Review
Geriatrics & Gerontology
Nicholas Fuggle, Nasser Al-Daghri, Olivier Bock, Jaime Branco, Olivier Bruyere, Enrique Casado, Etienne Cavalier, Bernard Cortet, Maarten de Wit, Andrea Giusti, Philippe Halbout, Nicholas C. Harvey, Mickael Hiligsmann, Jean-Marc Kaufman, Andreas Kurth, Stefania Maggi, Radmila Matijevic, Salvatore Minisola, Santiago Palacios, Regis Pierre Radermecker, Friederike Thomasius, Sansin Tuzun, Nicola Veronese, John A. Kanis, Jean-Yves Reginster, Rene Rizzoli, Cyrus Cooper
Summary: Oral bisphosphonates are important in the treatment of osteoporosis, but poor adherence is a problem. New formulations aim to improve tolerance and adherence, potentially leading to better fracture outcomes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Taisa Nogueira Pansani, Lais Medeiros Cardoso, Luisa Ammirabile Augusto, Isabela Massaro Ribeiro, Carlos Alberto de Souza Costa, Fernanda Goncalves Basso
Summary: The study found that coating titanium discs with EGF improved adhesion and growth factor synthesis in keratinocytes and fibroblasts, while mitigating the negative effects of SA and ZA exposure.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Koya Nakamura, Toshiro Yamamoto, Ryo Ema, Kei Nakai, Yoshiki Sato, Kenta Yamamoto, Keiji Adachi, Fumishige Oseko, Yoshiaki Yamamoto, Narisato Kanamura
Summary: The study found that mechanical stress applied through dentures increases the production of inflammatory cytokines from oral mucosal epithelial cells and fibroblasts, likely through the p38 MAPK cascade, leading to inflammation. On the other hand, up-regulation of growth factors may be a biological defense mechanism against excessive mechanical stress.
Article
Dentistry, Oral Surgery & Medicine
Ahmed Said Rozeik, Mohamed Sad Chaar, Sandra Sindt, Sebastian Wille, Christine Selhuber-Unkel, Matthias Kern, Samar El-Kholy, Christof Doerfer, Karim M. Fawzy El-Sayed
Summary: This study investigated the viability, proliferation, and adhesion of human gingival fibroblasts (HGFs) on different implant materials in vitro. The results showed that wettability of the materials significantly affected HGF proliferation and adhesion. Within the limitations of this study, zirconia (Zr) was found to be the most biocompatible abutment material.
Review
Biochemistry & Molecular Biology
Carlos Santos-Ocana, Maria V. Cascajo, Maria Alcazar-Fabra, Carmine Staiano, Guillermo Lopez-Lluch, Gloria Brea-Calvo, Placido Navas
Summary: Primary coenzyme Q(10) deficiency is a group of mitochondrial diseases characterized by low mitochondrial levels of CoQ due to decreased endogenous biosynthesis rate, which respond to CoQ treatment mainly at the early stages. Advances in next generation sequencing have increased the discoveries of mutations in genes involved in CoQ biosynthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Alexander Ries, Astrid Slany, Christine Pirker, Johanna C. C. Mader, Doris Mejri, Thomas Mohr, Karin Schelch, Daniela Flehberger, Nadine Maach, Muhammad Hashim, Mir Alireza Hoda, Balazs Dome, Georg Krupitza, Walter Berger, Christopher Gerner, Klaus Holzmann, Michael Grusch
Summary: In this study, novel hTERT-transduced mesothelial cell and Meso-CAF models were generated and characterized, and their impact on PM cell growth was investigated.
