A Simple One-Pot Preparation of Diazoacetoacetate Derivatives from Aldehydes

Diazoacetoacetate derivatives can be simply and efficiently prepared from aldehydes in a one-pot process involving, initial DBU-promoted aldol condensation with ethyl diazoacetate followed by in situ oxidation with IBX. Aryl, alkyl, and unsaturated aldehydes are all viable substrates.