Article
Chemistry, Applied
Jakub Cedrowski, Kajetan Dabrowa, Pawel Przybylski, Agnieszka Krogul-Sobczak, Grzegorz Litwinienko
Summary: SFN and ERN, two isothiocyanates, exhibit chemopreventive and anticancer activities by modulating cellular redox status and showing significant antioxidant effects at elevated temperatures. These effects are attributed to their ability to induce cytoprotective enzymes and participate in radical trapping during lipid oxidation.
Article
Food Science & Technology
Yi-Yuan Ke, Yuan-Tay Shyu, Sz-Jie Wu
Summary: High-pressure processing can increase the isothiocyanate content in broccoli, while improving total phenolic content and enhancing nutritional value. This method also stimulates myrosinase activity, prevents loss of heat-sensitive components, and effectively inhibits oxidases to maintain food quality. Additionally, high pressures have anti-inflammatory and antioxidant effects, making it a potential treatment strategy for healthy foods.
Article
Chemistry, Analytical
Han Li, Jiaojiao Li, Meng Wang, Weiyue Feng, Fuping Gao, Ying Han, Yijie Shi, Zhongying Du, Qing Yuan, Peng Cao, Xiayan Wang, Xueyun Gao, Kai Cao, Liang Gao
Summary: Identifying effective reversal agents to overcome multidrug resistance is crucial for improving tumor chemotherapy. In this study, a metal cluster-based probe called clusterbody was developed for flow sorting-assisted single-cell mass spectrometry analysis. The clusterbody, synthesized through biomimetic mineralization, selectively recognizes an efflux pump protein and enables high-throughput cell sorting based on fluorescence emitted by the probe. Protein abundance at the single-cell level is determined through precise signal amplification using laser ablation inductively coupled plasma mass spectrometry, allowing quantitative evaluation of reversal agent treatment. This work provides a new approach to identify reversal agents and sheds light on developing combined or synergetic tumor therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Anna Bertova, Szilvia Kontar, Zoltan Polozsanyi, Martin Simkovic, Zuzana Rosenbergova, Martin Rebros, Zdena Sulova, Albert Breier, Denisa Imrichova
Summary: This study revealed that repeated culture in SFN-containing media enhances autophagy, especially in ABCB1-negative S cells. Changes in cell sensitivity to SFN may be related to the expression of genes for cell-cycle checkpoints.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Microbiology
William L. Musick
Summary: Campylobacter species infections in immunocompromised patients can lead to serious diseases, but there is a lack of reliable data for treatment decisions and intrinsic antimicrobial resistance further limits treatment options. A recent study provides insights into this clinical dilemma through the investigation of a patient with Campylobacter coli bacteremia, including development, treatment, and molecular investigation.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Jianping Li, Ampon Sae Her, Nathaniel J. Traaseth
Summary: EmrE is a multidrug efflux pump in Escherichia coli that transports drugs as a homodimer using energy from the proton motive force. Research suggests that the two Glu14 residues in the dimer have independent pKa values and are not electrostatically coupled, supporting a transport pathway with well-defined protonation states in each monomer of the dimer. The findings also propose a model, hop-free exchange, for how exchangers with conformation-dependent pKa values reduce proton leakage, relevant to the SMR family and transporters with inverted repeat domains.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Angelique E. Boutzoukas, Lauren Komarow, Liang Chen, Blake Hanson, Souha S. Kanj, Zhengyin Liu, Soraya Salcedo Mendoza, Karen Ordonez, Minggui Wang, David L. Paterson, Scott Evans, Lizhao Ge, Abhigya Giri, Carol Hill, Keri Baum, Robert A. Bonomo, Barry Kreiswirth, Robin Patel, Cesar A. Arias, Henry F. Chambers, Vance G. Fowler, David van Duin
Summary: This study described the clinical, molecular epidemiology, and outcomes of Carbapenemase-producing Escherichia coli (CP-Ec) from several countries. The study found regional variations in CP-Ec and called for strengthened monitoring and treatment measures. Patients infected with metallo-beta-lactamase (MBL) producers had lower mortality rates.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Food Science & Technology
Mengjiao Wang, Min Chen, Rui Guo, Yangyang Ding, Haihui Zhang, Yuanqing He
Summary: This review summarizes the role of sulforaphane in improving T2DM and its potential mechanisms, especially in insulin resistance, glucose metabolism, lipid metabolism, oxidative stress, and inflammatory factors. It also emphasizes the effects of sulforaphane on T2DM complications and provides evidence for further research and development as a hypoglycemic drug.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Microbiology
Zhemin Zhang, Christopher E. Morgan, Meng Cui, Edward W. Yu
Summary: In this study, cryo-EM structures of the AcrD aminoglycoside efflux pump in the absence and presence of bound gentamicin were reported. It is suggested that this pump is capable of capturing aminoglycosides from the central cavity of the AcrD trimer. The results demonstrate that AcrD utilizes charged residues to bind and export drugs, mediating resistance to these antibiotics.
Review
Microbiology
Jerusha Stephen, Manjusha Lekshmi, Parvathi Ammini, Sanath H. Kumar, Manuel F. Varela
Summary: Infectious diseases caused by bacteria of the Vibrio genus have significant impacts on human health. The mechanisms of antimicrobial resistance in Vibrio spp. include biofilm formation and active antimicrobial efflux. Understanding these antimicrobial transport systems is important for studying Vibrio spp. pathogenesis and virulence.
