Review
Nutrition & Dietetics
Belal N. Alshaikh, Adriana Reyes Loredo, Kamran Yusuf, Ahmed Maarouf, Tanis R. Fenton, Sarfaraz Momin
Summary: Supplementation of DHA alone may increase the risk of necrotizing enterocolitis in preterm infants, while concurrent supplementation of ARA may help reduce the incidence of this disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Respiratory System
Leonardo Terranova, Patrizia Rise, Andrea Gramegna, Christian Pinna, Carlo Agostoni, Marie-Louise Syren, Stefano Turolo, Paola Marchisio, Francesco Amati, Stefano Aliberti, Angelo Sala, Francesco Blasi
Summary: The study found that pro-inflammatory mediators derived from arachidonic acid metabolism in sputum of bronchiectasis patients were positively associated with neutrophil elastase, Pseudomonas aeruginosa identifications, and radiological gravity index. On the other hand, pro-resolution mediators derived from docosahexaenoic acid were associated with better health status, showing an inverse correlation with radiological gravity index, bacterial infections, and sputum volume production.
RESPIRATORY RESEARCH
(2022)
Editorial Material
Biochemistry & Molecular Biology
Hans O. Kalkman
Summary: Low levels of n-3 polyunsaturated fatty acids (n-3 PUFAs) and high levels of n-6 PUFAs in the blood circulation are associated with an increased risk for suicide. Clinical studies indicate that docosahexaenoic acid (DHA, a n-3 PUFA found in fish oil) displays protective effects against suicide. Activation of the transcription factor NRF2 by DHA is suggested to be the common pharmacological activity of current anti-suicidal medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Kaylee Hahn, Joseph R. Hardimon, Doug Caskey, Douglas A. Jost, Patrick J. Roady, J. Thomas Brenna, Ryan N. Dilger
Summary: The study found that the use of sodium and potassium salts of arachidonic acid was bioequivalent to triglyceride form in terms of ARA accretion in the brain and retinal tissue of young pigs. The experimental diets did not significantly affect growth performance, liver histology, or hematological outcomes compared to the control diet.
Article
Environmental Sciences
Asahel Benitez-Hernandez, Elena Palacios, Erick J. Nunez-Vazquez, Ernesto Garcia-Mendoza, Olivia Arjona, Roberto Civera-Cerecedo
Summary: Using lipid-rich marine by-products as feed can replace commercial fishmeal, resulting in improved lipid content and growth.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Nutrition & Dietetics
Annette L. West, Elizabeth A. Miles, Lihua Han, Karen A. Lillycrop, Johnathan A. Napier, Philip C. Calder, Graham C. Burdge
Summary: The study showed that transgenic Camelina sativa seed oil and fish oil are both effective in increasing the levels of eicosapentaenoic acid and docosahexaenoic acid in white blood cells. The alteration of T cell transcriptome induced by mitogens varied between the two oils, with changes related to cell proliferation and immune function. The incorporation of these fatty acids into immune cells was comparable between the two oils, suggesting potential benefits for immune function.
Review
Biology
Emilio Herrera, Henar Ortega-Senovilla
Summary: There are limitations for animals to modify fatty acid changes, including their roles in inflammatory mediators synthesis as well as gene expression regulation. LCPUFAs are susceptible to autoxidation, prevented by antioxidants and enzymes. Fetus acquires essential fatty acids and LCPUFAs from the mother, with a release of LCPUFAs from maternal adipose tissue during late pregnancy, and their uptake by maternal liver for circulation and transfer to the fetus.
