Article
Chemistry, Applied
Lijiao Kan, Edoardo Capuano, Vincenzo Fogliano, Ruud Verkerk, Jurriaan J. Mes, Monic M. M. Tomassen, Teresa Oliviero
Summary: The study showed that tea polyphenols have inhibitory effects on alpha-glucosidase activity in both rat intestinal enzymes and human Caco-2 cells, but the specific effects varied depending on the type of tea extract and the enzyme being targeted.
Review
Cell Biology
Landon Haslem, Jennifer M. Hays, Franklin A. Hays
Summary: This article reviews the important role of p66Shc in cardiovascular pathologies by regulating pro-apoptotic ROS signals. It also discusses p66Shc's signaling and mitochondrial functions, and presents a new model of p66Shc's mitochondrial function.
Article
Environmental Sciences
Ji Wang, Huanbing Tian, Yongpeng Shi, Ying Yang, Feifei Yu, Hanwen Cao, Lan Gao, Mingxin Liu
Summary: This study investigates the impact of selective oxidation on polyethylene microplastics (LDPE-MPs) and their toxic effects on animals and cells. The results show that oxidized LDPE-MPs cause more severe intestinal damage, oxidative stress, and inflammatory response. Additionally, the oxidized microplastics are more prone to accumulate in cells and induce cell damage and mitochondrial dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nutrition & Dietetics
Hai Jia, Yunchang Zhang, Xuemeng Si, Yuhang Jin, Da Jiang, Zhaolai Dai, Zhenlong Wu
Summary: This study demonstrates that quercetin can alleviate diquat-induced cell injury in enterocytes by upregulating the protein abundance of Nrf2 and regulating GSH-related redox homeostasis.
Article
Biochemistry & Molecular Biology
Yue Guo, Lei Wang, Andrea Hanson, Pedro E. Urriola, Gerald C. Shurson, Chi Chen
Summary: Feeding pigs oxidized lipids has negative effects on growth and health, but the impact on amino acid metabolism has not been well studied. This research found that feeding oxidized corn oil to nursery pigs caused changes in amino acid homeostasis and metabolic pathways. These changes, including increased antioxidant responses, suggest that pigs are capable of adapting to the consumption of oxidized lipids by adjusting amino acid metabolism.
Article
Physiology
Sabita Pokhrel, Ravindra Gudneppanavar, Lakshminarayan Reddy Teegala, Ernest Duah, Charles K. Thodeti, Sailaja Paruchuri
Summary: Inflammation-induced leukotriene D-4 (LTD4) promotes endothelial dysfunction and macrophage phagocytosis, potentially contributing to atherosclerosis. CysLT(1)R antagonists, currently used for asthma treatment, show promise for repurposing in atherosclerosis therapy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pengxiang Gao, Luoyun Fang, Yucong Pan, Linshu Jiang
Summary: This study investigated the effect of Grape Seed Proanthocyanidin (GSP) on fat metabolism and adipocytokines in obese rats. The results showed that GSP supplementation reduced weight, abdominal fat weight, glucose, cholesterol, triglycerides, low-density lipoprotein, cyclooxygenase-2, and interleukin-6 levels in adipose tissue. Moreover, GSP addition caused adipocyte crumpling in vitro and reduced the mRNA expression of COX-2, LEP, and TNF-alpha in adipocytes. These findings provide evidence for exploring the role of GSP in the prevention and treatment of obesity and related diseases.
Article
Chemistry, Analytical
Qiaohong Lin, Ruijun Jian, Shengzhuo Wang, Yu Xia
Summary: Oxidized glycerophosphoethanolamines (oxPEs) are a subclass of bioactive lipids that play intricate roles in various physiological and pathological events. A combined strategy using radical-directed dissociation tandem mass spectrometry (RDD-MS/MS) and Paterno-Buchi derivatization coupled with tandem mass spectrometry has been developed for structural characterization of oxPEs. The RDD-MS/MS method integrated into a reversed-phase liquid chromatography-mass spectrometry workflow enables the profiling of 24 distinct oxPE molecules with unequivocal assignment of the OH sites at nM sensitivity. These findings demonstrate the potential of the developed method in analyzing biological systems where oxPEs may play important roles.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Applied
Hui Yang, Yezhi Qu, Yaran Gao, Shuyuan Sun, Ruixue Ding, Weihe Cang, Rina Wu, Junrui Wu
Summary: It is concerning that food allergies are becoming more common due to factors such as hygiene, microbiota, inappropriate complementary foods, and processed food consumption. Understanding the role of dietary components can improve the diagnosis, treatment, and prevention of food allergies.
