期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 43, 期 3, 页码 199-204出版社
WILEY
DOI: 10.1111/jop.12121
关键词
laminin-5 2; myofibroblast; oral squamous cell carcinoma; tumor budding
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Fundo de Incentivo a Pesquisa da PUC Minas (FIP PUC Minas), Brazil
BackgroundOral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide. Laminin-5 gamma 2 chain (laminin-5 2) is a protein associated to a migratory phenotype in epithelial neoplastic cells. Stromal myofibroblasts also play a significant role in tumor invasion, due to its ability to modify the extracellular matrix. Tumor budding is a morphologic marker of tumor invasion. The aim of this study was to evaluate the expression of laminin-5 2 in OSCC and its association with intensity of tumor budding and density of stromal myofibroblasts. MethodsParaffin-embedded archival samples of 57 OSCC patients were evaluated. Immunohistochemistry was employed to detect laminin-5 2, alpha smooth muscle actin (marker of stromal myofibroblasts), and multicytokeratin (to identify OSCC cells in tumor budding evaluation). Laminin-5 2 expression and its association with intensity of tumor budding and density of stromal myofibroblasts were analyzed. Association among intensity of tumor budding and density of stromal myofibroblasts was also evaluated. ResultsHigher laminin-5 2 expression was associated with high-intensity tumor budding (P<0.05) and with higher density of stromal myofibroblasts (P<0.05). Moreover, high-intensity tumor budding was associated with higher density of stromal myofibroblasts (P<0.05). ConclusionsIn OSCC, higher laminin-5 2 expression is associated with high-intensity tumor budding and with higher density of stromal myofibroblasts, suggesting that this expression is related to the establishment of an invasive phenotype of neoplastic cells and a permissive environment for tumor invasion in this neoplasia.
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