Article
Biochemistry & Molecular Biology
Jie Zheng, Do-Hee Kim, Xizhu Fang, Seong Hoon Kim, Soma Saeidi, Su-Jung Kim, Young-Joon Surh
Summary: The study suggests that sulforaphane may stimulate tumor progression in hepatocarcinogenesis rather than preventing it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yaqing Li, Rong Cao, Tingting Gu, Cong Cao, Tingyue Chen, Youfei Guan, Xiaoyan Zhang
Summary: This study revealed that PPAR beta/delta enhances IL-1 beta-induced COX-2 expression and PGE2 production in hMCs via the SIRT1 pathway, providing further insights into the role of PPAR beta/delta in regulating renal inflammatory responses.
Review
Immunology
Fatima Kanso, Alia Khalil, Hiba Noureddine, Yolla El-Makhour
Summary: NF kappa B-COX-PGs pathway mediates inflammation leading to chronic inflammation, requiring treatment. Anti-inflammatory drugs are effective but come with side effects, hence the need for new safer options like thiosemicarbazones derivatives.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Qing Liao, Bao Jian Li, Yang Li, Yu Xiao, Hui Zeng, Jie Mei Liu, Li Xia Yuan, Gang Liu
Summary: Studies have shown that LIPUS-mediated BMSC-derived exosomes can promote cartilage regeneration, increase chondrocyte proliferation and extracellular matrix synthesis, and suppress inflammation. The underlying mechanism may involve the inhibition of IL-1 beta-induced activation of the NF-Kappa B pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Zhonggui Gong, Wenjing Liu, Ruilong Song, Wenxuan Dong, Kanglei Zhang, Jiahui Li, Hui Zou, Jiaqiao Zhu, Yonggang Ma, Gang Liu, Zongping Liu
Summary: Cadmium (Cd) is a heavy metal pollutant that targets the kidney. Previous studies have shown that Cd-induced nephrotoxicity is caused by apoptosis and autophagy disorders. The regulatory mechanisms of NF-kappa B in Cd-induced kidney injury are still unclear. This study found that Cd promotes the activation of NF-kappa B, which mediates the survival of NRK-52E cells through promoting autophagy and inhibiting apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Wei-juan Li, Wen-ping Zhou, Xu-yong Li, Xiao-li Jiang, Yun-chao Deng, Jie Shen, Han Xie, Gang Tan, Ling Huang, Hui Zhang
Summary: This study found that LITAF protein may play a promoting role in the formation of atherosclerosis through the NF-kappa B pathway.
CURRENT MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Yan Tian, Mingfeng Zhang, Mingjie Fan, Haixia Xu, Shunquan Wu, Sailan Zou, Yangmeng Wang, Dongmei Tang, Chunyan Zhang, Weidong Han, Hua Yu, Xianghui Fu, Wendong Huang
Summary: miR-26a regulates hepatocellular carcinoma development by attenuating oncogenic signaling pathways and inflammatory response.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Napaporn Khuanphram, Sirinya Taya, Prachya Kongtawelert, Rawiwan Wongpoomchai
Summary: The combination of sesame extract and hesperidin showed enhanced chemopreventive effects compared to using hesperidin alone, by inducing cell apoptosis, suppressing cell proliferation, and modulating hepatic lipogenesis. This may provide insights for alternative treatments against hepatocellular carcinoma.