Article
Biochemistry & Molecular Biology
Hilal Ahmad Mir, Roshia Ali, Zahoor Ahmad Wani, Firdous Ahmad Khanday
Summary: This study demonstrates the important role of vitamin C in breast cancer by binding with p66Shc to induce its phosphorylation, activate Rac1, increase ROS production, and promote apoptosis. This finding suggests that the p66Shc/Rac1 pathway could be a potential therapeutic target for breast cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Gisela Gerardi, Maria D. Rivero-Perez, Monica Cavia-Saiz, Beatriz Melero, Alicia Salinero-Zorita, Maria L. Gonzalez-SanJose, Pilar Muniz
Summary: Red wine pomace products have antimicrobial activities and may have an anti-Listeria effect. The invasion of Listeria strains in intestinal cell monolayers was found to be inhibited by WPP, with different effects depending on the strain and cell line. WPPs were able to protect the integrity of the intestinal barrier through modification of cell-cell junction protein expression.
Article
Integrative & Complementary Medicine
Tsan-Hung Chiu, Chang-Wen Ku, Tsung-Jung Ho, Kun-Ling Tsai, Wei-Ching Hsu, Yu-An Chen, Hsiu-Chung Ou, Hsiu- Chen
Summary: Atherosclerotic cardiovascular diseases are a major cause of death worldwide. Oxidized low-density lipoprotein (oxLDL) is a main component of atherosclerotic plaques. Dietary supplementation with antioxidants can prevent atherogenic diseases. Schisanhenol (SAL) has shown to attenuate oxLDL-induced apoptosis and ROS generation, but its underlying molecular mechanisms are not fully known.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Kaiwen Mu, David D. Kitts
Summary: This study aims to investigate the ability of common phenolic acids in the Western diet to generate H2O2 in cell culture media, and its correlation with cell proliferation in non-differentiated human intestinal carcinoma cells. Results showed that the different phenolic acids had a relative capacity to generate H2O2 in the media, and the rate and total amount of H2O2 generated depended on the type and concentration of phenolic acid. The H2O2 generated from phenolic acid autoxidation was involved in cell proliferation and apoptosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Hamza A. Alaswad, Amani A. Mahbub, Christine L. Le Maitre, Nicola Jordan-Mahy
Summary: Polyphenols from plant sources are potent anti-cancer agents that can work synergistically with standard chemotherapy drugs in leukemia treatment. They have multiple mechanisms of action, including reducing cell proliferation, inducing apoptosis, and inhibiting activation of transcription factors. Polyphenols also possess antioxidant, anti-inflammatory, anti-proliferative, and anti-tumor activities, and may reverse resistance to chemotherapy drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ming Yang, Yu-ting Liu, Ya-chun Han, Wei Zhang, Hao Zhang, Shikun Yang
Summary: This study aims to evaluate the regulatory mechanism between P66Shc and ferroptosis in cisplatin-induced acute kidney injury (CP-AKI). The results showed that the mitochondrial translocation of P66Shc could result in mitochondrial injury and lipid peroxide accumulation, ultimately leading to ferroptosis and aggravated CP-induced AKI.
CURRENT MEDICINAL CHEMISTRY
(2023)
Editorial Material
Nutrition & Dietetics
Roberta Masella, Francesca Cirulli
Article
Nutrition & Dietetics
Rosaria Vari, Antonio D'Amore, Annalisa Silenzi, Flavia Chiarotti, Sara Del Papa, Claudio Giovannini, Beatrice Scazzocchio, Roberta Masella
Summary: Promoting a healthy diet, particularly among young people, is the most effective measure to prevent dietary excesses and nutritional imbalance. MaestraNatura (MN) is an innovative nutritional education program aimed at promoting a healthy lifestyle in first-level secondary school students. This study evaluated the effectiveness of the MN program in improving knowledge in students. The results showed a significant improvement in knowledge in the MN group compared to the control group. Additionally, the students showed better performance in organizing weekly menu plans after completing the MN program.
Article
Nutrition & Dietetics
Maria Antonietta Ajmone-Cat, Roberta De Simone, Anna Maria Tartaglione, Antonella Di Biase, Rita Di Benedetto, Massimo D'Archivio, Rosaria Vari, Laura Ricceri, Federica Aureli, Francesca Iacoponi, Andrea Raggi, Francesco Cubadda, Susan J. Fairweather-Tait, Gemma Calamandrei, Luisa Minghetti
Summary: Research shows that sufficient selenium intake is important for brain and cognitive development during pregnancy and early life. A sub-optimal selenium diet may have negative effects on brain development and behavior, while a deficient selenium diet may lead to reduced antioxidant activity.
Review
Biochemistry & Molecular Biology
Maria Raza Tokatli, Leuconoe Grazia Sisti, Eleonora Marziali, Lorenza Nachira, Maria Francesca Rossi, Carlotta Amantea, Umberto Moscato, Walter Malorni
Summary: This article provides a broad review of the role of hormone regulation in gender medicine and gender differences across key clinical areas. The study highlights the influence of sex differences in immune response, cardiovascular diseases, neurological disorders, cancer, and COVID-19. It also emphasizes the importance of gender implications in occupational health and health policy, calling for more personalized clinical medicine and public health approaches.