Article
Pediatrics
Shaojing Wu, Chunhong Zhu, Zhen Wang, Shumei Wang, Pengfei Yuan, Tao Song, Xiaoli Hou, Zhixian Lei
Summary: Fish oil supplementation can reduce BMI, decrease serum triglyceride, and lower systolic blood pressure in overweight or obese children and adolescents, while serum cholesterol and fasting glucose may not be significantly affected.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Liyuan Ran, Jinhui Yu, Rui Ma, Qing Yao, Mingjie Wang, Yuping Bi, Zichao Yu, Yingjie Wu
Summary: Omega-3 PUFAs rich in fish oil are believed to prevent obesity by improving lipid metabolism and regulating gut microbiota. Microalgae oil, particularly Schizochytrium microalgae oil (SMO) with a high DHA proportion, is shown to have comparable weight-loss effects to commercial fish oil and a weight-loss drug. In addition, SMO has different effects on gut microbiota, increasing the abundance of beneficial bacteria and inhibiting obesity-promoting bacteria. SMO also helps restore the disturbed metabolic capability of gut microbiota caused by a high-fat diet.
Article
Nutrition & Dietetics
Matthew G. Pontifex, Anneloes Martinsen, Rasha N. M. Saleh, Glenn Harden, Chris Fox, Michael Muller, David Vauzour, Anne-Marie Minihane
Summary: Female carriers of the APOE4 gene mutation are more likely to develop Alzheimer's disease compared to their male counterparts, and menopause may contribute to this. This study found that supplementing with DHA-enriched fish oil can mitigate the detrimental effects of menopause and the APOE4 gene mutation on cognitive function.
Article
Nutrition & Dietetics
Melanie Gsoellpointner, Margarita Thanhaeuser, Fabian Eibensteiner, Robin Ristl, Bernd Jilma, Renate Fuiko, Sophia Brandstetter, Angelika Berger, Nadja Haiden
Summary: This study analyzed the intake of polyunsaturated fatty acids (PUFAs) during complementary feeding (CF) in very low birth weight (VLBW) infants and its impact on neurodevelopment. The results showed that higher intake of total PUFAs, docosahexaenoic acid (DHA), and arachidonic acid (AA) was associated with improved cognitive and motor function at 12 months of age. However, the dietary intake of AA and DHA did not meet the recommended levels, highlighting the need to increase PUFA, DHA, and AA intake during CF for better neurodevelopmental outcomes in VLBW infants.
Article
Environmental Sciences
Zhile Guo, Yuyong Hou, Zhiyong Liu, Yanbo Ma, Tong Han, Nahui Hao, Yuanjiang Yao, Chunxuan Lan, Tongling Ge, Maliheh Safavi, Weijie Wang, Lei Zhao, Fangjian Chen
Summary: This study investigated the combined effects of bicarbonate and low temperature on alkaliphilic microalgae Dunaliella salina. It found that the addition of a certain bicarbonate under low temperature could effectively enhance biomass production and accumulation of valuable compounds, such as arachidonic acid (AA) and docosahexaenoic acid (DHA).
FRONTIERS IN MARINE SCIENCE
(2022)
Review
Nutrition & Dietetics
Hans Demmelmair, Berthold Koletzko
Summary: High obesity rates around the world point to an urgent need for effective obesity prevention measures. Animal studies suggest that the effects of essential polyunsaturated fatty acids on adipogenesis may be mediated through various mechanisms. Divergent findings from human clinical trials and observational studies suggest that recommendations for humans regarding PUFA and obesity risk are not yet possible.
Article
Nutrition & Dietetics
Madelaine Eloranta Rossholt, Marianne Bratlie, Kristina Wendel, Marlen Fossan Aas, Gunnthorunn Gunnarsdottir, Drude Fugelseth, Are Hugo Pripp, Magnus Domellof, Ketil Stordal, Tom Stiris, Sissel Jennifer Moltu
Summary: Enhanced supplementation of ARA and DHA in very preterm infants may benefit somatic growth, but there were no differences in growth and body composition outcomes between the groups at 3 months corrected age. Breastfeeding and weight gain after 36 weeks postmenstrual age were strong predictors of fat mass% at 3 months corrected age.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Zejun Hu, Peng Wu, Luping Wang, Zongyu Wu, Xiao Dong Chen
Summary: This study found that A-DHA microcapsules exhibited more stable release and digestion behaviors in the gastrointestinal tract, with better resistance to gastric proteolysis, while T-DHA microcapsules showed a decrease in release due to interaction with bile salts forming micelles. Significant positive correlations were observed between the release ratio of both microcapsules and protein hydrolysis.
