Article
Pediatrics
Riham Eid, Maha Abdelsalam, Aya Ahmed Fathy, Hadil M. M. Abolenein, Eman Bakr Elmarghany, Aya Ahmed El-Hanafy, Nashwa Hamdy, Dina Salama Abd-Elmagid, Nermeen A. A. Niazy, Dina M. M. Abd-El Ghaffar
Summary: This study aims to investigate the effects of OPG gene polymorphisms and serum levels of OPG and RANKL on bone mineral density (BMD) in children with JIA. The results suggest that rs2073617 TT genotype and T allele, as well as RANKL/OPG ratio, may be determinants of decreased BMD in JIA. These findings highlight the importance of frequent monitoring of BMD and controlling disease activity in JIA children to preserve long-term bone health.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Maha Sabry, Seham Mostafa, Samaa Kamar, Laila Rashed, Suzanne Estaphan
Summary: This study found that MMP-9 is closely associated with the pathophysiology of osteoporosis and cardiovascular disease risk factors. Carvedilol and alendronate were found to mitigate osteoporosis, dyslipidemia, and inflammation by affecting MMP-9.
Article
Immunology
Giovanni Adami, Angelo Fassio, Maurizio Rossini, Camilla Benini, Riccardo Bixio, Denise Rotta, Ombretta Viapiana, Davide Gatti
Summary: The study uncovered unique bone profile in RA, including lower bone density and distinct biomarker patterns compared to controls. Association between bone biomarkers and clinical variables were revealed, and machine learning models and principal component analysis successfully differentiated RA patients based on bone biomarker profiles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Environmental Sciences
Aroon La-up, Pranee Mahasakpan, Udomsak Saengow
Summary: This study aimed to determine the prevalence of osteoporosis after 15 years of reduced cadmium exposure and investigate the association between urinary cadmium (U-Cd) and osteoporosis. The results showed that despite discontinued cadmium exposure for over a decade, the toxic effects on bone continued, especially in women. Increasing levels of U-Cd were correlated with decreasing bone mineral density, with the association between U-Cd and osteoporosis being significant at concentrations of U-Cd >= 10 mu g/g creatinine.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Calistus Wilunda, Norie Sawada, Atsushi Goto, Taiki Yamaji, Ribeka Takachi, Junko Ishihara, Nagisa Mori, Ayaka Kotemori, Motoki Iwasaki, Shoichiro Tsugane
Summary: The study found that increasing vegetable consumption was negatively associated with weight change, while increasing fruit consumption was positively associated with weight change. The influence of fruits and vegetables on weight change may depend on the characteristics of the fruits and vegetables.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Summary: This study aims to determine the association of lean mass and fat mass with bone mineral density in Thais. The results show that in men, lean mass index is positively correlated with lumbar spine and femoral neck bone density, while fat mass index is negatively correlated with femoral neck bone density. In women, both lean mass and fat mass index are positively correlated with lumbar spine and femoral neck bone density. These findings indicate a sex-specific influence of fat mass on bone density in Thais.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shereen M. Aleidi, Mysoon M. Al-Ansari, Eman A. Alnehmi, Abeer K. Malkawi, Ahmad Alodaib, Mohamed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: The study revealed distinct lipidomics profiles between LBMD and Ctrl groups, with 322 dysregulated lipid molecules identified, primarily in subclasses such as PC, TG, and PE. These findings offer insights into lipidomics alterations associated with bone remodeling and LBMD, potentially guiding the development of therapeutic targets and nutritional strategies for managing OP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mysoon M. Al-Ansari, Shereen M. Aleidi, Afshan Masood, Eman A. Alnehmi, Mai Abdel Jabar, Maha Almogren, Mohammed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: This study investigated sensitive and specific LBMD-associated protein biomarkers in patients diagnosed with ON and OP. The results identified distinctive proteomics profiles between the control, ON, and OP groups, as well as significant dysregulation in a panel of proteins common among the three groups. A comparison of proteins showed differences in their levels between ON and the control group, as well as between ON and OP. These findings provide potential protein biomarkers for further research on bone health and OP progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Emre Sahin, Cemal Orhan, Tansel Ansal Balci, Fusun Erten, Kazim Sahin
Summary: The study found that organic magnesium picolinate (MgPic) is more effective in increasing osteogenic protein levels in bone, preventing bone loss, and promoting bone formation in rats fed with a high-fat diet compared to inorganic magnesium oxide (MgO).
Article
Multidisciplinary Sciences
Akitoshi Katsumata, Kiyomi Kohinata, Yuka Esaki, Michio Kawai
Summary: This study evaluated the relationship between cross-sectional anatomical size and bone mineral density (BMD) of alveolar bone. The results showed that mandible width and cancellous bone CT value were significant explanatory variables affecting the BMD of the mandible.
Article
Neurosciences
Julia Dunn, Jaclyn Tamaroff, Anna DeDio, Sara Nguyen, Kristin Wade, Nicolette Cilenti, David R. Weber, David R. Lynch, Shana E. McCormack
Summary: FRDA patients have lower bone mineral density compared to healthy controls, with lower BMD correlating with disease severity in adults. Children with FRDA also have lower BMD. The survey revealed that screening for low BMD in FRDA patients is underutilized.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo, Binbin Li, Xue Shen, Lijie Feng, Fengyi Huang, Na Wang, Kemal Sherefa Oumer, Charkos Tesfaye Getachew, Shuman Yang
Summary: The study updated BMD T-score references using the most recent NHANES data, finding significant differences in the percentages of individuals classified as having osteoporosis and low bone mass between the updated and existing guidelines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Horticulture
Brigita Medveckiene, Jurgita Kulaitiene, Nijole Vaitkeviciene, Dovile Levickiene, Kristina Buneviciene
Summary: This study evaluated the content and composition of mineral elements in two species and two rosehip cultivars at different ripening stages. The results showed that the ripening stage and species/cultivars affected the content of mineral elements. The Rosa canina species accumulated the highest content of mineral elements.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
