期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 73, 期 10, 页码 3935-3937出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo8005733
关键词
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Organocatalytic cross-aldol reaction of methyl 4-oxobutyrate (2) and a variety of aldehydes 3 followed by reduction with NaBH4 has provided a one-pot, general and efficient method for the synthesis of 4-(hydroxyalkyl)-gamma-butyrolactones 1 with high diastereo- (dr > 24:1) and enantioselectivity (ee > 99%).
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