Article
Genetics & Heredity
Ghada M. A. Ajabnoor, Suhad M. Bahijri, Wafa Alrashidi, Sumia Mohammad Enani, Aliaa A. Alamoudi, Lubna Al Sheikh, Basmah Eldakhakhny
Summary: Studies suggest that there is an association between ATP-binding cassette transporter A1 (ABCA1 C69T) gene polymorphism and the risk of type 2 diabetes mellitus (T2DM) and dyslipidemia in diabetic individuals. However, contradictory findings exist. This study aimed to investigate the prevalence of ABCA1 C69T gene polymorphism in a representative sample of the Saudi population and its possible association with dyslipidemia and dysglycemia. The results showed that the T allele of ABCA1 C69T gene polymorphism was associated with dysglycemia but not dysregulation of lipid parameters.
Article
Multidisciplinary Sciences
Zhangyan Shi, Yajie Tian, Ze Zhao, Yufei Wu, Xiuxia Hu, Junlin Li, Qianliang Chen, Yan Wang, Caiyan An, Kejin Zhang
Summary: The study found a significant association between R219K and HDLC levels, with different genotypes showing significantly different HDLC levels under various genetic models. A weak and uncertain relationship was observed between R219K and TG levels. These findings suggest potential clinical applications for lipid-related disorders, while considering factors such as race, health status, BMI, and other sources of heterogeneity.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Summary: By using simulations, the authors of this study uncover the mechanism by which ATP-binding cassette transporter A1 (ABCA1) functions in extracting lipids from the outer face of the plasma membrane and facilitating the production of high density lipoprotein (HDL). Contrary to existing models, their findings suggest that ABCA1 removes lipids from the plasma membrane and forces them through its gateway and annulus into an elongated hydrophobic tunnel. This study provides important insights into the function of ABCA1 and presents a potential target for further research.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Lei Chen, Zhen-Wang Zhao, Peng-Hui Zeng, Ying-Jie Zhou, Wen-Jun Yin
Summary: The maintenance of cellular cholesterol homeostasis is crucial for normal cell function and viability. Excessive cholesterol accumulation is the molecular basis of many diseases. Peripheral cells eliminate excessive cholesterol through cholesterol efflux, which is mainly mediated by ATP-binding cassette transporter A1 (ABCA1). This article focuses on the mechanisms underlying ABCA1-mediated cholesterol efflux, providing important insights for future investigation and lipid-lowering therapy.
Review
Health Care Sciences & Services
Jing Wang, Qianqian Xiao, Luyun Wang, Yan Wang, Daowen Wang, Hu Ding
Summary: ABCA1 plays a significant role in cholesterol homeostasis and inflammation inhibition, and decreased expression of ABCA1 is associated with an increased risk of cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Amanda J. Berberich, Robert A. Hegele
Summary: We have been using DNA sequencing in our lipid clinic for more than 20 years. Dyslipidemia is usually determined biochemically. For moderate deviations in the lipid profile, the etiology is often a combination of a polygenic susceptibility component and secondary non-genetic factors. Severe dyslipidemia is more likely to have a monogenic etiology, although a specific single-gene cause is often not found. A severe phenotype can also result from a strong polygenic predisposition aggravated by secondary factors. An early age of onset, a family history of dyslipidemia or atherosclerotic cardiovascular disease may suggest a monogenic etiology. Clinical examination focuses on detecting manifestations of monogenic syndromic conditions for severe dyslipidemia. Secondary causes must be ruled out for all patients with dyslipidemia. Here we describe an experience-based practical approach to genetic testing of patients with severe deviations in low-density lipoprotein, triglycerides, high-density lipoprotein, as well as combined hyperlipidemia and dysbetalipoproteinemia.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Cheng Zhang, Xuewen Wu, Pengmin Shi, Hongyu Ma, Fei Fang, Qianlang Feng, Shuang Zhao, Ruipu Zhang, Jinyuan Huang, Xinting Xu, Weilie Xiao, Guang Cao, Xu Ji
Summary: In this study, it was found that diterpenoids from the traditional Chinese medicine Callicarpa rubella could effectively inhibit oxidized low-density lipoprotein-induced macrophage foam cell formation by promoting cholesterol efflux, suggesting their potential as drugs for the treatment of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hong Y. Choi, Senna Choi, Iulia Iatan, Isabelle Ruel, Jacques Genest
Summary: ATP-binding cassette transporter A1 (ABCA1) is a molecular defect in Tangier disease, characterized by the absence of high-density lipoprotein cholesterol (HDL-C) in the circulation and the accumulation of cholesterol in lymphoid tissues. Atherosclerosis is caused by the accumulation of cholesterol in arteries, while HDL-C levels are inversely associated with the presence of atherosclerotic cardiovascular disease (ASCVD). Strategies to increase ABCA1 expression and activity have been studied to reduce ASCVD, but no successful clinical trials have been conducted yet. This review discusses the current understanding, challenges, and future directions in ABCA1 research for developing therapies for ASCVD.
