Article
Health Care Sciences & Services
Carlos Marquez, Barbara Angel, Lydia Lera, Rebecca Bendayan, Hugo Sanchez, Cecilia Albala
Summary: This longitudinal study explored the association between vitamin D levels and cognitive performance in older Chilean people and found that low vitamin D levels were a risk factor for mild cognitive impairment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Sujuan Li, Xuelei Xu, Yan Qiu, Ziwei Teng, Jieyu Liu, Hui Yuan, Jindong Chen, Yuxi Tan, Min Yang, Kun Jin, Baoyan Xu, Hui Tang, Ziru Zhao, Bolun Wang, Hui Xiang, Haishan Wu
Summary: This study found that patients with bipolar disorder have higher levels of vitamin D in their serum and these levels are negatively associated with cognitive impairment. For patients with bipolar disorder, more physical activity is less beneficial to cognition than longer resting.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Geriatrics & Gerontology
Mary Waterhouse, Emma Sanguineti, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Bruce K. Armstrong, Peter R. Ebeling, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Hai Pham, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study found that monthly high-dose vitamin D supplementation did not reduce the risk of falls, and may potentially increase the risk of falling in individuals with normal BMI. Further investigation is needed to better understand the impact of vitamin D supplementation on falls risk in different populations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Nutrition & Dietetics
Zsolt Gall, Orsolya Szekely
Summary: The review highlights the importance of the neuronal effects of 1,25(OH)2D in cognitive development and maintenance, as well as the association between vitamin D deficiency and neurological disorders. It also discusses the expression of vitamin D receptors in the central nervous system and the potential implications for therapeutic applications.
Article
Nutrition & Dietetics
Yali Ling, Feng Xu, Xuedi Xia, Dexing Dai, An Xiong, Ruoman Sun, Lei Qiu, Zhongjian Xie
Summary: The combination of vitamin D and calcium has a beneficial effect in preventing falls among elderly individuals, particularly those with 25(OH)D levels lower than 50 nmol/L. Vitamin D supplementation alone does not reduce the risk of falls in elderly individuals with 25(OH)D levels higher than 50 nmol/L.
CLINICAL NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Rong Zhou, Jiayu Li, Meiling Chen
Summary: This study used representative data from the China Health and Retirement Longitudinal Study (CHARLS) to examine the longitudinal association between cognitive impairment and subsequent falls in older adults. The results showed a significant association between cognitive impairment and falls, with different cognitive domains showing varying levels of association. These findings have implications for the identification and intervention of fall risk in specific high-risk groups.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Krystal M. Kirby, Sreekrishna Pillai, Robert M. Brouillette, Jeffrey N. Keller, Alyssa N. De Vito, John P. Bernstein, Arend W. A. Van Gemmert, Owen T. Carmichael
Summary: This study found that brain functioning, motor task, and cognitive task performance in challenging dual-task conditions all contribute to the risk of falling among older adults. Multiple factors are involved in determining fall characteristics.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Hebatallah M. Hussein, Mohammed F. Elyamany, Laila A. Rashed, Nada A. Sallam
Summary: The study shows that vitamin D plays a significant role in improving gut dysbiosis and gut barrier dysfunction induced by high-fat, high-sucrose diet/streptozotocin, and it can also suppress metabolic disorders and cognitive dysfunction associated with diabetes. Vitamin D reduces inflammation levels by regulating colonic CB1R and increasing the expression of tight junction proteins ZO-1 and occludin, leading to improved glycemic control and cognitive function.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Cell Biology
Sieglinde Zelzer, Edith Hofer, Andreas Meinitzer, Eva Fritz-Petrin, Sebastian Simstich, Walter Goessler, Reinhold Schmidt, Markus Herrmann
Summary: The study found that vitamin D metabolites were associated with memory function in elderly individuals, with deficient individuals showing poorer memory performance without structural brain atrophy. Future research should further investigate whether vitamin D supplementation can improve cognitive function.
Article
Geriatrics & Gerontology
Juan Luis Sanchez-Sanchez, Cristina Udina, Almudena Medina-Rincon, Mariano Esbri-Victor, Irene Bartolome-Martin, Debora Moral-Cuesta, Itxaso Marin-Epelde, Fernanda Ramon-Espinoza, Marina Sanchez-Latorre, Fernando Idoate, Adriana Goni-Sarries, Blanca Martinez-Martinez, Raquel Escudero Bonet, Julian Librero, Alvaro Casas-Herrero
Summary: This study aims to explore the effectiveness of an individualized exercise program and executive function-based cognitive training in preventing falls and fall-related outcomes in frail older adults. The study will recruit 320 older adults with a high risk of falling and compare the intervention group and control group in terms of falls incidence, physical and cognitive function, quality of life, etc.
