期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 44, 期 9, 页码 707-713出版社
WILEY
DOI: 10.1111/jop.12283
关键词
atomic absorption spectrophotometer; biological samples; cadmium; oral cancer; smokeless tobacco products
BackgroundIt has been reported that smokeless tobacco (SLT) chewing can lead to caners of oral cavity. In this study, the relationship between cadmium exposure via consumption of different SLT products by patients with oral cancer with related to referents belongs to different cities of Pakistan are investigated. MethodsThe cadmium in different types of SLT products (gutkha, mainpuri and snuff) consumed by studied population and biological samples (scalp hair and blood) of cancerous and healthy subjects were analyzed. Both referents and patients with cancer have same age group (ranged 30-60years), socioeconomic status, localities, and dietary habits. The concentrations of cadmium in SLT products and biological samples were measured by electrothermal atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by certified reference materials. ResultsIt was estimated that 10g intake of different types of gutkha, mainpuri, and snuff could contribute, 18-40%, 15.7-33.6%, and 14-68% of the provisional maximum tolerable daily intake of cadmium, respectively for adults (60kg). The results of present study showed that the mean value of cadmium was significantly higher in scalp hair and blood samples of patients with oral cancer as compared to those results obtained for referents (P<0.001). ConclusionsThe high exposure of cadmium due to consuming different SLT products may have synergistic effects with other risk factors associated for oral cancer.
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