Article
Oncology
Tianshu Ren, Hui Jia, Qiong Wu, Yan Zhang, Qun Ma, Dong Yao, Xudong Gao, Danni Xie, Zihua Xu, Qingchun Zhao, Yingshi Zhang
Summary: This study suggests that renin-angiotensin system inhibitors (RASIs) combined with bevacizumab (Bev) have a synergistic effect in the treatment of colorectal cancer. The combination treatment improves overall survival (OS) and progression-free survival (PFS) in patients. RASIs may also be an optimal choice for the treatment of Bev-induced hypertension.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Huan-Huan Liu, Xia-Qing Li, Jin-Feng Liu, Shuang Cui, Han Liu, Bo Hu, Si-Bo Huang, Li Wang, Wah Yang, Cun-Chuan Wang, Yu Meng
Summary: Obesity is associated with an increased risk of kidney disease, potentially through local activation of the renal tubular renin-angiotensin system (RAS). Extracellular vesicles (EVs) may play a significant role in transmitting necessary information in obesity-related kidney diseases, particularly by transporting miR-6869-5p. The findings suggest that targeting miR-6869-5p in plasma Obese-EVs could be a potential therapeutic strategy for obesity-associated kidney diseases.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Abdallah S. Attia, Mohammad Hussein, Mohamed A. Aboueisha, Mahmoud Omar, Mohanad R. Youssef, Nicholas Mankowski, Michael Miller, Ruhul Munshi, Aubrey Swinford, Adam Kline, Therese Nguyen, Eman Toraih, Juan Duchesne, Emad Kandil, Tai-Heng Chen, Tai-Heng Chen, Tai-Heng Chen, Tai-Heng Chen, Tai-Heng Chen
Summary: The study shows that neurological manifestations in COVID-19 patients upon admission are associated with increased odds of adverse outcomes, including higher rates of ICU admission, mechanical ventilation, kidney injury, and mortality.
Review
Pediatrics
Ihor Yosypiv
Summary: Mutations in genes of the renin-angiotensin system can lead to congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. Understanding the underlying mechanisms of CAKUT is crucial for improving the care of affected children. Recent advances have shed light on how disruption of the renin-angiotensin system during kidney development contributes to CAKUT.
PEDIATRIC NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucile Yart, Edith Roset Bahmanyar, Marie Cohen, Begona Martinez de Tejada
Summary: Placental development and function are crucial for efficient maternal-fetal exchanges, pregnancy-specific hormone secretion, and immune modulation. Incorrect placental development can lead to serious pregnancy disorders, such as preeclampsia, endangering both the mother and the infant. The role of the uteroplacental renin-angiotensin system in placental development and function may have been underestimated.
Article
Pharmacology & Pharmacy
Nadin Hoffmann, Joerg Peters
Summary: The (pro)renin receptor (P)RR has important roles in the kidney and brain, independently of prorenin, in activating inflammatory and fibrotic responses in renal dysfunction and being linked to hypertension in the brain. By regulating pH and function of v-ATPase, (P) RR plays crucial roles in cellular homeostasis and autophagy in kidney, brain, and heart.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Victor Hugo Dantas Guimaraes, Barbhara Mota Marinho, Daisy Motta-Santos, Gabriela da Rocha Lemos Mendes, Sergio Henrique Sousa Santos
Summary: Obesity and metabolic disorders are significant global health problems, and the gut microbiota plays a crucial role in regulating systemic homeostasis. Recent evidence suggests that the microbiota and its signaling pathways can influence overall metabolism and the Renin-Angiotensin System (RAS), which, in turn, may impact the microbiota. This review aims to explore the nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome. It discusses the metabolic changes associated with obesity, diabetes, and hepatic steatosis based on relevant scientific literature, as well as the molecular and physiological mechanisms that affect the human microbiome. The review also analyzes the interaction and modulation of the RAS. Strategies such as the use of prebiotics, symbiotics, probiotics, and biotechnology may have an impact on gut microbiota and human health.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Biology
Ewa Kwiatkowska, Sebastian Kwiatkowski, Violetta Dziedziejko, Izabela Tomasiewicz, Leszek Domanski
Summary: Acute kidney injury (AKI) can occur due to reduced renal perfusion, with the kidneys being susceptible to ischemia because of the anatomical microcirculation around the renal tubules. Impaired blood flow causes damage to the endothelium and thrombosis, leading to the destruction of small vessels. This peritubular rarefaction is believed to be the main cause of irreversible changes in the damaged kidney and the development of chronic kidney disease. This article discusses the structure of renal microcirculation, its regulation, and the mechanisms of acute ischemic damage, with a focus on preventing it through the inhibition of the renin-angiotensin-aldosterone system.
