Tumor hypoxia and genetic alterations in sporadic cancers

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic instability in the human lymphocyte exposed to hypoxia

(2009) Jae-Ho Lee et al.   CANCER GENETICS AND CYTOGENETICS

Inactivation of the Nijmegen Breakage Syndrome Gene Leads to Excess Centrosome Duplication via the ATR/BRCA1 Pathway

(2009) M. Shimada et al.   CANCER RESEARCH

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

(2009) M. E. Crosby et al.   CANCER RESEARCH

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing

(2009) James D. Webb et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation

(2009) Nico P. Dantuma et al.   DNA REPAIR

Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

(2009) Maria Galluzzo et al.   JOURNAL OF CLINICAL INVESTIGATION

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Hypoxia/Reoxygenation-Induced Mutations in Mammalian Cells Detected by the Flow Cytometry Mutation Assay and Characterized by Mutant Spectrum

(2009) Stephen B. Keysar et al.   RADIATION RESEARCH

Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

(2008) N. Chan et al.   CANCER RESEARCH

Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

(2008) A. C. Haugen et al.   CANCER RESEARCH

Base excision repair of oxidative DNA damage and association with cancer and aging

(2008) S. Maynard et al.   CARCINOGENESIS

Mechanisms of Dealing with DNA Damage-Induced Replication Problems

(2008) Magda Budzowska et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1

(2008) Alexandra Klein et al.   MOLECULAR BIOLOGY OF THE CELL

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2

(2008) H Nakamura et al.   ONCOGENE

Hypoxia Causes Downregulation of Mismatch Repair System and Genomic Instability in Stem Cells

(2008) Francisco Javier Rodríguez-Jiménez et al.   STEM CELLS