Article
Hematology
Lilli Arndt, Ileana Hernandez-Resendiz, Doreen Moos, Janine Dokas, Silvana Mueller, Franziska Jeromin, Richard Wagner, Uta Ceglarek, Iris M. Heid, Marcus Hoering, Gerhard Liebisch, Sonja C. Stadler, Ralph Burkhardt
Summary: This study demonstrates that deficiency of Trib1 promotes the formation of atherosclerotic lesions and increases plasma cholesterol and triglyceride levels in Ldlr(-/-) mice. It also suggests that Trib1 deficiency alters hepatic lipid metabolism and induces inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sheila M. M. Manemann, Suzette J. J. Bielinski, Ethan D. D. Moser, Jennifer L. L. St Sauver, Paul Y. Y. Takahashi, Veronique L. Roger, Janet E. E. Olson, Alanna M. M. Chamberlain, Alan T. T. Remaley, Paul A. A. Decker, Jill M. M. Killian, Nicholas B. B. Larson
Summary: This study found that variability in lipid levels is associated with increased risk of cardiovascular disease (CVD) in a large electronic health record-based population cohort. High variability in total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol is independently associated with an increased risk of CVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medical Laboratory Technology
Shun Zhang, Lu Li, Jie Wang, Tingting Zhang, Ting Ye, Shuai Wang, Dongming Xing, Wujun Chen
Summary: lncRNAs, as a unique group of RNA transcripts longer than 200 nucleotides, regulate the roles of ABCA1 and ABCG1 in cholesterol efflux, influencing the development of atherosclerosis.
CLINICA CHIMICA ACTA
(2021)
Review
Pharmacology & Pharmacy
Shilpi Singh, Waseem Raza, Shahnaz Parveen, Abha Meena, Suaib Luqman
Summary: miRNAs, as non-coding nucleotide sequences, play a crucial role in cancer development, with evidence suggesting that their deregulation is associated with tumorigenesis. Flavonoids are known to modulate miRNAs expression, potentially serving as chemopreventive agents by targeting miRNAs involved in cancer progression. While extensively studied in pre-clinical settings, more research is needed to explore the clinical implications of flavonoids in targeting miRNAs for cancer prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Food Science & Technology
Faezeh Malakoti, Erfan Mohammadi, Mahsa Akbari Oryani, Darioush Shanebandi, Bahman Yousefi, Azadeh Salehi, Zatollah Asemi
Summary: MiRNAs play a role in the occurrence and development of diabetic complications by interacting with mRNA to prevent translation, and polyphenols are considered safe drugs for treating diabetic complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Hannah Gardener, Qi Sun, Philippe Grandjean
Summary: This study found that pregnant U.S. women are widely exposed to PFAS in late pregnancy, with positive associations between PFAS exposure and serum-lipid concentrations. While most PFAS were not associated with birth weight, PFNA may be associated with preterm birth.
ENVIRONMENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Rosa M. Valls, Judit Companys, Lorena Calderon-Perez, Patricia Salamanca, Laura Pla-Paga, Berner Andree Sandoval-Ramirez, Antonio Bueno, Jose Puzo, Anna Crescenti, Josep M. del Bas, Antoni Caimari, Aurora Salamanca, Alberto E. Espinel, Anna Pedret, Lluis Arola, Rosa Sola
Summary: The study assessed the effect of consuming a standardized black garlic extract with SAC on cardiovascular disease risk factors in individuals with moderate hypercholesterolemia. The results showed that the consumption of ABG extract can reduce diastolic blood pressure, particularly in men. This suggests that consuming ABG may be beneficial for achieving optimal diastolic blood pressure.
