao Zhang, Junliang Zhang, Quan Cai
Summary: The study presented a copper-catalyzed asymmetric IEDDA reaction for the synthesis of six-membered carbocycles, leading to the successful asymmetric total syntheses of cephanolides A and B.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Bonaldi, Marco Bortoluzzi, Stefano Zacchini, Guido Pampaloni, Fabio Marchetti, Lorenzo Biancalana
Summary: The chemistry of 1,2,4,5-tetrazines has attracted attention in the synthesis and application field. Recent studies have shown that regioselective reactions with alkynes and alkenes are favored when the tetrazine ring is coordinated to certain metal centers. This study explores the reactivity of tetrazines with chalcogenocyanate anions and demonstrates the formation of new heterocycles. The resulting ruthenium complexes were characterized using various analytical and spectroscopic techniques.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jun-Xiong He, Xu-Ge Si, Qi-Tao Lu, Qian-Wei Zhang, Quan Cai
Summary: A unified approach for the synthesis of chiral heteroatom-containing bicyclic derivatives using lanthanide-catalyzed reactions has been reported. This method provides a step-economical synthetic platform for the synthesis of densely functionalized cis-hydroindoles and cis-hydrobenzofurans with high yields and enantioselectivities, and has demonstrated synthetic utility.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Nicole A. Carrillo Vallejo, Jonathan R. Scheerer
Summary: This study introduces a novel method for the synthesis of 1,4-oxazinone derivatives by Staudinger reductive cyclization and intermolecular cycloaddition/cycloreversion reactions. The synthesized compounds can be applied to the preparation of ErbB4 receptor inhibitors.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Guanghao Huang, Cyrille Kouklovsky, Aurelien de la Torre
Summary: The Inverse-electron-demand Diels-Alder (IEDDA) reactions using electron-poor 2-pyrones as electrophilic dienes have been extensively studied in the past fifty years. These reactions provide efficient access to bridged bicyclic lactones and their derivatives, as well as polysubstituted aromatic compounds. They have been used for synthesizing biologically active natural products and drug candidates, and different catalytic methods have been explored for their applications in total synthesis.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jacky C. H. Chu, Clarence T. T. Wong, Dennis K. P. Ng
Summary: In this study, a novel dual receptor-mediated bioorthogonal activation approach was developed to enhance the tumor specificity of photodynamic therapy. By targeted delivery and specific activation of photosensitizers, the photodynamic action was confined to cancer cells that overexpress both the biotin receptor and epidermal growth factor receptor (EGFR).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Ahmet Cetinkaya, Ali Enis Sadak, Mehmet Menaf Ayhan, Yunus Zorlu, Muhammet U. Kahveci
Summary: The study developed a synthetic approach relying on the inverse electron demand Diels-Alder (IEDDA) reaction for the preparation of a porphyrin-based covalent organic polymer (PoTz-COP), showing a high CO2/N-2 adsorption selectivity and stability at various ratios and temperatures.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Lisa Maria Haiber, Markus Kufleitner, Valentin Wittmann
Summary: The IEDDA reaction is a bioorthogonal ligation reaction that is emerging as a versatile tool in metabolic glycoengineering. It allows for the introduction of unnatural sugar derivatives with chemical reporter groups into cellular glycans, enabling visualization or isolation of glycoconjugates.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
James D. Cuthbertson, Richard J. K. Taylor
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Chemistry, Organic
James D. Cuthbertson, Andrew A. Godfrey, William P. Unsworth, Richard J. K. Taylor
Article
Chemistry, Medicinal
Natalie Fisher, Michael G. Edwards, Ryan Hemming, Steven M. Allin, John D. Wallis, Philip C. Bulman Page, Michael J. Mckenzie, Stefanie M. Jones, Mark R. J. Elsegood, John King-Underwood, Alan Richardson
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Organic
Richard G. Doveston, Rene Steendam, Stuart Jones, Richard J. K. Taylor
Article
Chemistry, Organic
William P. Unsworth, Christiana Kitsiou, Richard J. K. Taylor
Article
Chemistry, Organic
William P. Unsworth, Katherine A. Gallagher, Mickael Jean, Jan Peter Schmidt, Louis J. Diorazio, Richard J. K. Taylor
Article
Chemistry, Organic
David J. Burns, Stefan Mommer, Peter O'Brien, Richard J. K. Taylor, Adrian C. Whitwood, Shuji Hachisu
Article
Chemistry, Organic
Philip G. E. Craven, Richard J. K. Taylor
Editorial Material
Chemistry, Organic
Richard J. K. Taylor
Article
Chemistry, Organic
Richard G. Doveston, Richard J. K. Taylor
TETRAHEDRON LETTERS
(2012)
Article
Chemistry, Organic
Monique Luethy, Richard J. K. Taylor
TETRAHEDRON LETTERS
(2012)
Article
Chemistry, Organic
Philip G. E. Craven, Richard J. K. Taylor
TETRAHEDRON LETTERS
(2012)
Article
Chemistry, Organic
Catherine L. Moody, Vilius Franckevicius, Pauline Drouhin, Johannes E. M. N. Klein, Richard J. K. Taylor
TETRAHEDRON LETTERS
(2012)
Article
Chemistry, Medicinal
Natalie Fisher, Timothy Hilton-Bolt, Michael G. Edwards, Katherine J. Haxton, Michael McKenzie, Steven M. Allin, Alan Richardson
ACS MEDICINAL CHEMISTRY LETTERS
(2014)
Article
Chemistry, Organic
Richard J. K. Taylor
Summary: This article provides a personal overview of the author's research career from 1970 at the University of Sheffield to 2020 at the University of York, with stops at various institutions in between. It highlights selected research group achievements and offers reflections on an academic research career in the UK over the past 50 years.