Review
Biochemistry & Molecular Biology
Nidhi Chawla, Hinal Shah, Kathleen Huynh, Alex Braun, Hanna Wollocko, Nilank. C. C. Shah
Summary: Clinical hypertension is a complex cardiovascular disease that affects the body's ability to maintain homeostasis. High blood pressure is classified as systolic pressure above 130-139 and diastolic pressure above 80-89, indicating stage 1 hypertension. Pregnant women with hypertension are at risk of developing pre-eclampsia, which can progress to HELLP syndrome if not controlled. Magnesium is commonly used in the treatment of clinical hypertension, pre-eclampsia, and HELLP syndrome due to its role in vascular smooth muscle and myocardial excitability. Platelet-activating factor (PAF) exacerbates hypertension by causing platelet aggregation.
Article
Obstetrics & Gynecology
Yang Liu, Xiaoping Xu, Qian Liu, Xiaolan Luo, Bin Cai, Jingyuan He, Ruiqian Liu
Summary: This article reports a case of a late-stage tubal ectopic pregnancy complicated by severe pre-eclampsia. Surgery confirmed that the reason for the pregnancy progressing to late stage may be the abnormally thickened tubal wall, and the special attachment site of the placenta reduced the risk of rupture. The detection of a crescent-shaped placenta on imaging aids in the accurate diagnosis and distinguishing between abdominal and tubal pregnancy. Women with advanced ectopic pregnancy are more likely to develop pre-eclampsia and have poorer maternal-fetal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Editorial Material
Medicine, General & Internal
Cosmin Adrian Teodoru, Corina Tudor, Maria-Emilia Cerghedean-Florea, Horatiu Dura, Ciprian Tanasescu, Mihai Dan Roman, Adrian Hasegan, Mihnea Munteanu, Carmen Popa, Mihaela Laura Vica, Horea Vladi Matei, Horia Stanca
Summary: HELLP syndrome is a rare pregnancy complication that endangers the lives of both mother and child, characterized by hypertension, liver enzyme elevation, and low platelets. This case report describes a rare occurrence of bilateral exudative retinal detachment associated with HELLP syndrome in a 38-year-old woman after delivery. Prompt treatment with systemic corticosteroids and careful blood pressure management led to a successful resolution of subretinal fluid and significant improvement in vision. The rarity of these cases emphasizes the importance of raising awareness of this pathology among ophthalmologists.
Review
Urology & Nephrology
Omar Cabarcas-Barbosa, Olivia Capalbo, Alberta Ferrero-Fernandez, Carlos G. Musso
Summary: Organ crosstalk is crucial for maintaining homeostasis and adapting to a changing environment. During pregnancy, the process of placentation and hormonal changes can impact kidney function, leading to potential kidney injury. Hypertensive disorders in pregnancy, such as pre-eclampsia and HELLP syndrome, can cause abnormal placentation and release of antiangiogenic factors, further increasing the risk of kidney damage. Conversely, pre-existing kidney injury or chronic kidney diseases can increase the likelihood of developing hypertensive pregnancy disorders. Understanding the bidirectional relationship between the placenta and the kidneys is important for minimizing organ damage and improving maternal and fetal outcomes.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Acoustics
R. J. Martinez-Portilla, L. C. Poon, L. Benitez-Quintanilla, A. Sotiriadis, M. Lopez, D. L. Lip-Sosa, F. Figueras
Summary: This systematic review aimed to investigate the risk of pre-eclampsia in pregnant women with congenital heart disease (CHD). The results showed no evidence of higher incidence of pre-eclampsia in women with CHD above the expected baseline risk, challenging the theory of cardiac origin of pre-eclampsia.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Cell Biology
Lina Bergman, Karl Bergman, Eduard Langenegger, Ashley Moodley, Stephanie Griffith-Richards, Johan Wikstrom, David Hall, Lloyd Joubert, Philip Herbst, Sonja Schell, Teelkien van Veen, Michael Belfort, Stephen Y. C. Tong, Susan Walker, Roxanne Hastie, Catherine Cluver
Summary: This project aims to establish a pre-eclampsia biobank in South Africa, focusing on phenotyping severe disease and improving understanding, prediction, and potential drug evaluation of organ complications associated with the condition.
Article
Obstetrics & Gynecology
Elleke van Der Meij, Tanneke Herklots, Suhaila Yussuf, Tarek Meguid, Arie Franx, Beth A. Payne, Benoit Jacod
Summary: The retrospective external validation of miniPIERS in a referral hospital in Zanzibar showed that the model's discriminative ability in hypertensive disorders of pregnancy was inaccurate and not likely to aid risk stratification. Limited clinical data made validation of any model challenging.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Jiangnan Pei, Zhenzhen Liu, Chengjie Wang, Nan Chu, Lei Liu, Yao Tang, Haiyan Liu, Qianqian Xiang, Haidong Cheng, Mingqing Li, Weirong Gu
Summary: SIRT1 plays a significant role in the pathogenesis of pre-eclampsia, with progesterone showing better efficacy than metformin in alleviating symptoms mediated by SIRT1 deficiency.
