Review
Cell Biology
Chien-Chu Huang, Ya-Wen Hsueh, Chia-Wei Chang, Hsi-Chen Hsu, Tung-Chuan Yang, Wu-Chou Lin, Hsun-Ming Chang
Summary: Early pregnancy is a complex process involving cellular elements of the fetal-maternal interface, and abnormalities in trophoblast-decidual interactions can lead to miscarriage and later pregnancy disorders. Although research has been performed in various species, there is significant species variation in trophoblast differentiation and gene regulation. Recent advancements in technology have allowed a comprehensive understanding of human implantation and placentation, and the clinical utility of fetal-maternal cellular trafficking has been explored for prenatal diagnosis and prediction of pregnancy complications. Therapeutic strategies targeting placenta-enriched molecules have also been proposed for placental dysfunction and diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Caroline Charlier, Julia Dina, Francois Freymuth, Astrid Vabret, Olivier Lortholary, Denise Antona, Marc Lecuit
Summary: Research shows that measles virus can be detected in the saliva and blood of pregnant women, leading to transmission to the fetus during pregnancy, resulting in asymptomatic infection at birth. Despite severe peripartum congenital measles, asymptomatic vertical transmission of the measles virus can occur in early pregnancy.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Petra Bakovic, Maja Kesic, Maja Peric, Ivona Beceheli, Marina Horvaticek, Meekha George, Lipa Cicin-Sain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck, Jasminka Stefulj
Summary: The study reveals the presence of functional 5-HT uptake systems in feto-placental endothelial cells and fetal platelets, as well as the sensitive to various psychotropic drugs of 5-HT transport into trophoblasts. The results highlight the importance of 5-HT homeostasis at the maternal-fetal interface.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Jiangming Zhong, Jianlin Li, Graham J. Burton, Hannu Koistinen, Ka Wang Cheung, Ernest H. Y. Ng, Yuanqing Yao, William S. B. Yeung, Cheuk-Lun Lee, Philip C. N. Chiu
Summary: This review summarizes recent findings on glycosylation, glycosyltransferases, and glycan-binding receptors at the maternal-fetal interface, and their roles in regulating endometrial receptivity, placentation, and maternal-fetal immunotolerance. Understanding the functions of glycans could enhance the diagnosis and treatment of implantation failure and pregnancy complications, and potentially serve as early predictive markers and therapeutic targets.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Multidisciplinary Sciences
Valeria Garcia-Flores, Roberto Romero, Yi Xu, Kevin Theis, Marcia Arenas-Hernandez, Derek Miller, Azam Peyvandipour, Jose Galaz, Dustyn Levenson, Gaurav Bhatti, Meyer Gershater, Errile Pusod, David Kracht, Violetta Florova, Yaozhu Leng, Li Tao, Megan Faucett, Robert Para, Chaur-Dong Hsu, Gary Zhang, Adi Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez
Summary: This study presents the maternal-fetal immune responses triggered by SARS-CoV-2 infection during pregnancy and highlights the rarity of placental infection. A T-cell dominant inflammatory response is observed at the maternal-fetal interface, but the virus remains undetectable in the placenta while triggering specific immune responses in the neonatal circulation.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Lobke M. Gierman, Gabriela B. Silva, Zahra Pervaiz, Johanne J. Rakner, Siv B. Mundal, Astrid J. Thaning, Ingunn Nervik, Mattijs Elschot, Seema Mathew, Liv Cecilie V. Thomsen, Line Bjorge, Ann-Charlotte Iversen
Summary: In preeclampsia, the placental intravillous TLR3 expression is significantly increased, while no significant increase is observed in the decidua. The functionality of TLR3 was confirmed in both the decidua and placenta, but the expression levels did not correlate between the two sites.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Immunology
Ellen Menkhorst, Nandor Gabor Than, Udo Jeschke, Gabriela Barrientos, Laszlo Szereday, Gabriela Dveksler, Sandra M. Blois
Summary: Lectin-glycan interactions, particularly those mediated by the galectin family, play crucial roles in regulating processes necessary for a successful pregnancy. Galectins specifically bind to intracellular and membrane bound carbohydrate ligands, influencing angiogenesis, immune-cell adaptations, and embryogenesis. They contribute to fetal development and placental health, with implications for pathological conditions like preeclampsia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Judith Oymans, Lucien van Keulen, Guus M. Vermeulen, Paul J. Wichgers Schreur, Jeroen Kortekaas
Summary: Shuni virus (SHUV) is a neglected orthobunyavirus found in Africa with zoonotic potential, causing severe neurological diseases in animals. Research has shown that it can be transmitted to sheep through the placenta, which provides new insights into its vertical transmission and calls for further investigation into the potential risks of SHUV infection during human pregnancies.
Article
Cell Biology
S. Adams, P. A. Stapleton
Summary: The increasing accumulation of nanoparticles in the environment poses a concern for fetal development during pregnancy. The placenta, as the interface between the mother and the fetus, plays a crucial role in the translocation and cellular uptake of nanoparticles. However, the mechanisms underlying these processes are poorly understood.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Immunology
Daniel Pitz Jacobsen, Heidi Elisabeth Fjeldstad, Guro Mork Johnsen, Ingrid Knutsdotter Fosheim, Kjartan Moe, Patji Alnaes-Katjavivi, Ralf Dechend, Meryam Sugulle, Anne Cathrine Staff
Summary: Decidua basalis, the endometrium of pregnancy, plays a crucial role in maternal-fetal interface with acute atherosis being a common lesion, particularly in conditions like preeclampsia. The causal factors and effects of acute atherosis are still uncertain, potentially involving various pathways such as inflammation and arterial lesions. Further research is needed to determine if the presence of acute atherosis can identify women at higher risk for premature cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charles Megier, Gregoire Dumery, Dominique Luton
Summary: Thyroid hormones and iodine are crucial for regulating various physiological functions, such as metabolic rate, protein synthesis, and fetal development. Imbalances in thyroid and iodine metabolism can have negative effects, especially during pregnancy. The placenta, as the interface between the mother and fetus, plays a vital role in regulating thyroid and iodine metabolism. This review provides an update on the current understanding of thyroid and iodine metabolism in both normal and pathological pregnancies, highlighting their importance for maternal and fetal health.
