Article
Dentistry, Oral Surgery & Medicine
Lucas Menezes dos Anjos, Aurelio de Oliveira Rocha, Gabriel Leonardo Magrin, Pedro Vitali Kammer, Cesar Augusto Magalhaes Benfatti, Julio Cesar Matias de Souza, Mariano Sanz, Bruno Alexandre Pacheco de Castro Henriques
Summary: This bibliometric study analyzed the characteristics of the 100 most cited articles on bone grafts in dentistry and found scientific progress on bone grafts in dentistry. The most prominent trend was the use of xenogeneic grafts for horizontal and/or vertical ridge augmentation.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ignacio Sanz-Sanchez, Ignacio Sanz-Martin, Alberto Ortiz-Vigon, Ana Molina, Mariano Sanz
Summary: According to the translation, bone-regenerative interventions aiming to restore deficient alveolar ridges have reported positive outcomes but are associated with risks of intraoperative and postoperative complications. The most common complication is exposure of the barrier membrane or graft, which may lead to infections, neurosensorial disturbances, hemorrhage, and pain. The management of these complications varies depending on the extent of exposure and presence of infections. Factors such as patient selection and surgical techniques also play a role in complication occurrence and treatment outcomes. Less invasive surgical interventions are recommended to prevent complications.
PERIODONTOLOGY 2000
(2022)
Article
Dentistry, Oral Surgery & Medicine
Stefan Krennmair, Lukas Postl, Uwe Yacine Schwarze, Michael Malek, Michal Stimmelmayr, Gerald Krennmair
Summary: This study compared new bone formation, graft stability, and clinical implant outcome between maxillary sinus grafting using DPBM and DBBM. The results showed that both materials had similar effects on new bone formation and graft stability, with good implant retention.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Chemistry, Physical
Luigi Canullo, Giampiero Rossi-Fedele, Francesca Camodeca, Maria Menini, Paolo Pesce
Summary: This study found that after complete bone grafting following extraction of impacted wisdom teeth, the experimental group had less bone loss in the socket compared to the control group filled with collagen sponge and blood clot. However, there was no statistically significant difference between the two groups in terms of periodontal parameters and soft tissue healing.
Review
Medicine, Research & Experimental
Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay, Moon Seungjoon, Moon Nyeo Park, Bonglee Kim
Summary: The PDGF/PDGFR pathway plays a crucial role in the growth and spread of several cancers. Targeting this pathway is a viable therapeutic approach for treating cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Chunxi Ge, Yiming Li, Fashuai Wu, Peter Ma, Renny T. Franceschi
Summary: Skeletal progenitor cells rely on collagen-binding integrins and discoidin domain receptors (DDR1 and DDR2) as collagen receptors for bone development and regeneration. This study evaluated specific triple helical peptides containing GFOGER and GVMGFO binding domains to stimulate DDR2 and integrin signaling, as well as osteoblast differentiation. The combination of these peptides cooperatively enhanced both DDR2 and focal adhesion kinase (FAK) signaling, leading to increased osteoblast differentiation. This finding suggests that scaffolds containing DDR and integrin-activating peptides could be a new approach for promoting bone regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vrisiis Kofina, Mutlu Demirer, Barbaros S. Erdal, Timothy D. Eubank, Vedat O. Yildiz, Dimitris N. Tatakis, Binnaz Leblebicioglu
Summary: This study found that a history of bone grafting alters the healing response of soft tissues following implant placement surgery. Soft tissue closure was slower in grafted bone (GG) areas, and blood perfusion recovery was slower in GG sites.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Immunology
Michael C. Tanner, Raban Arved Heller, Andreas Grimm, Stefan Zimmermann, Maximilian Pilz, Louisa Jurytko, Matthias Miska, Lars Helbig, Gerhard Schmidmaier, Patrick Haubruck
Summary: The study revealed a 9.04% incidence of occult infections in patients undergoing autologous bone grafting, impacting bone healing time and radiological outcomes to a non-significant extent. Factors such as diabetes, age, smoking, and higher BMI were found to have a significant negative influence on the outcome of bone grafting. Surgeons should be aware of the common occurrence of occult infections in treating recalcitrant non-unions and should pay special attention to high-risk patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Annica Proehl, Milijana Batinic, Said Alkildani, Michael Hahn, Milena Radenkovic, Stevo Najman, Ole Jung, Mike Barbeck
Summary: The study showed that the new hyaluronate containing bone substitute material has comparable bone healing capacity to the control xenogeneic BSM, with no significant differences in bone formation or inflammatory tissue responses. Both materials were fully biocompatible and allowed for gradual osteoconductive bone regeneration without differences in tissue reactions compared to a sham operation group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Hongzhou Shen, Lvyuan Li, Chenglong Zhang, Yang Chen, Hongbo Yu, Jiawen Si, Guofang Shen
Summary: A novel strategy of composite grafting with BMP2-loaded calcium phosphate cements (BMP2-CPC) and autogenous bone harvested by minimally invasive technique was developed and evaluated for alveolar bone grafting. The composite graft demonstrated satisfactory bone-repairing efficacy and improved resorption performance, making it an eligible alternative for application in alveolar bone grafting.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Qin Zhao, Yueqi Ni, Hongjiang Wei, Yiling Duan, Jingqiu Chen, Qi Xiao, Jie Gao, Yiqian Yu, Yu Cui, Simin Ouyang, Richard J. Miron, Yufeng Zhang, Chengtie Wu
Summary: This article provides a comprehensive overview of current knowledge and recent developments in ion incorporation into biomaterials for bone and periodontal tissue repair. It emphasizes the importance of precise ion introduction into biomaterials to address existing limitations and challenges, and highlights future prospects and opportunities for the development and optimization of biomaterials for bone tissue engineering.
PERIODONTOLOGY 2000
(2023)
Article
Medicine, General & Internal
Piotr Malara, Nadine von Krockow, Iwona Niedzielska, Beata Malara
Summary: This study found that using the proximal tibia for bone grafting procedures enables the acquisition of large amounts of cancellous bone with a low risk of early and late complications. Thus, the proximal tibia is an attractive donor site for bone grafting procedures in maxillofacial surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Taiki Nakajima, Akihiro Nakahata, Naoki Yamada, Keiko Yoshizawa, Tomoaki M. Kato, Mio Iwasaki, Chengzhu Zhao, Hiroshi Kuroki, Makoto Ikeya
Summary: Tendon self-renewal is rare, leading to limitations in reconstructive surgery. Researchers introduce an iPSC-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and demonstrate their contribution to motor function recovery after Achilles tendon injury.
NATURE COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yu-Ling Tsai, Jui-Pin Tsao, Chung-Li Wang, Evan Grodin, Jung-Jen Lin, Chun-Jung Chen, Chung-Han Ho, David Cochran, Jimmy Lian Ping Mau
Summary: This study compared the aesthetic outcomes and stability of peri-implant facial bone thickness and height between FDBA and DBBM using guided bone regeneration, showing similar results after 1 year of early implant placement.
JOURNAL OF PERIODONTOLOGY
(2022)