Article
Obstetrics & Gynecology
Kelly S. Gibson, C. Andrew Combs, Samuel Bauer, Rebecca Feldman Hamm, Andrew Healy, Jamie Morgan, Lorraine Toner, Amy Whitsel
Summary: Hypertensive disorders of pregnancy are a major cause of maternal morbidity and mortality, so it is necessary to establish corresponding follow-up metrics to improve the timely follow-up rate of patients with severe hypertension.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Cecilie Holm Christiansen, Stinne Hogh, Line Rode, Jeppe Bennekou Schroll, Hanne Kristine Hegaard, Hanne Trap Wolf
Summary: This systematic review and meta-analysis examined the association between multivitamin use and the risk of preeclampsia. The results showed very weak evidence suggesting that multivitamin use might reduce the risk of preeclampsia. However, due to limited and low-quality studies, further large-scale randomized controlled trials are needed to confirm these findings. Therefore, no final conclusions can be drawn regarding the preventive effect of multivitamin use in relation to preeclampsia based on the results of this review.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Sarka Lisonkova, Jeffrey N. Bone, Giulia M. Muraca, Neda Razaz, Li Qing Wang, Yasser Sabr, Amelie Boutin, Chantal Mayer, K. S. Joseph
Summary: This population-based study aimed to assess the gestational age-specific incidence rates and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, as well as eclampsia. The results showed different rates and risk factors for these severe pregnancy complications based on gestational age. Younger maternal age was associated with an increased risk for eclampsia and term-onset severe preeclampsia, while older mothers had elevated risks for severe preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Zhaoqi Li, Ying Dai, Lin Yun, Wei Guo
Summary: This study aimed to establish a prediction model for PE complicated with HELLP syndrome using multiple-factor logistic regression analysis. MAP, APRI, CHE, FDP, and Ca were identified as independent factors affecting PE complicated with HELLP syndrome, and a prediction model based on these factors was constructed.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ilona Jaszczuk, Izabela Winkler, Dorota Koczkodaj, Maciej Skrzypczak, Agata Filip
Summary: This review article analyzes the role of C19MC miRNA in the development of pre-eclampsia and summarizes the current research data. The results indicate that C19MC miRNAs are significantly upregulated in placental tissue of pre-eclampsia patients and can be detected in high levels in the blood. Among them, miR-525-5p shows low expression in the plasma of the first trimester. By identifying these miRNAs, it may be possible to predict the development of pre-eclampsia before the onset of clinical symptoms, thereby avoiding serious complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Cleo C. L. van Aanhold, Manon Bos, Katrina M. Mirabito Colafella, Marie-Louise P. Van Der Hoorn, Ron Wolterbeele, Jan A. Bruijn, Kitty W. M. Bloemenkamp, Anton H. van den Meiracker, A. H. Jan Danser, Hans J. Baelde
Summary: The protein levels of glomerular thrombomodulin were found to increase in women with pre-eclampsia and rats exposed to angiogenesis inhibitors, suggesting a nephroprotective mechanism to protect the glomerular filtration barrier.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Ayse Filiz Gokmen Karasu, Serdar Aydin, Seda Ates, Taha Takmaz, Cihan Comba
Summary: Hyoscine-n-butyl bromide reduced the need for pain medication compared to placebo. Larger studies are needed to further investigate the role of HBB in facilitating pre-operative cervical priming.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Obstetrics & Gynecology
Taha Takmaz, Serdar Aydin, Irana Gorchiyeva, Ayse Filiz Gokmen Karasu
Summary: The study found that using fundal pressure during the second stage of delivery is associated with a higher risk of levator ani muscle defect and loss of anterior vaginal wall support.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Urology & Nephrology
Ayse Filiz Gokmen Karasu, Serdar Aydin, Senad Kalkan, Cevper Ersoz
Summary: This study aimed to investigate the role of urodynamic measurements of flow in assessing urethral resistance on prediction of stress incontinence and ISD. The results demonstrated that Qacc is higher in ISD stress incontinent women than stress incontinent women, suggesting Qacc may provide a more reliable indication of urethral resistance and tonus.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2021)
Editorial Material
Obstetrics & Gynecology
Taha Takmaz, Serdar Aydin, Ayse Filiz Gokmen Karasu
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Serdar Aydin, Hande Nur Oncu, Dilek Sema Arici
Summary: Persistent infection with high-risk genotypes of human papillomavirus is crucial for high-grade cervical cancer precursors. Management of women with cytology negative, high-risk HPV positive is important, especially after the widespread use of HPV testing. The study showed a relatively high positive predictive value for CIN2+ in women with other high-risk HPV genotypes, other than HPV 16/18, among cytology negative population. HPV 33, 51, 58, 59, and 18 had similar positive predictive values for CIN2+ in cytology negative population.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Urology & Nephrology