Article
Endocrinology & Metabolism
Bess Dawson-Hughes, Jifan Wang, Kathryn Barger, Heike A. Bischoff-Ferrari, Christopher T. Sempos, Ramon A. Durazo-Arvizu, Lisa Ceglia
Summary: Supplementation with vitamin D may affect the risk of falling in older adults, and maintaining a 25(OH)D level between 20 and 40 ng/mL can help reduce the risk of falls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Jian Xiong, Wen-Xiong Xue
Summary: BackgroundPhysical frailty and cognitive aging have important influences on poor clinical outcomes in older adults. This study investigated the mediating role of vitamin D in the association between frailty and cognitive function. The results showed that vitamin D mediated the relationship between physical frailty and cognitive function, suggesting that vitamin D may play a role in linking frailty and cognitive decline.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Anna Y. Belorusova, Daniela Rovito, Yassmine Chebaro, Stefanie Doms, Lieve Verlinden, Annemieke Verstuyf, Daniel Metzger, Natacha Rochel, Gilles Laverny
Summary: This study demonstrates that BXL-62 and Gemini-72, two C-20-modified vitamin D analogs, restore the transcriptional activities of VDR variants unresponsive to the natural ligand. The elucidated mechanisms of action highlight the mutual adaptation between the ligand and the VDR ligand-binding pocket.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Beatrice Arosio, Paolo Dionigi Rossi, Evelyn Ferri, Matteo Cesari, Giovanni Vitale
Summary: Vitamin D levels are significantly associated with cognitive decline, with the lowest levels seen in dementia patients and higher levels in mild cognitive impairment patients.
Article
Nutrition & Dietetics
Noah C. Peeri, Kathleen M. Egan, Weiwen Chai, Meng-Hua Tao
Summary: Reduced cognitive function associated with aging has gained increasing attention as the US population ages. Magnesium plays a critical role in vitamin D biosynthesis and metabolism, and deficiencies in magnesium and vitamin D are associated with poor cognition. This study aimed to evaluate the associations of magnesium intake and serum 25-hydroxyvitamin D (25(OH)D) concentrations with cognition in older adults, finding that high magnesium intake may improve cognitive function, especially among those with sufficient vitamin D status. Further studies are needed to confirm these findings.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Psychology, Clinical
Brenna A. Cholerton, Kathleen L. Poston, Laurice Yang, Liana S. Rosenthal, Ted M. Dawson, Alexander Pantelyat, Karen L. Edwards, Lu Tian, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Shu-Ching Hu, Thomas J. Montine, Cyrus P. Zabetian
Summary: The study found that patients diagnosed with PD show significant decline in processing speed and semantic verbal fluency, even without evident cognitive impairment or dementia. This suggests that specific cognitive domains may experience subtle decline in PD patients, emphasizing the importance of early awareness of potential cognitive impacts in PD even in the absence of mild cognitive impairment or dementia.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2021)
Article
Medicine, Research & Experimental
Valerie C. Anderson, Ian J. Tagge, Aaron Doud, Xin Li, Charles S. Springer, Joseph F. Quinn, Jeffrey A. Kaye, Katherine Wild, William D. Rooney
Summary: Metabolic deficits at brain-fluid barriers, including reduced water efflux rate constant at the blood-cerebrospinal fluid barrier, are associated with cognitive decline in older adults. Significant associations were observed between water efflux rate constant and cognitive dysfunction, indicating a potential biomarker for cognitive impairment in later life.
Article
Immunology
Christopher Clark, Jonas Richiardi, Benedicte Marechal, Gene L. Bowman, Loic Dayon, Julius Popp
Summary: This study aimed to investigate the relationship between neuropsychiatric symptoms and inflammation. The results showed that neuroinflammation is involved in the pathophysiology of neuropsychiatric symptoms in older people, and it may explain the link between symptoms and more rapid clinical disease progression.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Magdalena Mroczek, Christopher Clark, Loic Dayon, Gene L. Bowman, Julius Popp
Summary: This study identified cerebrospinal fluid proteome alterations associated with neuropsychiatric symptoms (NPS). These alterations are related to the pathophysiology of Alzheimer's disease (AD) and cognitive decline, and may represent independent processes from AD. Furthermore, some of these protein changes were found to be associated with accelerated cognitive decline.
Article
Biochemistry & Molecular Biology
Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus P. Zabetian, Elaine R. Peskind, Ge Li, Daniel E. L. Promislow, Marie Y. Davis, Alexander Franks
Summary: Metabolomics has been utilized to analyze human cerebrospinal fluid samples and found strong separation between PD and AD patients and healthy controls in the metabolome. Key metabolites associated with PD and AD classification were identified, along with metabolic pathways linked to these neurodegenerative diseases.
Article
Public, Environmental & Occupational Health
Ana R. Quinones, Siting Chen, Corey L. Nagel, Anda Botoseneanu, Heather G. Allore, Jason T. Newsom, Stephen Thielke, Jeffrey Kaye
Summary: Evaluating the associations between multimorbidity combinations, racial/ethnic background, educational attainment, and sex with age-related cognitive changes is crucial. The study found racial/ethnic differences in cognitive trajectories in later life, with significant interactions with sex and education.
