Article
Geriatrics & Gerontology
Maria G. Luna, Shandell Pahlen, Robin P. Corley, Sally J. Wadsworth, Chandra A. Reynolds
Summary: Frailty is a physiological vulnerability that occurs across multiple systems during adulthood and can impact cognitive traits like processing speed. This study examined the association between frailty and processing speed before midlife, finding that higher frailty was associated with poorer performance, especially with increasing age.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Giulia Gregori, Alessandra Celli, Yoann Barnouin, Arjun Paudyal, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls, Dennis T. Villareal
Summary: The study indicates that testosterone replacement therapy combined with lifestyle intervention can significantly improve cognitive function in older men with obesity and hypogonadism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Clinical Neurology
Marco Canevelli, Lindsay M. K. Wallace, Giuseppe Bruno, Matteo Cesari, Kenneth Rockwood, David D. Ward
Summary: Frailty is associated with cognitive expression of neuropsychological deficits in older adults, as found in the analysis of data from three large cohort studies. Among participants with higher frailty levels, there was a stronger negative association between neuropsychological deficits and cognitive performance.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Julie D. Henry, Sarah P. Coundouris, Jessica Mead, Brielle Thompson, Ruth E. Hubbard, Sarah A. Grainger
Summary: This study examines the relationship between social cognitive difficulties and social frailty, as well as the correlation between social frailty and psychological well-being. The findings show that social cognitive difficulties and social behavior can predict increased social frailty, with social behavior being the only significant predictor. Furthermore, social frailty is also associated with various aspects of psychological well-being, with significant effects on demoralization, resilience, and life satisfaction even after adjusting for covariates.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Immunology
Carrie D. Johnston, Eugenia L. Siegler, Michelle C. Rice, Heather M. Derry-Vick, Katie C. Hootman, Yuan-Shan Zhu, Chelsie O. Burchett, Mary E. Choi, Marshall J. Glesby
Summary: This study evaluated the potential of plasma cfmtDNA as a biomarker for geriatric syndromes. The results showed that plasma cfmtDNA levels were associated with cognitive impairment and frailty in older individuals.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2022)
Review
Geriatrics & Gerontology
Paulo Giusti Rossi, Bianca Ferdin Carnavale, Ana Claudia Silva Farche, Juliana Hotta Ansai, Larissa Pires de Andrade, Anielle Cristhine de Medeiros Takahashi
Summary: This study analyzed the effects of physical exercise on the cognition of community-dwelling older adults with frailty syndrome through six randomized clinical trials. The data from the meta analysis showed that physical exercise can improve both global cognition and mental flexibility in this population. The interventions with physical exercise were found to promote benefits in cognitive function for older adults with frailty syndrome.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Geriatrics & Gerontology
Nadia M. Chu, Karen Bandeen-Roche, Qian-Li Xue, Michelle C. Carlson, A. Richey Sharrett, Alden L. Gross
Summary: Frailty (PFP) and its criteria are associated with cognitive function in older adults, with frailty showing excess effects on cognitive performance beyond criteria contributions. Different criteria have varying effects on cognitive change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Satoshi Kurita, Hideaki Ishii, Hiroyuki Shimada
Summary: This study developed a questionnaire-based Active Mobility Index (AMI) to assess going-out behavior with physical and social activity among older adults. The findings showed that lower AMI scores were associated with more depressive symptoms, frailty, cognitive impairment, and a higher risk of incident disability.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Cell Biology
Rafaella Silva dos Santos Aguiar Goncalves, Alvaro Campos Cavalcanti Maciel, Yves Rolland, Bruno Vellas, Philipe de Souto Barreto
Summary: Cellular and molecular aging biomarkers can help identify individuals at risk of frailty, but current research is limited and further investigation is needed.
AGEING RESEARCH REVIEWS
(2022)
Article
Geriatrics & Gerontology
H. D. Heisey, M. E. Kunik, C. Qualls, M. B. Segoviano-Escobar, D. T. Villareal
Summary: This study explores the associations among cognition, frailty, and obesity in older adults. The findings suggest that cognition may worsen in community-dwelling older adults with obesity, particularly with greater truncal fat mass. Frailty appears to be an important predictor of cognitive performance in this population.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Medicine, General & Internal
R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster, I. Aprahamian
Summary: The frailty index (FI) independently predicted mortality, with the highest impact in individuals with endocrine, lung, or heart diseases. Both multimorbidity and specific chronic disease clusters were associated with an accelerated increase in frailty over time, highlighting the importance of initiating frailty prevention in middle age.