Review
Clinical Neurology
Maria Francesca Rossi, Antonio Tumminello, Matteo Marconi, Maria Rosaria Gualano, Paolo Emilio Santoro, Walter Malorni, Umberto Moscato
Summary: Gender medicine is a new medical approach that studies the differences between women and men in terms of prevention, diagnosis, and the outcome of diseases. Migraines, the most common neurological illness, have a higher prevalence in women than in men. They have a significant impact on the psychophysical health and productivity of workers.
NEUROLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Massimo D'Archivio, Carmela Santangelo, Annalisa Silenzi, Beatrice Scazzocchio, Rosaria Vari, Roberta Masella
Summary: Regular consumption of extra virgin olive oil (EVOO) has been associated with beneficial health effects and reduced risk of chronic degenerative disorders. This can be attributed to the unique composition of EVOO in monounsaturated fats and phenolic compounds, which have antioxidant, anti-inflammatory, and immune-modulating activities. The gut microbiota, influenced by dietary components, plays an important role in normal physiology. Recent studies have focused on the interaction between EVOO polyphenols and the gut microbiota, considering the influence of sex and gender.
Article
Cell Biology
Daniela Peruzzu, Zaira Boussadia, Federica Fratini, Francesca Spadaro, Lucia Bertuccini, Massimo Sanchez, Maria Carollo, Paola Matarrese, Mario Falchi, Francesca Iosi, Carla Raggi, Isabella Parolini, Alessandra Care, Massimo Sargiacomo, Maria Cristina Gagliardi, Katia Fecchi
Summary: In this study, the role of cholesterol transport in the endosomal degradative-secretory system was explored using the U18666A inhibitor in a metastatic human melanoma cell line (WM266-4). The results showed that U18666A induced a shift of Cav-1 from the plasma membrane to the endolysosomal compartment, affecting the formation and release of small extracellular vesicles (sEVs). The inhibitor also altered the protein composition of sEVs and reduced their transfer capacity on target cells.
Article
Oncology
Alessandra Fragale, Emilia Stellacci, Giulia Romagnoli, Valerio Licursi, Stefania Parlato, Irene Canini, Giacomo Remedi, Maria Buoncervello, Paola Matarrese, Lucia Pedace, Barbara Ascione, Simone Pizzi, Marco Tartaglia, Stefania D'Atri, Carlo Presutti, Imerio Capone, Lucia Gabriele
Summary: BRAF(V600) mutations are commonly found in melanoma cells and support various oncogenic processes. The combination of romidepsin and IFN-a2b reduces melanoma proliferation, survival, and invasion, and overcomes resistance to vemurafenib. This combination treatment modulates genetic and immune pathways, restores immune signals, induces cell death, and enhances the immunogenic potential of resistant melanoma cells, providing a potential strategy for treating BRAFi-resistant metastatic melanoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Rosaria Vari, Annalisa Silenzi, Antonio d'Amore, Alice Catena, Roberta Masella, Beatrice Scazzocchio
Summary: MaestraNatura (MN) is an effective nutrition education program that improves nutrition knowledge among 9-10-year-old students. The MN program increased the percentage of correct responses in a questionnaire comparing to traditional nutrition education. Additionally, students showed an improved ability to organize a weekly dietary plan and bridged the gender gap.
Article
Cell Biology
Paola Matarrese, Rosa Vona, Barbara Ascione, Camilla Cittadini, Annalisa Tocci, Anna Maria Mileo
Summary: Dynamic reciprocity between cellular components of the tumor microenvironment and tumor cells occurs through the interaction of soluble signals. This study focuses on the functional response of non-small cell lung cancer cell lines treated with stromal factors that mimic the stimulus exerted in vivo on tumor cells. The results highlight the role of the autophagic machinery and the YAP pathway in the mutual crosstalk between tumor cells and the tumor microenvironment.
Article
Cell Biology
Claudia Abbruzzese, Silvia Matteoni, Paola Matarrese, Michele Signore, Barbara Ascione, Elisabetta Iessi, Aymone Gurtner, Andrea Sacconi, Lucia Ricci-Vitiani, Roberto Pallini, Andrea Pace, Veronica Villani, Andrea Polo, Susan Costantini, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi
Summary: This study reveals the mechanism of action of chlorpromazine (CPZ) in the treatment of glioblastoma (GBM), with PKM2 identified as its major target. CPZ can alter energy metabolism in GBM cells and inhibit their oncogenic properties, while having minimal effects on non-cancerous neuroepithelial cells.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)