SSM-POPULATION HEALTH
(2022)
Article
Psychology, Clinical
Mira Leese, Nora Mattek, John P. K. Bernstein, Katherine E. Dorociak, Sarah Gothard, Jeffrey Kaye, Adriana M. Hughes
Summary: This study aimed to develop a brief web-based cognitive assessment tool and establish preliminary norms. The results showed that age was the only demographic variable associated with performance on the assessment tool, with older adults having slower completion time. Male participants generally had longer completion time compared to females. Overall, the tool was well-accepted by participants, with more than half willing to complete it on a weekly basis.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Delaram Safarpour, Barbara H. Brumbach, Monica Arena, Joseph Quinn, Sarah Diamond, Jay G. Nutt, RonaldF. Pfeiffer
Summary: This study aimed to investigate whether altered segmental gastrointestinal transit time (GITT) correlates with clinical response and plasma levodopa concentration (PLC) variability in patients with Parkinson's disease. The results showed no significant difference in GITT between typical and erratic responders. Additionally, Small Intestinal Bacterial Overgrowth (SIBO) was positive in half of the erratic responders and negative in most typical responders.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Jack C. Lennon, Nathan Hantke, Nora Mattek, Chao-Yi Wu, Hiroko Dodge, Rachel Wall, Zachary Beattie, Jeffrey Kaye, Lisa C. Silbert
Summary: A study found that older Veterans and their cohabitants reported significantly higher levels of blue mood and loneliness during the COVID-19 pandemic, as well as a significant decrease in travel away from home. The prevalence of these negative moods was not affected by the rural or urban residence.
CLINICAL GERONTOLOGIST
(2023)
Review
Clinical Neurology
Hussein N. Yassine, Wade Self, Bilal E. Kerman, Giulia Santoni, NandaKumar Navalpur Shanmugam, Laila Abdullah, Lesley R. Golden, Alfred N. Fonteh, Michael G. Harrington, Johannes Graff, Gary E. Gibson, Raj Kalaria, Jose A. Luchsinger, Howard H. Feldman, Russell H. Swerdlow, Lance A. Johnson, Benedict C. Albensi, Berislav Zlokovic, Rudolph Tanzi, Stephen Cunnane, Cecilia Samieri, Nikolaos Scarmeas, Gene L. Bowman
Summary: Disturbances in brain energy supply increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways may have therapeutic potential for Alzheimer's disease prevention and management. This review explores how nutrition and metabolism can regulate brain bioenergetics and mitigate AD risk, presenting novel therapeutic nutrition approaches integrating gut microbiome studies and neuroimaging.
ALZHEIMERS & DEMENTIA
(2023)
Article
Health Care Sciences & Services
Chao-Yi Wu, Deanne Tibbitts, Zachary Beattie, Hiroko Dodge, Jackilen Shannon, Jeffrey Kaye, Kerri Winters-Stone
Summary: This study found significant differences in health and behavior changes before and after a cancer diagnosis through continuous passive monitoring of older adults. Over the year preceding a cancer diagnosis, there were gradual reductions in step counts and weight, and gradual increases in pain severity, step count variability, hospitalization or emergency room visits, and days away from home overnight. In the year after the cancer diagnosis, there was a gradual increase in the number of pillbox door openings. The results of this study suggest that continuous passive monitoring can provide important information for health management.
JMIR FORMATIVE RESEARCH
(2023)
Article
Geriatrics & Gerontology
Hussein N. Yassine, Cecilia Samieri, Gill Livingston, Kimberly Glass, Maude Wagner, Christy Tangney, Brenda L. Plassman, M. Arfan Ikram, Robin M. Voigt, Yian Gu, Sid O'Bryant, Anne Marie Minihane, Suzanne Craft, Howard A. Fink, Suzanne Judd, Sandrine Andrieu, Gene L. Bowman, Edo Richard, Benedict Albensi, Emily Meyers, Serly Khosravian, Michele Solis, Maria Carrillo, Heather Snyder, Francine Grodstein, Nikolaos Scarmeas, Lon S. Schneider
Summary: Observational studies suggest potential cognitive benefits of nutritional factors, but systematic reviews of randomised trials show null effects. This article presents limitations in existing nutrition clinical trials for dementia prevention and provides recommendations for future trial developments.
LANCET HEALTHY LONGEVITY
(2022)
Article
Geriatrics & Gerontology
M. Maltais, P. de Souto Barreto, G. L. Bowman, A. D. Smith, C. Cantet, S. Andrieu, Y. Rolland
Summary: This study found that plasma homocysteine (Hcy) levels may modify the association between red blood cell n-3 PUFA and executive function. Individuals with high Hcy levels may benefit less from n-3 PUFA supplementation to prevent cognitive decline.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Psychology, Developmental
John P. K. Bernstein, Katherine Dorociak, Nora Mattek, Mira Leese, Chelsea Trapp, Zachary Beattie, Jeffrey Kaye, Adriana Hughes
Summary: Assessing everyday activities at home over a period of months to years can help predict cognitive decline in older adults. This study found that even a relatively brief monitoring period of 3 months can provide valuable diagnostic information related to computer use, sleep, medication use, pain, and independence, which are linked to cognitive function.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)