期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 20, 页码 7889-7894出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo801032n
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资金
- JSPS [09306014]
- MEXT [16073207]
- Grants-in-Aid for Scientific Research [09306014, 16073207] Funding Source: KAKEN
Koshikamide B (1) has been isolated from two separate collections of the marine sponge Theonella sp. as the major cytotoxic constituent. Koshikamide B is a 17-residue peptide lactone composed of six proteinogenic amino acids, two D-isomers of proteinogenic amino acids, seven N-methylated amino acids, and two unusual amino acid residues. The unusual amino acids are N-delta-carbamoylasparagine and 2-(3-amino-2-hydroxy-5-oxopyrrolidin-2-yl)propionic acid (AHPP); the former is first found as the constituent of peptides, whereas the latter is a new amino acid residue. The N-terminus of koshikamide B is blocked by a methoxyacetyl group. The structure of koshikamide B (1) has been determined by interpretation of spectral data and analysis of chemical degradation products. Koshikamide B (1) exhibits cytotoxicity against P388 murine leukemia cells and the human colon tumor (HCT-116) cell line with an IC50 value of 0.45 and 7.5 mu g/mL, respectively.
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