Review
Biochemistry & Molecular Biology
Ignasi Mora, Lluis Arola, Antoni Caimari, Xavier Escote, Francesc Puiggros
Summary: Although human lifespan has increased, human healthspan has not kept up the same pace, especially in brain aging. Therefore, preventive health interventions have become crucial, particularly in identifying nutritional compounds that can alleviate the detrimental effects of aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Marina Colom-Pellicer, Romina M. Rodriguez, Elia Navarro-Masip, Francisca Isabel Bravo, Miquel Mulero, Lluis Arola, Gerard Aragones
Summary: The present study investigated the interaction between zeitgeber time (ZT) and grape-seed proanthocyanidin extract (GSPE) consumption on the functionality of white adipose tissue (WAT) in rats with diet-induced obesity. The results showed that the timing of GSPE consumption influenced the metabolic response of WAT in a tissue-specific manner. Understanding the impact of circadian clock on adipose metabolism and how this is regulated by polyphenols will provide new insights for the management of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Review
Food Science & Technology
Cristina Torres-Fuentes, Manuel Suarez, Gerard Aragones, Miquel Mulero, Javier Avila-Roman, Anna Arola-Arnal, Maria Josepa Salvado, Lluis Arola, Francisca Isabel Bravo, Begona Muguerza
Summary: Cardiovascular diseases (CVD) are the leading cause of deaths worldwide, and the risk factors of CVD are influenced by biological rhythms. Phenolic compounds have potential cardioprotective properties, but their effects are influenced by administration time and photoperiod.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Nutrition & Dietetics
Aleix Ribas-Latre, Kristin Eckel-Mahan
Summary: White adipose tissue is a metabolic organ that can retract and expand based on energy needs. It is made up of mature adipocytes and cells from the stromal vascular cell fraction. The circadian clock in adipose tissue plays a crucial role in maintaining the health and function of fat.
Review
Biochemistry & Molecular Biology
Elia Navarro-Masip, Alexandre Caron, Miquel Mulero, Lluis Arola, Gerard Aragones
Summary: Energy homeostasis and metabolism in mammals are influenced by seasonal changes, with variations in photoperiod patterns driving adaptations in body weight and adiposity. Humans also show distinct patterns of energy balance depending on the season, being more susceptible to weight gain during specific times of the year. Changes in body weight are mainly reflected in adipose tissue, which is highly affected by circannual rhythms. These metabolic adaptations involve molecular modifications and disruptions in the seasonal responses are associated with increased risk of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Ma Josefina Ruiz de Azua, Alvaro Cruz-Carrion, Begona Muguerza, Gerard Aragones, Anna Arola-Arnal, Maria Paz Romero, Francisca Isabel Bravo, Manuel Suarez
Summary: This study evaluated the metabolic consequences of consuming Ekstasis tomatoes from different geographical origins and in different seasons in Fischer 344 rats. The results showed that seasonal consumption of local tomatoes reduced cardiovascular risk and atherogenic coefficient. Additionally, the photoperiod significantly affected blood glucose, insulin levels, and the expression of Srep1-c, Fas1, and Acc1 in the liver.
Article
Nutrition & Dietetics
Veronica Arreaza-Gil, Javier Avila-Roman, Ivan Escobar-Martinez, Begona Muguerza, Manuel Suarez, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: Seasonal rhythms can influence gut microbiota, bioactive compounds, and inflammation. This study aimed to investigate the effects of photoperiod on the modulation of oxylipins (OXLs) in healthy and obesogenic conditions. The results showed that photoperiods affected OXLs levels influenced by gut microbiota, and the grape seed proanthocyanidin extract (GSPE) had an impact on prostaglandin E2 (PGE2) levels under certain photoperiod conditions. This is the first study to demonstrate the effects of photoperiod on OXLs metabolites.