Article
Geriatrics & Gerontology
Fereshteh Moradoghli, Ali Darvishpoor Kakhki, Roghayeh Esmaeili
Summary: Frailty is associated with decreased dignity in older adults, with frailty being the leading predictor of dignity. Providers should develop programs to prevent and reduce frailty in those at risk and enhance the dignity of already frail individuals.
Review
Medicine, Research & Experimental
Maria-Jose Fernandez-Cotarelo, Jasmine Y. Jackson-Akers, Stephanie E. Nagy-Agren, Cirle A. Warren
Summary: This review provides an update on the understanding of Clostridioides difficile infection (CDI), with a focus on cognitive impairment and frailty as both risk factors and consequences of CDI.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Prakriti Shrestha, Sarah E. Van Pilsum Rasmussen, Elizabeth A. King, Elisa J. Gordon, Ruth R. Faden, Dorry L. Segev, Casey Jo Humbyrd, Mara McAdams-DeMarco
Summary: Frail and cognitively impaired patients are important considerations in kidney transplant evaluation, and ethical guidelines should be developed to ensure fairness and utility.
Article
Geriatrics & Gerontology
Lixing Zhou, Hui Shi, Rui Cheng, Meiling Ge, Fengjuan Hu, Lisha Hou, Xin Xia, Xiaolei Liu, Yixin Liu, Yunli Zhao, Linghui Deng, Wanyu Zhao, Zhiliang Zuo, Xuelian Sun, Jirong Yue, Birong Dong
Summary: This study identified a potential association between pTau and frailty in older adults. Further research should monitor the longitudinal trajectory of pTau changes in frail individuals and investigate the molecular mechanisms involved.
Article
Neurosciences
Luciana Mascarenhas Fonseca, Guilherme Prado Mattar, Glenda Guerra Haddad, Ekaterina Burduli, Sterling M. McPherson, Laura Maria de Figueiredo Ferreira Guilhoto, Monica Sanches Yassuda, Geraldo Filho Busatto, Cassio Machado de Campos Bottino, Marcelo Queiroz Hoexter, Naomi Sage Chaytor
Summary: Research investigated neuropsychiatric symptoms (NPS) and caregiver distress in adults with Down syndrome (DS), finding that NPS are common and severe in DS and AD patients, contributing to caregiver distress. Symptoms of apathy, nighttime behavior disturbances, and appetite abnormalities had the greatest impact on caregiver distress.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Letter
Psychiatry
Ricardo Nitrini, Paulo Caramelli, Sonia Maria Dozzi Brucki, Monica Sanches Yassuda
BRAZILIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Tulia Fernanda Meira Garcia, Catherine Nicol de Aravena Vallero, Daniela de Assumpcao, Ivan Aprahamian, Yassuda Monica Sanches, Flavia Silva Arbex Borim, Anita Liberalesso Neri
Summary: The study found that individuals with a higher number of ideas in their spontaneous speech at baseline had a lower chance of cognitive impairment and frailty nine years later. The number of words in speech did not show a significant impact on the development of cognitive impairment and frailty, suggesting that the number of ideas in spontaneous speech may serve as a predictor for mental and physical health outcomes in older individuals after a nine-year period.
AGING & MENTAL HEALTH
(2022)
Article
Medicine, General & Internal
Giselle Layse Andrade BuarqueI, Flavia Silva Arbex Borim, Anita Liberalesso Neri, Monica Sanches Yassuda, Ruth Caldeira de Melo
Summary: Dyspnea is a common symptom among older adults with chronic diseases. It is associated with different diseases, multimorbidities, polypharmacy, and frailty.
SAO PAULO MEDICAL JOURNAL
(2022)
Review
Education & Educational Research
Karina de Lima Flauzino, Henrique Manuel Pires Teixeira Gil, Samila Sathler Tavares Batistoni, Maraiza Oliveira Costa, Meire Cachioni
Summary: The lifelong learning paradigm has become a global phenomenon and has influenced the political organization of various countries. This study examined lifelong learning activities for older people and found an imbalance among formal, non-formal, and informal educational activities.
EDUCATIONAL GERONTOLOGY
(2022)
Article
Education & Educational Research
Jussara Soares Marques dos Anjos, Lucy Gomes, Meire Cachioni, Henrique Salmazo da Silva
Summary: The aim of this study was to investigate the impacts of an environmental education program on attitudes about old age among adolescents and older adults, and to explore the associations with age group, economic class, residing with grandparents, and grandparents' contribution to parenting.
EDUCATIONAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Ligiana. P. Corona, Flavia. C. D. Andrade, Flavia. S. A. Borim, Ivan Aprahamian, Andre Fattori, Matteo Cesari, Anita L. Neri, Monica S. Yassuda
Summary: This study aims to evaluate the relationship between weight loss severity and functional decline in instrumental activities of daily living (IADL) among Brazilian oldest-old adults. The findings suggest that severe weight loss is associated with functional decline.
CLINICAL NUTRITION ESPEN
(2023)
Article
Clinical Neurology
L. L. de Godoy, A. Studart-Neto, D. R. de Paula, N. Green, A. Halder, P. Arantes, K. T. Chaim, N. C. Moraes, M. S. Yassuda, R. Nitrini, M. Dresler, C. da Costa Leite, J. Panovska-Griffiths, A. Soddu, S. Bisdas
Summary: This study aimed to investigate the key differences in discriminative networks and their main nodes between superagers and cognitively average elderly controls. The key networks that differentiated superagers and elderly controls were the default mode, salience, and language networks. Potential imaging biomarkers for predicting superagers can be provided by the functional connectivity in these networks. The 7T field holds promise for accurately detecting the functional connectivity patterns in superagers.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Viviane Amaral-Carvalho, Thais Bento Lima-Silva, Luciano Inacio Mariano, Leonardo Cruz de Souza, Henrique Cerqueira Guimaraes, Valeria Santoro Bahia, Ricardo Nitrini, Maira Tonidandel Barbosa, Monica Sanches Yassuda, Paulo Caramelli
Summary: The study investigates the value of using ACE-R combined with sociodemographic factors in the differential diagnosis between AD and bvFTD. The results show that combining ACE-R scores with age, sex, and education level can effectively differentiate AD from bvFTD.
CURRENT ALZHEIMER RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Diego Salvador Muniz da Silva, Marcela Fernandes Silva, Daniela de Assumpcao, Priscila Maria Stolses Bergamo Francisco, Anita Liberalesso Neri, Monica Sanches Yassuda, Flavia Silva Arbex Borim
Summary: The study assessed the impact of multimorbidity and its effects on the day-to-day activities of community-dwelling elderly individuals. Data from the FIBRA Study were used, and activities of daily living (ADL) were evaluated using Katz's index. Different patterns of chronic diseases were classified, including multimorbidity, cardio-pulmonary, vascular-metabolic, and mental-musculoskeletal. Analysis using chi-square test and Poisson regression revealed that elderly individuals with multimorbidity and specific disease patterns had a higher risk of functional decline in ADL over a nine-year period.
CIENCIA & SAUDE COLETIVA
(2023)
Article
Medicine, General & Internal
Flavia Silva Arbex Borim, Daniela de Assumpcao, Monica Sanches Yassuda, Henrique Trajano de Moraes Costa, Samila Sathler Tavares Batistoni, Anita Liberalesso Neri, Richard C. Oude Voshaar, Ivan Aprahamian
Summary: This study examined the direct and indirect effects of chronic pain, depressive symptoms, frailty components, and functional disability in older adults living in the community through a pathway analysis. The results showed that there was a direct association between chronic pain and depressive symptoms, and both were associated with frailty. The number of frailty components and depressive symptoms were directly associated with functional disability. Frailty had an indirect effect on the association between chronic pain, depressive symptoms, and functional disability.
EINSTEIN-SAO PAULO
(2023)
Proceedings Paper
Computer Science, Information Systems
Bruno S. Araujo, Joao Victor F. Araujo, Marcelo Fantinato, Meire Cachioni, Otavio H. Riga, Otavio P. Albuquerque, Pedro Augusto S. Giorgi, Ruth C. Melo, Samila S. T. Batistoni, Sarajane M. Peres, Patrick C. K. Hung
Summary: An exploratory study on the perception of social robots among older people in Brazil, where technological access is limited, showed that most participants were receptive to the idea of having a social robot assist them in activities or even act as a companion occasionally. However, the limitation of the robot not being able to communicate in Portuguese was noted.
2022 IEEE GAMES, ENTERTAINMENT, MEDIA CONFERENCE (GEM)
(2022)
Review
Information Science & Library Science
Bruno Sanchez de Araujo, Marcelo Fantinato, Sarajane Marques Peres, Ruth Caldeira de Melo, Samila Sathler Tavares Batistoni, Meire Cachioni, Patrick C. K. Hung
Summary: Despite the potential for using social robots in mental health interventions, in the scenario of smart cities, this review showed that their usefulness and effects in improving depressive symptoms in older adults have low internal and external validity. Future studies should consider factors such as planning the intervention based on well-established supported therapies, characteristics and needs of the subjects, and the context in which the subjects are inserted.