Article
Biochemistry & Molecular Biology
Meng-Ting Wu, Hui-Min Su, Yi Cui, Anthony Windust, Hong-Nong Chou, Ching-jang Huang
Article
Biochemistry & Molecular Biology
Chiao-Fang Teng, Wen-Chuan Hsieh, Ching-Wen Yang, Hui-Min Su, Ting-Fen Tsai, Wang-Chou Sung, Wenya Huang, Ih-Jen Su
MOLECULAR CARCINOGENESIS
(2016)
Editorial Material
Biotechnology & Applied Microbiology
Karsten H. Weylandt, Yong Q. Chen, Kyu Lim, Hui-Min Su, Achille Cittadini, Gabriella Calviello
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Biochemistry & Molecular Biology
Gou-Chun Chen, Hui-Min Su, Yu-Shun Lin, Po-Yen Tsou, Jong-Ho Chyuan, Pei-Min Chao
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2016)
Article
Nutrition & Dietetics
Ya-Yuan Chang, Hui-Min Su, Szu-Han Chen, Wen-Tsong Hsieh, Jong-Ho Chyuan, Pei-Min Chao
Article
Multidisciplinary Sciences
Man-Chin Hua, Hui-Min Su, Tsung-Chieh Yao, Ming-Ling Kuo, Ming-Wei Lai, Ming-Han Tsai, Jing-Long Huang
Article
Biochemistry & Molecular Biology
Hui-Feng Chen, Hui-Min Su
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2013)
Editorial Material
Biotechnology & Applied Microbiology
Achille Cittadini, Gabriella Calviello, Hui-Min Su, Karsten Weylandt
BIOMED RESEARCH INTERNATIONAL
(2013)
Review
Biotechnology & Applied Microbiology
Gabriella Calviello, Hui-Min Su, Karsten H. Weylandt, Elena Fasano, Simona Serini, Achille Cittadini
BIOMED RESEARCH INTERNATIONAL
(2013)
Article
Allergy
Man-Chin Hua, Hui-Min Su, Ming-Ling Kuo, Chien-Chang Chen, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Chih-Yung Chiu, Kuan-Wen Su, Li-Chen Chen, Kuo-Wei Yeh, Jing-Long Huang
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2019)
Article
Pediatrics
Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Jing-Long Huang
Summary: Abdominal obesity has a significant impact on plasma fatty acid composition in obese and overweight children. Higher proportions of palmitoleic acid and dihomo-gamma-linolenic acid, as well as increased stearoyl-coenzyme A desaturase-1(16) and delta-6 desaturase activities, are strongly correlated with metabolic risk factors in these children.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Po-Yuan Chang, Shwu-Fen Chang, Ting-Yu Chang, Hui-Min Su, Shao-Chun Lu
Summary: The study found that PA-BSA cooperates with LDL(-) to trigger the production of IL-1 beta in macrophages through the LOX-1 and Kv channel pathways.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Psychiatry
Ya-Hui Yu, Hui-Min Su, Sheng-Hsiang Lin, Po-Chang Hsiao, Yi-Ting Lin, Chih-Min Liu, Tzung-Jeng Hwang, Ming H. Hsieh, Chen-Chung Liu, Yi-Ling Chien, Chian-Jue Kuo, Hai-Gwo Hwu, Wei J. Chen
Summary: Schizophrenia patients exhibit a long-term attenuated flush response to niacin. This response is related to altered levels of membrane polyunsaturated fatty acids (PUFAs), particularly dihomo-gamma-linolenic acid, docosahexaenoic acid, and arachidonic acid (ARA). The persistence of this attenuated response suggests a long-term vulnerability to schizophrenia beyond acute exacerbation.
Article
Oncology
Li-Hsuan Huang, Hsin-Yun Chung, Hui-Min Su
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)