Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Zineb Assili, Gilles Dolivet, Julia Salleron, Claire Griffaton-Tallandier, Claire Egloff-Juras, Berengere Phulpin
Summary: This study evaluated the incidence of denosumab-related osteonecrosis of the jaw and found that the clinical extent of MRONJ was significantly less than their radiological extent. It is recommended to perform a CBCT during the diagnosis of MRONJ to explore the entire affected dental arch.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kenneth R. Holmes, R. Davis Holmes, Montgomery Martin, Nicolas Murray
Summary: Radiopaque lesions of the jaw are diverse and require a systematic approach to diagnosis. Categorizing by attenuation pattern and considering other radiologic and clinical features can help narrow down the differential diagnosis.
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sven Otto, Eva Maria Schnoedt, Selgai Haidari, Teresa Franziska Brunner, Suad Aljohani, Mohamed Mosleh, Oliver Ristow, Matthias Troeltzsch, Christoph Pautke, Michael Ehrenfeld, Riham Fliefel
Summary: This study evaluated the efficacy of minimally invasive autofluorescence-guided resection in MRONJ, showing it to be a safe and successful treatment option for all stages of the condition.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Review
Dentistry, Oral Surgery & Medicine
Pongsapak Wongratwanich, Kiichi Shimabukuro, Masaru Konishi, Toshikazu Nagasaki, Masahiko Ohtsuka, Yoshikazu Suei, Takashi Nakamoto, Rinus G. Verdonschot, Tomohiko Kanesaki, Pipop Sutthiprapaporn, Naoya Kakimoto
Summary: Diagnosis of MRONJ is challenging and mainly relies on clinical bone exposure, various imaging modalities can provide more features and information to aid in early detection, but specific imaging features of MRONJ cannot be firmly established at present.
DENTOMAXILLOFACIAL RADIOLOGY
(2021)
Article
Biology
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J. Campagna, Nicholas A. Lentini, Eric C. Sung, Samantha Chiang, Yi-Ling Lin, Frank H. Ebetino, Varghese John, Shuting Sun, Charles E. McKenna, Ichiro Nishimura
Summary: This study presents a novel method to elucidate the pathological mechanism of BRONJ and demonstrates the potential of HMDP-DNV as an effective therapy. The results show that the intra-oral application of HMDP-DNV can selectively remove legacy N-BP from the jawbone and accelerate wound healing and bone socket healing, while attenuating osteonecrosis development. Single cell RNA sequencing reveals the resolution of chronic inflammation by increasing the expression of anti-inflammatory signature genes. This research suggests that BRONJ pathology is related to N-BP levels in jawbones.
Article
Dentistry, Oral Surgery & Medicine
Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, HyeJin Lee, Hyo-Jung Lee
Summary: The presence of periodontal disease significantly increases the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients, even without tooth extraction. Therefore, patients taking bisphosphonates should actively manage and treat periodontal diseases.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Cell Biology
Sonja E. Lobo, Robert Glickman, Wagner N. da Silva, Treena L. Arinzeh, Irina Kerkis
CELL AND TISSUE RESEARCH
(2015)
Article
Dentistry, Oral Surgery & Medicine
Kenneth E. Fleisher, Sabrina Pham, Roy A. Raad, Kent P. Friedman, Munir Ghesani, King Chong Chan, Niloufar Amintavakoli, Malvin Janal, Jamie P. Levine, Robert S. Glickman
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2016)
Article
Dentistry, Oral Surgery & Medicine
John R. Zuniga, Hans Malmstroem, Robert J. Noveck, John H. Campbell, Steven Christensen, Robert S. Glickman, Boyd J. Tomasetti, Stephen E. Boesing
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2010)
Letter
Dentistry, Oral Surgery & Medicine
Kenneth E. Fleisher, Robert S. Glickman
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2011)
Article
Dentistry, Oral Surgery & Medicine
Kenneth E. Fleisher, Anu Jolly, Uma Deepthi Chippada Venkata, Robert G. Norman, Deepak Saxena, Robert S. Glickman
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2013)
Article
Dentistry, Oral Surgery & Medicine
Kenneth E. Fleisher, Roy A. Raad, Rajan Rakheja, Vikas Gupta, King Chong Chan, Kent P. Friedman, Karen A. Mourtzikos, Malvin Janal, Robert S. Glickman
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2014)
Article
Dentistry, Oral Surgery & Medicine
X. Ji, S. Pushalkar, Y. Li, R. Glickman, K. Fleisher, D. Saxena
Article
Dentistry, Oral Surgery & Medicine
Kenneth E. Fleisher, Garrett Welch, Shailesh Kottal, Ronald G. Craig, Deepak Saxena, Robert S. Glickman
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
(2010)
Article
Dentistry, Oral Surgery & Medicine
Michael D. Turner, Robert Glickman
ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA
(2009)
Article
Dentistry, Oral Surgery & Medicine
Kenneth E. Fleisher, Malvin N. Janal, Nicole Albstein, James Young, Vanessa Bikhazi, Shlomit Schwalb, Mark Wolff, Robert S. Glickman
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2019)
Meeting Abstract
Oncology
Kenneth Evan Fleisher, Franco Muggia, Robert S. Glickman
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Joseph Geiger, Abdulrahman Hesham, Yoh Sawatari, Robert Glickman
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2020)
Editorial Material
Dentistry, Oral Surgery & Medicine
R. Bruce Donoff, Mark Poznansky, David Kochman, Bruce Lieberthal, Seema Bhansali, Allison Neale, Daniel Bryant, Robert Glickman, Amr Moursi, Cecile A. Feldman, Daniel Fine, Steve Kess, Michael C. Alfano, Ari Levy, Amid Ismail, Thomas Rams, Michael Reddy, Stuart Gansky, Rai Ramneek, Laurie K. McCauley, Robert Eber, Mark Wolff, Harlan Krumholz
JOURNAL OF DENTAL EDUCATION
(2020)
Review
Health Care Sciences & Services
Sri Nitya Reddy Induri, Yunah Caroline Chun, Joonmo Christopher Chun, Kenneth E. Fleisher, Robert S. Glickman, Fangxi Xu, Efthimia Ioannidou, Xin Li, Deepak Saxena
Summary: The global dental healthcare sector has been significantly impacted by the COVID-19 pandemic, requiring healthcare professionals to enhance infection control and preventive measures while continually analyzing new data to limit transmission. Strict compliance with public health measures and adherence to guidelines and standard protocols recommended by international organizations are essential to mitigate the spread of COVID-19 in dental care settings.
Article
Dentistry, Oral Surgery & Medicine
Smruti Pushalkar, Xin Li, Zoya Kurago, Lalitha V. Rarnanathapuram, Satoko Matsumura, Kenneth E. Fleisher, Robert Glickman, Wenbo Yan, Yihong Li, Deepak Saxena
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2014)