Review
Medicine, General & Internal
Ke Ma, Zi-Run Zheng, Yu Meng
Summary: Chronic kidney disease (CKD) and Alzheimer's disease (AD) are common in the aging population, but the connection between them is still unclear. This review shows that the development of CKD may contribute to AD, especially through the renin-angiotensin system (RAS).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sarah M. Nwia, Ana Paula O. Leite, Xiao Chun Li, Jia Long Zhuo
Summary: Cardiovascular disease demonstrates significant biological sex differences, allowing for tailored approaches to prevention and treatment. Hypertension, a major risk factor for various diseases, affects a significant percentage of the American population. Women have lower rates of hypertension during reproductive years, but this protection diminishes after menopause. Treatment-resistant hypertension remains a challenge, suggesting unknown mechanisms in blood pressure regulation. Understanding the genetic and hormonal differences in hypertension can lead to sex-specific treatments and improved outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Smaranda Maier, Laura Barcutean, Rodica Balasa
Summary: This article reviews the role of the renin-angiotensin system in stroke neuroprotection. The effects of the renin-angiotensin system on receptors were observed, and the neuroprotective properties seem to be independent of the blood pressure reduction mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Motoko Yanagita, Hisashi Sawada, Alan Daugherty, Hong S. Lu
Summary: This study investigated the role of the renal renin-angiotensin system (RAS) in atherosclerosis development. While whole body inhibition of the RAS had significant effects, specific manipulation of RAS components in renal proximal tubule cells had no impact on atherosclerosis in either sex. These findings suggest that the site of RAS activity influencing lesion formation is still unknown.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Jorge F. Giani, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein
Summary: Renal angiotensin-converting enzyme (ACE) plays a key role in the development of various kidney diseases, particularly hypertension. Studies suggest that ACE may mediate its effects through mechanisms independent of Ang II conversion, involving other substrates.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Cedric Villain, Marie Metzger, Sophie Liabeuf, Aghiles Hamroun, Solene Laville, Nicolas Mansencal, Christian Combe, Denis Fouque, Luc Frimat, Christian Jacquelinet, Maurice Laville, Carole Ayav, Serge Briancon, Roberto Pecoits-Filho, Thierry Hannedouche, Benedicte Stengel, Ziad A. Massy
Summary: This study suggests that aging does not appear to modify the beneficial effects of RASi on major CKD outcomes or their potential adverse effects.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Cell Biology
Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong
JOURNAL OF CELLULAR PHYSIOLOGY
(2017)
Article
Pediatrics
Byung Kwan Kim, Hyung Eun Yim, Kee Hwan Yoo
PEDIATRIC NEPHROLOGY
(2017)
Letter
Medicine, General & Internal
Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae, Young Sook Hong
JOURNAL OF KOREAN MEDICAL SCIENCE
(2018)
Article
Cell Biology
Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae, Young Sook Hong
JOURNAL OF MOLECULAR HISTOLOGY
(2018)
Article
Pediatrics
Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae, Young Sook Hong
PEDIATRIC RESEARCH
(2019)
Article
Cell & Tissue Engineering
Hyung Eun Yim, Doo Sang Kim, Hyun Chul Chung, Brian Shing, Kyung Hyun Moon, Sunil K. George, Michael W. Kim, Zachary Atala, Ji Hyun Kim, In Kap Ko, James J. Yoo
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Article
Pathology
Kee Hwan Yoo, Hyung Eun Yim, Eun Soo Bae