Article
Biochemistry & Molecular Biology
Jiahua Zhang, Peishuang Yao, Wenli Han, Ying Luo, Yuke Li, Yang Yang, Hui Xia, Zhihao Chen, Qi Chen, Hong Wang, Lu Yang, Huan Li, Congli Hu, Haifeng Huang, Zhe Peng, Xiaodan Tan, Miaomiao Li, Junqing Yang
Summary: The study suggests that prenatal inflammation can negatively affect offspring brain development and susceptibility to inflammatory insult. The effects include memory impairment, neuronal necrosis, increased brain inflammatory response, altered protein expressions, and decreased exploratory behaviors. However, treatment with the COX-2 inhibitor meloxicam can significantly ameliorate these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
David G. Menter, Robert S. Bresalier
Summary: Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or prevent the progression or recurrence of cancer. Aspirin has shown potential in preventing precursor lesions and cancers, although most clinical data are inferential. The biological targets of aspirin include cyclooxygenases, with newly recognized molecular and cellular interactions suggesting additional modifiable functional targets. This review focuses on pharmacological developments and innovations in biopharmacology for a better understanding of aspirin's role in cancer chemoprevention.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Environmental Sciences
Xiaoling Liu, Chunyan Yao, Yan Tang, Xiaoyan Liu, Chenggang Duan, Chunmei Wang, Fei Han, Ying Xiang, Long Wu, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Excessive exposure to manganese may lead to neuroinflammation, and it can inhibit the expression of p53 through DNA methylation, further inducing the expression of COX-2 in microglial cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Ki Hyun Kim
Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yao-Dong Song, Yan-Yan Liu, De-Jian Li, Shu-Jun Yang, Qiao-Fang Wang, Yan-Na Liu, Meng-Ke Li, Chao-Peng Mei, Hu-Ning Cui, San-Yang Chen, Chang-Ju Zhu
Summary: The study revealed that Galangin, a natural flavonol obtained from lesser galangal, has a protective effect by reducing inflammation and oxidative stress in acute pancreatitis. It may represent a promising treatment option for this condition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati
Summary: This study revealed a novel COX-2/CYP19A1 axis in the pathogenesis of MPM that can be pharmacologically targeted, with synergistic effects observed in the combination of rofecoxib and exemestane inhibitors in MPM cell proliferation, and pAKT identified as an actionable mediator in the COX-2-CYP19A1 axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Food Science & Technology
Larissa Naomi Takeda, Lucas Fornari Laurindo, Elen Landgraf Guiguer, Anupam Bishayee, Adriano Cressoni Araujo, Lara Cristina Casadei Ubeda, Ricardo de Alvares Goulart, Sandra Maria Barbalho
Summary: Guava has medicinal properties that can be used in the treatment of various diseases and contribute to reducing the risk of chronic diseases. It also has economic importance for producing countries. The by-products of guava have potential applications in the food and cosmetic industries.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Oncology
Alisha Sachdeva, Dimple Dhawan, Gaurav K. Jain, Muekerrem Betuel Yerer, Taylor E. Collignon, Devesh Tewari, Anupam Bishayee
Summary: Oral cancer is a global cause of death, and traditional treatment methods face challenges of cancer recurrence and adverse reactions to chemotherapy drugs. Natural products play a significant role in drug discovery and have potential effects against various cancers, including oral cancer. The limited bioavailability of natural products is a major obstacle to their therapeutic application. Therefore, comprehensive utilization of various formulation strategies to improve bioavailability is important. This work presents recent advancements in novel strategies for natural product delivery that significantly enhance bioavailability and reduce adverse events in the prevention and treatment of oral cancer.
Review
Chemistry, Medicinal
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu, Anupam Bishayee
Summary: Cancer is a highly significant global health concern, and current treatment options, such as surgery, chemotherapy, radiation therapy, and immune therapy, have limitations and may lead to disease recurrence. Withaferin A, a natural bioactive compound found in the Indian medicinal plant Withania somnifera, has shown promising anticancer activities by modulating the expression and activity of oncogenic proteins. This article comprehensively discusses the biosynthesis, antineoplastic activities, mode-of-action, and clinical potential of withaferin A, as well as its effect on miRNA expression, combinational use with other cytotoxic agents, formulations, and safety profiles.
