期刊
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
卷 38, 期 1, 页码 185-191出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1447-0756.2011.01666.x
关键词
blood flow; fetoplacental vascular tone; human; oxygenation; placenta; placental vasculature
资金
- Maternal and Fetal Health Research Centre, Manchester, UK
Aim: The human fetoplacental vasculature has been suggested to be a low resistance/high flow system, but the mechanisms by which this state is achieved are unclear. Methods: This study assessed the effects of intraluminal flow and local oxygenation on isolated human placental chorionic plate arteries and veins at term using pressure myography. Results: Chorionic plate arteries and veins exhibit myogenic tone. A small but significant arterial vasodilatation was observed following exposure to hypoxia; chorionic plate veins contracted to a similar hypoxic stimulus. Under physiological conditions of pressure and oxygenation, increased luminal flow induced contraction in both chorionic plate arteries and veins. [Correction added after online publication 15th November 2011: 'induced vasodilatation' has been changed to 'induced contraction'] Conclusions: Human fetoplacental vascular tone can be manipulated by local physical factors.
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