Epidemiology of Bisphosphonate-Related Osteonecrosis of the Jaws: The Utility of a National Registry

Purpose: Little is known about the epidemiology of osteonecrosis of the jaws. To date, no population-based studies have rigorously evaluated risk factors, treatment factors, or outcomes. We aimed to perform Such a study. Materials and Methods: We reviewed the literature for epidemiologic studies on osteonecrosis of the jaws. Results: Current epidemiologic information is generally derived from anecdotal reports or case series from small institutions. Estimates that have been provided in some reports have questionable validity because of a lack of standardized case definitions, clearly defined source populations, and clear methods for obtaining (or confirming) full reporting. Population-based prospective registries are capable of answering and informing several of the outstanding questions about bisphosphonate-related osteonecrosis of the jaws/osteonecrosis of the jaws. Conclusion: A population-based registry that collects systematic information on patient characteristics, treatments, and outcomes is essential to filling the gaps in our knowledge and understanding of bisphosphonate-related osteonecrosis of the jaws. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67:71-74, 2009, Suppl 1