Article
Plant Sciences
Alvaro Cruz-Carrion, Ma Josefina Ruiz de Azua, Begona Muguerza, Miquel Mulero, Francisca Isabel Bravo, Anna Arola-Arnal, Manuel Suarez
Summary: A study compared thirteen plant-based foods cultivated in organic (ORG) and non-organic (NORG) farming systems in terms of antioxidant capacity and phenolic compound content. The results showed that NORG fruits had higher phenolic compounds content, while ORG fruits had more antioxidant capacity. NORG legume stood out for having higher values from all parameters analyzed. ORG nuts had higher flavan-3-ols and flavonols content but lower antioxidant capacity compared to their NORG counterparts. ORG vegetables displayed higher phenolics and anthocyanins content, resulting in higher antioxidant capacity than NORG ones. These findings suggest that farming systems modulate phenolic compound composition and antioxidant capacity based on the plant species studied.
Article
Oncology
Lisa Christen, Helen Broghammer, Inka Rapoehn, Kevin Moehlis, Christian Strehlau, Aleix Ribas-Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Koerner, Kerstin Rohde-Zimmermann, Anne Hoffmann, Nora Kloeting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen-Cotta, Michael Stumvoll, Matthias Blueher, John T. Heiker, Juliane Weiner
Summary: This study demonstrates the functional relevance of myoglobin (MB) in brown adipose tissue (BAT), showing that MB controls mitochondrial function and thermogenesis in brown and beige adipocytes. MB not only facilitates oxygen storage and flux to the mitochondria, but also regulates the acute response of BAT to adrenergic stimulation, signaling, and lipolysis. The overexpression of MB in white adipocytes also increases their metabolic activity. These findings provide valuable insights into the mechanisms of thermogenesis in BAT and potential therapeutic approaches for obesity and related diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Physiology
Jorge R. Soliz-Rueda, Raul Lopez-Fernandez-Sobrino, Harriet Schellekens, Cristina Torres-Fuentes, Lluis Arola, Francisca Isabel Bravo, Begona Muguerza
Summary: Biological rhythms are endogenously generated natural cycles that regulate various physiological mechanisms and homeostasis in organisms, and disrupting these rhythms can increase metabolic risk. This study investigated whether consuming a sweet treat before sleeping can disrupt diurnal rhythmicity and metabolism in healthy rats. The results showed that consuming a sweet treat at the beginning of the resting period led to increased body weight gain and higher cardiometabolic risk. Additionally, the expression of central clock genes and food intake signaling genes varied depending on the timing of the snack, highlighting the disruption of hypothalamic control of energy homeostasis.
Article
Food Science & Technology
Veronica Arreaza-Gil, Ivan Escobar-Martinez, Miquel Mulero, Begona Muguerza, Manuel Suarez, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: This study evaluates the influence of different photoperiod exposures on the bioavailability of grape seed proanthocyanidins (GSPEs) extract and found that photoperiods affect its bioavailability. Moreover, photoperiods also influence the gut microbiota composition and the bioavailability of polyphenols in the body, which in turn affects the health effects of obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Elia Navarro-Masip, Marina Colom-Pellicer, Francesca Manocchio, Anna Arola-Arnal, Francisca Isabel Bravo, Begona Muguerza, Gerard Aragones
Summary: Seasonal rhythms and photoperiod can influence metabolism and adipose tissue functionality. Supplementation with grape-seed proanthocyanidins extract (GSPE) has shown potential in preventing obesity-related alterations. In this study, GSPE supplementation was found to prevent excessive body weight gain and restore serum cholesterol and non-esterified fatty acids (NEFAs) concentrations depending on the photoperiod. GSPE also helped combat obesity-induced adipocyte hypertrophy and upregulated adiponectin mRNA levels. Overall, GSPE administration reduced the impact of obesity on adipose tissue depending on the photoperiod and type of adipose depots.
Article
Biochemistry & Molecular Biology
Andreu Gual-Grau, Maria Guirro, Noemi Boque, Lluis Arola
Summary: Genetic factors and sex can influence the gut microbiota composition and obesity status of rats fed a CAF diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Veronica Arreaza-Gil, Hector Palacios-Jordan, Maria del Mar Romero, Cristina Torres-Fuentes, Miguel A. A. Rodriguez, Xavier Remesar, Jose-Antonio Fernandez-Lopez, Anna Arola-Arnal
Summary: This study aimed to investigate the influence of timing, sex, and diet on the effects of proanthocyanidins (PAs) on the metabolome. The results showed that the effects of PAs on metabolites were sex and diet-dependent, and were also modulated by the timing of consumption.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)