Serdar Aydin, Seda Ates, Ayse Filiz Gokmen Karasu, Cagri Arioglu
Summary: The study compared the operative times and middle-term outcomes of women undergoing VALS and abdominal sacrocolpopexy, finding that VALS had shorter operation time and hospitalization duration than AS, with similar complication and failure rates between the two procedures.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2021)
Article
Obstetrics & Gynecology
Serdar Aydin, Ayse F. G. Karasu, Mustafa Marasli, Neslihan Bademler, Gurkan Kiran, Hanife R. Dural
Summary: The study included 114 women and found substantial agreement in intraobserver reliability for normal colposcopic findings and the transformation zone, with kappa values ranging from 0.51 to 0.77. Interobserver reliability was also substantial for normal colposcopic findings, acetowhite epithelium, and lugol staining, with kappa values ranging from 0.56 to 0.76. The sensitivity, specificity, PPV, and NPV of SPC for CIN2+ were calculated and showed good performance.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Mehriban Aliyeva, Serdar Aydin
Summary: This study aimed to evaluate the effects of femur, humerus, and clavicular soft tissue thickness on birth weight estimation. The findings suggest that adding soft tissue thickness measurements to fetal biometry improves the accuracy of estimating fetal weight. The best fit formula developed in this study showed a significant correlation with birth weight.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Urology & Nephrology
Hande N. Oncu, Serdar Aydin, Cagri Arioglu
Summary: This study evaluated the effect of using uterine fundal pressure during the second stage of delivery on obstetric anal sphincter injury (OASI) among primiparous women. The results showed that fundal pressure with mediolateral episiotomy did not increase the rate of OASI detected with ultrasonography.
NEUROUROLOGY AND URODYNAMICS
(2021)
Meeting Abstract
Rheumatology
W. P. Maksymowych, U. Weber, J. Chan, R. Carmona, J. Yeung, S. Aydin, J. Reis, L. Martin, A. Masetto, O. Ziouzina, D. Mosher, S. Keeling, S. Rohekar, R. Dadashova, J. Paschke, A. Carapellucci, R. G. Lambert
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Obstetrics & Gynecology
Serdar Aydin, Neslihan Bademler, Elif Asli Sarioglu Yardimci, Cagri Arioglu, Ayse Filiz Gokmen Karasu
Summary: The study found a correlation between the clitoris and female orgasm domain, where longer clitoris-urethra distance and broader space for deep clitoris structures were associated with difficulty in reaching orgasm and arousal problems.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Psychology, Clinical
Seda Ates, Serdar Aydin, Pinar Ozcan, Rabia Zehra Bakar, Caglar Cetin
Summary: This study found that women with premature ovarian insufficiency have poorer sleep quality, higher levels of insomnia and depression. However, anxiety and fatigue levels did not differ significantly between the groups. Marital status and number of children were associated with sleep quality and depression levels.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Seda Ates, Serdar Aydin, Pinar Ozcan
Summary: The aim of this study was to investigate the reproductive profiles, metabolic parameters, and cardiometabolic risk in women with adenomyosis. The study found that women with adenomyosis were more likely to have higher gravidity and more abortions, and had increased risk of hypertension, low HDL-C, and central obesity. No significant difference was found in adiposity indices between women with and without adenomyosis.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Rehabilitation
Havvanur Albayrak, Ozden Ozyemisci-Taskiran, Ecenur Atli, Serdar Aydin
Summary: This case report presents a 45-year-old woman with neurogenic bladder and bowel dysfunction who underwent a 12-week multimodal pelvic rehabilitation program. The program resulted in improvements in urinary and fecal incontinence symptoms, as well as sexual function and neuropathic pain. The findings highlight the effectiveness of pelvic rehabilitation for individuals with neurogenic bladder and bowel dysfunctions.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Review
Obstetrics & Gynecology
Mert Yasli, Sajjad Rahmani Dabbagh, Savas Tasoglu, Serdar Aydin
Summary: Three-dimensional printing, also known as additive manufacturing, allows the creation of complex structures out of a digital model. Its applications in medical field, such as orthopedics, dentistry, urology, and reconstructive surgery, have been rapidly developing. Obstetrics and Gynecology is an emerging application field for 3D printing, which can be used in preventive medicine, diagnosis, treatment, and surgical training.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)