Review
Biochemistry & Molecular Biology
Lu Zhao, Qing Chang, Zhangzhao Cong, Yalin Zhang, Zhuxi Liu, Yuhong Zhao
Summary: The incidences of adverse maternal and fetal outcomes caused by maternal diabetes are increasing. Many researchers have investigated natural treatment methods due to the problems associated with hypoglycemic drugs. Polyphenols have anti-diabetic properties and can alleviate gestational diabetes mellitus and diabetic embryopathy through various mechanisms. Diets rich in polyphenols are beneficial to pregnant women with diabetes. However, further research is needed to better understand the complex interactions between polyphenols and maternal diabetes.
Review
Biochemistry & Molecular Biology
Lu Zhao, Qing Chang, Zhangzhao Cong, Yalin Zhang, Zhuxi Liu, Yuhong Zhao
Summary: The incidences of maternal and fetal adverse outcomes caused by maternal diabetes are increasing. Polyphenols have been shown to have anti-diabetic properties and can alleviate gestational diabetes mellitus and diabetic embryopathy. However, further research is needed to fully understand the complex interactions between polyphenols and maternal diabetes.
Article
Reproductive Biology
Leslie A. Lekatz, Praveen Shukla, Stephen T. O'Rourke, Christopher S. Schauer, Megan L. Van Emon, Kasey R. Maddock-Carlin, Kimberly A. Vonnahme
Summary: This study hypothesized that isocaloric diets low in protein would decrease the sensitivity of caruncular and cotyledonary arteries. The results showed that low protein intake increased the sensitivity of cotyledonary arteries to low doses of potassium chloride, while caruncular arteries of ewes on 80% MP diet were more sensitive to bradykinin compared to ewes on 60% and 100% MP diets.
Article
Cardiac & Cardiovascular Systems
David Ziupa, Marius Menza, Susanne Koppermann, Robin Moss, Julia Beck, Gerlind Franke, Stefanie Perez Feliz, Michael Brunner, Sonja Mayer, Heiko Bugger, Gideon Koren, Manfred Zehender, Bernd A. Jung, Gunnar Seemann, Daniela Foell, Christoph Bode, Katja E. Odening
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Pediatrics
Yael S. Rosenthal, Gabriel Chodick, Zachi Grossman, Varda Shalev, Gideon Koren
JOURNAL OF PEDIATRIC SURGERY
(2019)
Article
Rheumatology
Gil Amarilyo, Gabriel Chodick, Jonathan Zalcman, Gideon Koren, Yoel Levinsky, Ido Somekh, Liora Harel
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2019)
Meeting Abstract
Biophysics
Anatoli Y. Kabakov, Karni Moshal, YiChun Lu, Karim Roder, Turan Nilufer, Weiyan Li, Kevin Murphy, Dmitry Terentyev, Gideon Koren
BIOPHYSICAL JOURNAL
(2019)
Meeting Abstract
Biophysics
Brett Baggett, Kevin Murphy, Yueming Cao, Nilufer Turan, YiChun Lu, Lorraine Schofield, Tae Yun Kim, Dmitry Terentyev, Bum Rak Choi, John Sedivy, Gideon Koren
BIOPHYSICAL JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Gideon Koren, Galia Norton, Kira Radinsky, Varda Shalev
CLINICAL DRUG INVESTIGATION
(2019)
Review
Biochemistry & Molecular Biology
Asher Ornoy, Gideon Koren
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Ho-Seok Kwak, Jung-Yeol Han, Gideon Koren, Sang-Hee Jo, Ki-Hyun Kim
APPLIED SCIENCES-BASEL
(2019)
Article
Pediatrics
G. Koren, A. Carnevale, J. Ling, J. Ozsarfati, B. Kapur, D. Bagli
JOURNAL OF PEDIATRIC UROLOGY
(2019)
Review
Pharmacology & Pharmacy
Gideon Koren, Galia Nordon, Kira Radinsky, Varda Shalev
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2019)
Article
Medicine, General & Internal
Gideon Koren, Daniel Souroujon, Ran Shaul, Allon Bloch, Ariel Leventhal, Jason Lockett, Varda Shalev
Article
Multidisciplinary Sciences
Tae Yun Kim, Paul Jeng, JungMin Hwang, Zachary Pfeiffer, Divyang Patel, Leroy L. Cooper, Konstantinos Kossidas, Jason Centracchio, Xuwen Peng, Gideon Koren, Zhilin Qu, Bum-Rak Choi
SCIENTIFIC REPORTS
(2019)
Article
Physiology
Kevin R. Murphy, Brett Baggett, Leroy L. Cooper, Yichun Lu, Jin O-Uchi, John M. Sedivy, Dmitry Terentyev, Gideon Koren
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Medicine, General & Internal
Naama Fund, Nachman Ash, Avi Porath, Varda Shalev, Gideon Koren
Article
Medicine, General & Internal
Emily Fisher, Christine Loock, Ariana Melamed, Shulamit Blank, Gideon Koren
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2019)