Article
Materials Science, Multidisciplinary
Michaela Welch, Deborah A. Flusberg, Peter Hsi, Nerses J. Haroutunian, Jose A. Santos, Ernest S. Kim, Stacey Markovic, Jonathan R. Coppeta, Charles A. Lissandrello, Jenna L. Balestrini, Vishal Tandon
Summary: Autologous cellular therapies have shown great success in treating hematological cancers and have potential for various indications. However, manufacturing these therapies at a rapid pace and low cost remains challenging, especially due to the genetic modification of target cells using expensive viral vectors. This study presents a microfluidic continuous-flow electroporation device that offers high throughput processing, high performance, and potential for automation, making it suitable for large-scale clinical manufacturing.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Rheumatology
Xiang Chen, Wang Gong, Xiaoyan Shao, Tianshu Shi, Lei Zhang, Jian Dong, Yong Shi, Siyu Shen, Jianghui Qin, Qing Jiang, Baosheng Guo
Summary: This study revealed the significant increase of senescent FLSs with OA progression, impacting autophagy and SASP expression. METTL3 negatively regulated autophagy-related genes, promoting FLS senescence. Inhibiting METTL3 could attenuate FLS senescence, offering a potential therapeutic strategy for OA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Chao Liu, Min Zhang, Xinlong Yan, Yanli Ni, Yandong Gong, Cong Wang, Xiaoling Zhang, Lingfei Wan, Hui Yang, Chen Ge, Yunqiao Li, Wenxue Zou, Rui Huang, Xiaohui Li, Bing Sun, Bing Liu, Jinbo Yue, Jinming Yu
Summary: By performing single-cell RNA sequencing on human cervical tissues at different stages of malignancy, this study reveals the transcriptional tumorigenic trajectory of cervical epithelial cells in cervical squamous cell carcinoma (CESC) and identifies key factors involved in CESC initiation and progression. It also shows significant correlations between specific myeloid, lymphoid, and endothelial cell populations and CESC progression, as well as their association with patients' prognosis. Furthermore, the study demonstrates the tumor-promoting function of matrix cancer-associated fibroblasts via the NRG1-ERBB3 pathway in CESC. This research provides valuable insights for refining CESC diagnosis and designing optimal treatment strategies.
Article
Biochemistry & Molecular Biology
Madline P. Gund, Jusef Naim, Antje Lehmann, Matthias Hannig, Constanze Linsenmann, Axel Schindler, Stefan Rupf
Summary: Cold atmospheric plasma treatment improves the attachment of primary human gingival fibroblasts on titanium, leading to a more homogeneous and denser fibroblast coverage without altering the titanium's biological behavior.
Article
Biology
Dennis Guergen, Theresia Conrad, Michael Becker, Susanne Sebens, Christoph Roecken, Jens Hoffmann, Stefan Langhammer
Summary: This study provides evidence that low-dose multimodal therapy can effectively overcome drug resistance and improve prognosis in non-small cell lung cancer patients.
COMMUNICATIONS BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Filip Michalak, Sylwia Hnitecka, Marzena Dominiak, Kinga Grzech-Lesniak
Summary: Medications that inhibit bone resorption are commonly prescribed by orthopedists, hematologists, or oncologists, with dental professionals often overlooking their impact on oral health. While primarily affecting older individuals due to oncological issues or postmenopausal consequences, anyone can be at risk. Careful interviews and analysis of patient history and disease should always be conducted before taking any action with these medications.
Article
Dentistry, Oral Surgery & Medicine
Srividya Atkuru, Giridharan Muniraj, Thankiah Sudhaharan, Keng-Hwee Chiam, Graham Daniel Wright, Gopu Sriram
Summary: Ageing of oral fibroblasts impairs extracellular matrix production and organization, particularly affecting the structure of ECM fibers which may impact wound healing in the elderly. Aged oral fibroblasts exhibit slower proliferation rate and a senescence phenotype, leading to altered production and organization of ECM proteins such as collagen and fibronectin.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nicholas Tripodi, Fotios Sidiroglou, Vasso Apostolopoulos, Jack Feehan
Summary: PBM is an effective therapy that uses light to treat various conditions, including wound management. This study aimed to evaluate the changes in gene expression in human dermal fibroblasts in response to polarized PBM. The results showed 71 differentially expressed genes (DEGs), with most DEGs being downregulated and involved in mitochondrial or extracellular matrix-related processes. The analysis also revealed enriched biological processes, molecular functions, and cellular components, as well as significantly enriched pathways. The findings suggest that P-PBM treatment reduces cellular stress and has a broader effect on mitochondria than previously thought.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liguo Huang, Lit-Chein Chin, Koichi Kimura, Yasukazu Nakahata
Summary: This study found that human placental extract (HPE) has the ability to delay cellular senescence under oxidative stress conditions. By enhancing the expression of antioxidant genes and increasing the protein level of NRF2, a key molecule in the antioxidant pathway, HPE can mitigate oxidative stress-induced cellular damage.