Article
Immunology
Yazhuo Wang, Cong Qi, Fang Feng, Xueqing Hu, Ning Zhao, Jingxia Zhao, Tingting Di, Yujiao Meng, Danyang Yang, Haoyue Zhu, Xiawei Zhang, Ping Li, Yan Wang
Summary: The purpose of this study was to explore the potential molecular mechanism of psoriasis improvement by Resveratrol (Res). The results showed that Res reduced keratinocyte proliferation and inflammatory cytokine secretion in a psoriasis-like mouse model. Res also inhibited hypoxia and glycolysis, as well as decreased macrophage infiltration. These findings provide novel insights into the therapeutic action of Res in the treatment of psoriasis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xi Chen, Xiao Wang, Zedu Cui, Qian Luo, Zihua Jiang, Yuke Huang, Jingyi Jiang, Jin Qiu, Yan Li, Keming Yu, Jing Zhuang
Summary: Activation of microglia is crucial in neovascular retinal diseases and understanding its mechanisms can provide potential therapeutic strategies. Through single-cell RNA sequencing, this study reveals that M1 microglia-derived exosomes enhance activation and proangiogenic ability of resting microglia. The communication is mediated by miRNA miR-155-5p, which promotes microglial activation and initiates inflammatory cascade.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Kei Takahashi, Shinsuke Nakamura, Wataru Otsu, Masamitsu Shimazawa, Hideaki Hara
Summary: The study indicates that PGRN deficiency activates lysosomal function in Iba-1(+) cells, leading to abnormal inflammation. This aberrant activation may contribute to the progression of CNV, and regulating these cells could be a novel therapeutic target for exudative AMD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Yang Wang, Yuelan Gao, Yuqing Huang, Yumiao Pan, Yi Yu, Yiwen Zhou, Shan-shan Wan, Yan-ning Yang
Summary: Corneal neovascularization could lead to various sight-threatening eye diseases, and miR-497 plays a crucial role in regulating angiogenesis. miR-497 is actively involved in corneal neovascularization by targeting STAT3 and regulating its expression, impacting blood vessel growth through downstream STAT3 and VEGFA expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jie Fu, Hualin Xu, Fuyun Wu, Qiang Tu, Xiao Dong, Huaqiang Xie, Zheng Cao
Summary: This study explored the effect of empagliflozin on vascular atherosclerosis and found that it can reduce plaque area and macrophage infiltration, as well as decrease the expression of inflammatory factors. Empagliflozin improves energy metabolism by activating AMPK, which may be useful in preventing cardiovascular diseases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Article
Immunology
Jianfeng Yu, Yao Shen, Jiawei Luo, Juan Jin, Pengfei Li, Peida Feng, Huaijin Guan
Summary: This study found that upadacitinib can effectively alleviate corneal inflammation and neovascularization caused by alkali burns by inhibiting the infiltration of M1 macrophages. Therefore, upadacitinib may be an effective drug for the treatment of corneal alkali burns.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Brooklyn E. Taylor, Chieh A. Lee, Thomas E. Zapadka, Amy Y. Zhou, Katherine G. Barber, Zakary R. R. Taylor, Scott J. Howell, Patricia R. Taylor
Summary: Retinal neovascularization is a common cause of vision loss in diseases such as proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This study found that Interleukin-17A (IL-17A) plays a crucial role in the onset and progression of non-proliferative diabetic retinopathy. The researchers also discovered that IL-17A enhances vascular endothelial growth factor (VEGF) production, promotes retinal endothelial cell proliferation, and enhances VEGF-dependent vascular angiogenesis, ultimately leading to retinal neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Yinxing Cui, Junhua Chen, Zhao Zhang, Houyin Shi, Weichao Sun, Qian Yi
Summary: AMPK plays a key role in regulating metabolism and inflammation in macrophages, and has significant impacts on immune-related diseases, infectious diseases, and immunotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Pengfei Zhan, Yuqing Cui, Yujuan Cao, Xun Bao, Meili Wu, Qian Yang, Jiahui Yang, Haohan Zheng, Jian Zou, Tianhua Xie, Jiping Cai, Yong Yao, Xiaolu Wang
Summary: This study demonstrates the impact of cyclooxygenase-2/prostaglandin E-2 signaling on macrophage activation and choroidal neovascularization (CNV) formation in wet age-related macular degeneration (AMD). The results suggest that targeting the PGE(2)/EP1R signaling network could be a potential therapeutic approach for CNV in wet AMD.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Xiaowei Sun, Lusheng Ma, Xiao Li, Jiao Wang, Yuanbin Li, Zijing Huang
Summary: Ferulic acid (FA) inhibits hypoxia-induced retinal angiogenesis by regulating microglia/macrophage polarization and alleviating inflammatory response, providing a potential therapeutic strategy for retinal neovascular diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Pinghui Wei, Meiqin He, Ying Wang, Guoge Han
Summary: High-fat diet accelerates choroidal neovascularization in age-related macular degeneration. This study investigates the effects of high-fat diet on retinal and retinal pigment epithelium/choroidal acylcarnitine metabolism. The results show that high-fat diet promotes weight gain, dyslipidemia, and neovascular formation, accompanied by different changes in isomerism of metabolites.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell Biology
Laszlo Sos, Eva Garabuczi, Tibor Saghy, Gabor Mocsar, Zsuzsa Szondy
Summary: It is suggested by the research that obesity may be partially attributable to impaired efferocytosis induced by increased uptake of circulating saturated fatty acids by macrophages. Palmitate inhibits the phagocytic function of macrophages, while AMP-activated protein kinase activators can relieve this inhibition.
Article
Biochemistry & Molecular Biology
Riitta Ryyti, Mari Hamalainen, Tiina Leppanen, Rainer Peltola, Eeva Moilanen
Summary: This study investigated the effects of phenolic compounds found in lingonberry on macrophage polarization in obesity models. The results showed that resveratrol, kaempferol, and proanthocyanidins can enhance anti-inflammatory M2-type activation and inhibit pro-inflammatory M1-type activation of macrophages. These findings provide further evidence for the anti-inflammatory effects of lingonberry supplementation in obesity and support the use of lingonberry and lingonberry-based products as part of a healthy diet.
Article
Agriculture, Dairy & Animal Science
Fereshteh Sadat Rezaie, Maryam Hezavehei, Mohsen Sharafi, Abdolhosein Shahverdi
Summary: The study investigated the antioxidant effects of resveratrol during rooster semen cryopreservation and evaluated the changes in AMP-activated protein kinase expression. Results showed that RSV-0.1 improved total motility, membrane integrity, and sperm mitochondria activity, while reducing apoptotic changes. Different concentrations of RSV did not affect malondialdehyde concentration, velocity, or linearity, but a dose-dependent increase in AMP-activated protein kinase expression was observed.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)