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Ji Hyun Kim, Heejo Yang, Michael W. Kim, Kang Su Cho, Doo Sang Kim, Hyung Eun Yim, Zachary Atala, In Kap Ko, James J. Yoo
Summary: Recent advances in cell therapy have shown the potential to treat kidney diseases by delivering secretomes or conditioned medium (CM) derived from transplanted cells. In this study, the researchers analyzed the secretome profile of human placental stem cells (hPSC)-derived CM and identified five proteins that promote kidney repair. They demonstrated that delivering a recombinant protein cocktail with platelet-rich plasma (PRP) improved structural and functional recovery after acute kidney injury (AKI).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Eungu Kang, Hyung Eun Yim, Yoon Jeong Nam, Sang Hoon Jeong, Joo-Ae Kim, Ju-Han Lee, Min Hwa Son, Kee Hwan Yoo
Summary: This study found that exposure to airborne particulate matter can cause renal tubular cell injury and alter the vitamin D endocrine system and renin-angiotensin system. Vitamin D can attenuate renal tubular cell damage following exposure to particulate matter by suppressing the renin-angiotensin system and partially inhibiting the inflammatory response.
Article
Genetics & Heredity
Jiwon Jung, Joo Hoon Lee, Go Hun Seo, Changwon Keum, Hee Gyung Kang, Heeyeon Cho, Hajeong Lee, Su-Kil Park, Chung Hee Baek, Ro Han, Sang Taek Lee, Min Hyun Cho, Hyung Eun Yim, Ja wook Koo, Beom Hee Lee
Summary: The study evaluated the genetic spectrum of genetic kidney diseases (GKD) and the application of genetic diagnoses through whole exome sequencing (WES) in 172 pediatric or adult patients with various kidney diseases. WES diagnosed genetic diseases in 36.6% of patients, with varying diagnostic yields based on different types of kidney diseases and age groups. The findings demonstrated the high diagnostic utility of WES and its effective clinical application in patients across different age groups, leading to reclassification of renal phenotype and alterations in clinical management.
Article
Pediatrics
Do Young Kim, Hyung Eun Yim, Min Hwa Son, Kee Hwan Yoo
Summary: This study aimed to determine whether urine neutrophil gelatinase-associated lipocalin (uNGAL) is superior to pyuria for detecting urinary tract infection (UTI) regardless of urine specific gravity (SG) in young children. The diagnostic performance of uNGAL and pyuria was compared using sensitivity, specificity, likelihood ratios (LRs), predictive values (PVs), and area under the curves (AUCs) for different urine SG levels. The results showed that uNGAL had higher AUC values and better diagnostic performance than pyuria in detecting UTI, regardless of urine SG.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Hyung Eun Yim, Kee Hwan Yoo
Summary: Childhood obesity is on the rise globally, increasing the risk for chronic kidney disease (CKD). Strategies to combat obesity-related CKD include increasing physical activity, restricting caloric intake, and using medications for treatment.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2021)
Article
Pediatrics
Ji Hyun Moon, Kee Hwan Yoo, Hyung Eun Yim
Summary: The study compared the diagnostic accuracy of urinary NGAL with serum CRP and WBC count for predicting UTI and APN in febrile children. The results showed that uNGAL levels were significantly associated with UTI and APN, with higher predictive values and likelihood ratios compared to serum CRP and WBC count at each cutoff level, indicating that uNGAL may be more useful in identifying and assessing UTI in febrile children.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Hyung Eun Yim, Kyung Do Han, Bongseong Kim, Kee Hwan Yoo
EPIDEMIOLOGY AND HEALTH
(2020)
Article
Medicine, General & Internal
Jee Hyun Lee, Hyung Eun Yim, Kee Hwan Yoo
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)