Article
Medicine, Research & Experimental
Ya Zhang, Qifang Wu, Jian Liu, Zhongshan Zhang, Xiaojing Ma, Yaoyue Zhang, Jiawen Zhu, Ronald W. Thring, Mingjiang Wu, Yitian Gao, Haibin Tong
Summary: Sulforaphane extracted from high-risk diet can improve insulin resistance by increasing glucose uptake and insulin signaling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Yanran Li, Zigui Wang, Yanxin Qi, Zhaohui Tang, Xiaoyuan Li, Yubin Huang
Summary: In this study, a Pt-IV prodrug that can be activated in a spatiotemporally controllable manner inside the mitochondria of cancer cells was designed. The prodrug effectively released cisplatin upon red light exposure, leading to increased cytotoxicity and accumulation in cancer cells. This work demonstrates the potential of controllably activated and mitochondrion-targeting Pt-IV prodrugs to overcome chemotherapy drug resistance.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Daniela Claudia Maresca, Lia Conte, Benedetta Romano, Angela Ianaro, Giuseppe Ercolano
Summary: Erucin (ERU), a major isothiocyanate in rocket salads, has shown high efficacy as an anticancer agent. Recent studies have revealed that ERU has chemopreventive effects and acts as a H2S donor in human pancreatic adenocarcinoma. This study demonstrated that ERU can inhibit melanoma cell proliferation, induce apoptosis and cell cycle arrest, and inhibit migration, invasiveness, and clonogenic abilities. These effects are associated with melanogenesis impairment and mitochondrial fitness modulation.
Review
Chemistry, Multidisciplinary
Mehdi Rahmanian, Amir Seyfoori, Mohsen Ghasemi, Milad Shamsi, Ahmad Rezaei Kolahchi, Hassan Pezeshgi Modarres, Amir Sanati-Nezhad, Keivan Majidzadeh-A
Summary: The complexity and heterogeneity of the 3D tumor microenvironment pose challenges to tumor studies and treatment. Traditional tumor models are limited in simulating resistance mechanisms, while new technologies have potential for simulating the 3D tumor microenvironment and identifying mechanisms underlying multidrug resistance.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Plant Sciences
Donato Angelino, Edward B. Dosz, Jianghao Sun, Jennifer L. Hoeflinger, Maxwell L. Van Tassell, Pei Chen, James M. Harnly, Michael J. Miller, Elizabeth H. Jeffery
FRONTIERS IN PLANT SCIENCE
(2015)
Article
Agriculture, Multidisciplinary
Kang-Mo Ku, Moo Jung Kim, Elizabeth H. Jeffery, Young-Hwa Kang, John A. Juvik
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2016)
Article
Nutrition & Dietetics
Yung-Ju Chen, Matthew A. Wallig, Elizabeth H. Jeffery
JOURNAL OF NUTRITION
(2016)
Article
Pathology
Yung-Ju Chen, Matthew A. Wallig, Elizabeth H. Jeffery
TOXICOLOGIC PATHOLOGY
(2016)
Article
Food Science & Technology
Yung-Ju Chen, Angela D. Myracle, Matthew A. Wallig, Elizabeth H. Jeffery
JOURNAL OF FUNCTIONAL FOODS
(2016)
Article
Agriculture, Multidisciplinary
Talon M. Becker, Elizabeth H. Jeffery, John A. Juvik
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Nutrition & Dietetics
Xiaoji Liu, Yanling Wang, Jennifer L. Hoeflinger, Barbara P. Neme, Elizabeth H. Jeffery, Michael J. Miller
Article
Nutrition & Dietetics
Yanling Wang, Elizabeth H. Jeffery, Michael J. Miller, Matthew A. Wallig, Yuanfeng Wu
Article
Biochemistry & Molecular Biology
Jennifer L. Kaczmarek, Xiaoji Liu, Craig S. Charron, Janet A. Novotny, Elizabeth H. Jeffery, Harold E. Seifried, Sharon A. Ross, Michael J. Miller, Kelly S. Swanson, Hannah D. Holscher
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Nutrition & Dietetics
Craig S. Charron, Bryan T. Vinyard, Sharon A. Ross, Harold E. Seifried, Elizabeth H. Jeffery, Janet A. Novotny
BRITISH JOURNAL OF NUTRITION
(2018)
Article
Chemistry, Applied
Yanling Wang, Mark A. Berhow, Molly Black, Elizabeth H. Jeffery
Article
Food Science & Technology
Craig S. Charron, Janet A. Novotny, Elizabeth H. Jeffery, Matthew Kramer, Sharon A. Ross, Harold E. Seifried
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Nutrition & Dietetics
Alicia Arredondo Eve, Xiaoji Liu, Yanling Wang, Michael J. Miller, Elizabeth H. Jeffery, Zeynep Madak-Erdogan
Article
Nutrition & Dietetics
Craig S. Charron, Bryan T. Vinyard, Elizabeth H. Jeffery, Sharon A. Ross, Harold E. Seifried, Janet A. Novotny
FRONTIERS IN NUTRITION
(2020)
Proceedings Paper
Agronomy
E. H. Jeffery
XXIX INTERNATIONAL HORTICULTURAL CONGRESS ON HORTICULTURE: SUSTAINING LIVES, LIVELIHOODS AND LANDSCAPES (IHC2014): VI INTERNATIONAL SYMPOSIUM ON HUMAN HEALTH EFFECTS OF FRUITS AND VEGETABLES (FAVHEALTH 2014)
(2015)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)