Review
Pathology
Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
Summary: About one-fourth of the global population is overweight or obese, increasing the risk of insulin resistance, cardiovascular diseases, and infections. Obesity is connected to the severity of COVID-19 and can lead to metabolic disorders. Diabetes is associated with persistent viral infections and affects vaccine effectiveness. Monitoring inflammatory and energy homeostasis markers is important in preventing obesity-related diseases.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Jack T. Burcher, Lindsay K. DeLiberto, Andrea M. Allen, Kaitlyn L. Kilpatrick, Anupam Bishayee
Summary: The high incidence of oral cancer and excessive treatment cost highlight the need for new oral cancer prevention and treatment options. The value of natural agents, including plant secondary metabolites, in preventing cancer and providing a wide range of anticancer drugs has been established. This study provides a comprehensive analysis of current preclinical and clinical results on the use of phytochemicals for oral cancer prevention and treatment. Phytochemicals exert their anticancer effects by modulating various signaling pathways and show promising effects in clinical trials. However, concerns about bioavailability may limit their clinical application. Future research should focus on in-depth mechanistic studies, novel formulations of phytochemicals, adjuvant use with conventional treatment, and randomized clinical trials.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Maryam Ghanbari-Movahed, Sahar Shafiee, Jack T. Burcher, Ricardo Lagoa, Mohammad Hosein Farzaei, Anupam Bishayee
Summary: It has been found that cancer stem cells exhibit altered metabolism compared to non-CSCs, which plays a crucial role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Two natural flavonoids, apigenin and isovitexin, have been shown to enhance the efficacy of conventional chemotherapeutic drugs by sensitizing CSCs. This study aims to critically evaluate the potential of apigenin and isovitexin in targeting CSCs in different cancers as novel therapeutic agents.
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Tara Farhadi, Osman Hesami, Amin Iranpanah, Kassidy Webber, Anupam Bishayee
Summary: The tumor microenvironment (TME) plays a crucial role in cancer development and progression. The use of nanomedicine could be a promising approach to overcome barriers in tumor-targeted therapy. Nanoparticle formulations of natural compounds have shown potential in simultaneously targeting multiple dysregulated factors in TME and reducing tumor resistance mechanisms.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Leila Kooshki, Kassidy Webber, Anupam Bishayee
Summary: Tumor cells use multiple signaling mediators to escape hypoxia and promote angiogenesis and metastasis. HIF-1 plays a critical role in tumor conditions by stimulating target genes and dysregulated pathways in invasion and migration. Targeting the HIF-1 pathway and its cross-talk mediators may be a novel strategy for cancer prevention and treatment.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Food Science & Technology
Taylor E. Collignon, Kassidy Webber, Josh Piasecki, Austin S. W. Rahman, Arijit Mondal, Sandra Maria Barbalho, Anupam Bishayee
Summary: Avocado has shown anticancer properties and contains various phytochemicals that can induce cytotoxicity, reduce tumor size and volume, making it a potential option for cancer prevention and treatment. However, more research is needed before avocado-derived phytochemicals can be developed as cancer preventive agents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Siddavaram Nagini, Manikandan Palrasu, Anupam Bishayee
MEDICINAL RESEARCH REVIEWS
(2023)
Editorial Material
Oncology
Anupam Bishayee
Review
Oncology
Neeraj Choudhary, Sweta Bawari, Jack T. Burcher, Dona Sinha, Devesh Tewari, Anupam Bishayee
Summary: Lung cancer, the leading cause of cancer-related deaths worldwide, needs the development of safe and effective treatment. Phytochemicals have shown anticancer potential against lung cancer through multiple mechanisms, making them promising chemotherapeutic agents. This review critically analyzes the evidence from in vitro, in vivo, and clinical studies to establish the potential role of phytochemicals in mitigating lung cancer by modulating signaling pathways.
Article
Biochemistry & Molecular Biology
Jose Diogo E. Reis, Paulo Wender P. Gomes, Paulo R. da C. Sa, Sonia das G. S. R. Pamplona, Consuelo Yumiko Y. e Silva, Maria Fatima das G. F. da Silva, Anupam Bishayee, Milton Nascimento da Silva
Summary: This study identified new potential mass spectrometry signatures for phragmalin-type limonoids in Swietenia macrophylla leaves, providing valuable information for future drug development efforts.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)